Metal Ion Coordination Essential for Specific Molecular Interactions of Butea monosperma Lectin: ITC and MD Simulation Studies

Crystal structure of Butea monosperma seed lectin (BML) was analyzed and the metal ion geometry identified. In order to understand the role of metal ions for the structural stability and ligand binding, studies of demetallized protein were carried out. Binding of different ligands like GalNAc, lacto...

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Veröffentlicht in:	Applied biochemistry and biotechnology 2015-05, Vol.176 (1), p.277-286
Hauptverfasser:	Abhilash, J, Haridas, M
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-amylase Amylases Binding Biochemistry Biotechnology Butea - chemistry Butea monosperma Calorimetry Chemistry Chemistry and Materials Science Crystal structure Crystallography, X-Ray Demetallization fungi Galactose Ions Lactose lectins Ligands Metal ions Metalloproteins - chemistry Metals Metals - chemistry Molecular biology Molecular dynamics Molecular interactions Molecular structure Plant Lectins - chemistry Protein Stability Protein structure Proteins Secondary structure Seeds - chemistry Simulation Structural stability Titration Titration calorimetry α-Amylase
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