Dimethylarginine Dimethylaminohydrolase 2 Regulates Nitric Oxide Synthesis and Hemodynamics and Determines Outcome in Polymicrobial Sepsis

OBJECTIVE—Nitric oxide is a key to numerous physiological and pathophysiological processes. Nitric oxide production is regulated endogenously by 2 methylarginines, asymmetric dimethylarginine (ADMA) and monomethyl-L-arginine. The enzyme that specifically metabolizes asymmetric dimethylarginine and m...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2015-06, Vol.35 (6), p.1382-1392
Hauptverfasser:	Lambden, Simon, Kelly, Peter, Ahmetaj-Shala, Blerina, Wang, Zhen, Lee, Benjamin, Nandi, Manasi, Torondel, Belen, Delahaye, Matthew, Dowsett, Laura, Piper, Sophie, Tomlinson, James, Caplin, Ben, Colman, Lucy, Boruc, Olga, Slaviero, Anna, Zhao, Lan, Oliver, Eduardo, Khadayate, Sanjay, Singer, Mervyn, Arrigoni, Francesca, Leiper, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - metabolism Animals Bacterial Load Blood Pressure Disease Models, Animal Hemodynamics Macrophages, Peritoneal - metabolism Mice, Knockout Nitric Oxide - biosynthesis Prognosis Sepsis - metabolism Sepsis - microbiology Sepsis - physiopathology Sequence Analysis, RNA Telemetry
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