Intratracheal administration of mitochondrial DNA directly provokes lung inflammation through the TLR9–p38 MAPK pathway

An increasing number of studies have focused on the phenomenon that mitochondrial DNA (mtDNA) activates innate immunity responses. However, the specific role of mtDNA in inflammatory lung disease remains elusive. This study was designed to examine the proinflammatory effects of mtDNA in lungs and to...

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Veröffentlicht in:	Free radical biology & medicine 2015-06, Vol.83, p.149-158
Hauptverfasser:	Gu, Xiaoling, Wu, Guannan, Yao, Yanwen, Zeng, Junli, Shi, Donghong, Lv, Tangfeng, Luo, Liang, Song, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cytokines DNA, Mitochondrial - administration & dosage DNA, Mitochondrial - metabolism Drug Administration Routes Enzyme-Linked Immunosorbent Assay Fluorescent Antibody Technique Free radicals Inflammation Lung Macrophages - metabolism Macrophages - pathology Male Mice Mice, Inbred C57BL Mitochondrial DNA p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Pneumonia - genetics Pneumonia - metabolism Pneumonia - pathology Signal Transduction TLR9–p38 MAPK signal transduction pathway Toll-Like Receptor 9 - metabolism Trachea
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