Knockout of the ergothioneine transporter ETT in zebrafish results in increased 8-oxoguanine levels

Ergothioneine (ET) is a natural compound that humans and other vertebrates must absorb from dietary sources. In general, ET is considered an intracellular antioxidant. However, the precise physiological purpose of ET and the consequences of ET deficiency are still unclear. The ergothioneine transpor...

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Veröffentlicht in:	Free radical biology & medicine 2015-06, Vol.83, p.178-185
Hauptverfasser:	Pfeiffer, Carolin, Bach, Markus, Bauer, Tim, Campos da Ponte, Julia, Schömig, Edgar, Gründemann, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Oxoguanine Animals Animals, Genetically Modified - genetics Animals, Genetically Modified - growth & development Animals, Genetically Modified - metabolism Antioxidants - metabolism Chromatography, Liquid Ergothioneine Ergothioneine - metabolism Ergothioneine transporter Guanine - analogs & derivatives Guanine - metabolism Mass Spectrometry Membrane Transport Proteins - deficiency Membrane Transport Proteins - genetics Oxidative Stress - drug effects Singlet oxygen Small Molecule Libraries Zebrafish - genetics Zebrafish - growth & development Zebrafish - metabolism Zebrafish knockout Zebrafish Proteins - deficiency Zebrafish Proteins - genetics
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