Reinterpreting the best biomarker of oxidative stress: The 8-iso-PGF(2α)/PGF(2α) ratio distinguishes chemical from enzymatic lipid peroxidation

The biomarker 8-iso-prostaglandin F2α (8-iso-PGF2α) is regarded as the gold standard for detection of excessive chemical lipid peroxidation in humans. However, biosynthesis of 8-iso-PGF2α via enzymatic lipid peroxidation by prostaglandin-endoperoxide synthases (PGHSs), which are significantly induce...

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Veröffentlicht in:	Free radical biology & medicine 2015-06, Vol.83, p.245-251
Hauptverfasser:	van 't Erve, Thomas J, Lih, Fred B, Kadiiska, Maria B, Deterding, Leesa J, Eling, Thomas E, Mason, Ronald P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Biomarkers - metabolism Chromatography, Liquid Dinoprost - analogs & derivatives Dinoprost - metabolism Enzyme Inhibitors - pharmacology Humans Inflammation - diagnosis Inflammation - metabolism Lipid Peroxidation Male Oxidative Stress Prostaglandin-Endoperoxide Synthases - chemistry Prostaglandin-Endoperoxide Synthases - metabolism Rats Rats, Inbred F344 Tandem Mass Spectrometry
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