Catechol-O-methyltransferase-catalyzed rapid O-methylation of mutagenic flavonoids: metabolic inactivation as a possible reason for their lack of carcinogenicity in vivo

Quercetin is highly mutagenic in vitro, yet is not carcinogenic when administered chronically at large doses to rodents for 12 months. We hypothesized that catechol-O-methyltransferase-catalyzed O-methylation of quercetin and other mutagenic catechol-containing flavonoids may provide an efficient in...

Ausführliche Beschreibung