Long-Term Persistence of Sterile Immunity in a Volunteer Immunized with X-Irradiated Plasmodium falciparum Sporozoites
Three volunteers were immunized by repeated exposure to the bites of Plasmodium falciparum- infected, X-irradiated mosquitoes to characterize immunologic responses and duration of protective immunity. A primary series of immunizations had been shown previously to induce sterile immunity in these vol...
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| Veröffentlicht in: | The Journal of infectious diseases 1993-10, Vol.168 (4), p.1066-1070 |
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| container_title | The Journal of infectious diseases |
| container_volume | 168 |
| creator | Edelman, Robert Hoffman, Stephen L. Davis, Jonathan R. Beier, Magda Sztein, Marcelo B. Losonsky, Genevieve Herrington, Deirdre A. Eddy, Hubert A. Hollingdale, Michael R. Gordon, Daniel M. Clyde, David F. |
| description | Three volunteers were immunized by repeated exposure to the bites of Plasmodium falciparum- infected, X-irradiated mosquitoes to characterize immunologic responses and duration of protective immunity. A primary series of immunizations had been shown previously to induce sterile immunity in these volunteers against sporozoite-induced P. falciparum malaria. In the current study, antibodies to sporozoites circulated at high levels for at least 9–12 months after the volunteers were administered booster bites from X-irradiated infective mosquitoes. One volunteer challenged a second time with P. falciparum 9 months after his last immunization was again shown to be protected, whereas all 5 control subjects developed patent infections. These results set a new standard for persistence of sterile immunity against experimental P. falciparum infection. |
| doi_str_mv | 10.1093/infdis/168.4.1066 |
| format | Article |
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A primary series of immunizations had been shown previously to induce sterile immunity in these volunteers against sporozoite-induced P. falciparum malaria. In the current study, antibodies to sporozoites circulated at high levels for at least 9–12 months after the volunteers were administered booster bites from X-irradiated infective mosquitoes. One volunteer challenged a second time with P. falciparum 9 months after his last immunization was again shown to be protected, whereas all 5 control subjects developed patent infections. 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A primary series of immunizations had been shown previously to induce sterile immunity in these volunteers against sporozoite-induced P. falciparum malaria. In the current study, antibodies to sporozoites circulated at high levels for at least 9–12 months after the volunteers were administered booster bites from X-irradiated infective mosquitoes. One volunteer challenged a second time with P. falciparum 9 months after his last immunization was again shown to be protected, whereas all 5 control subjects developed patent infections. These results set a new standard for persistence of sterile immunity against experimental P. falciparum infection.</description><subject>Adult</subject><subject>Animals</subject><subject>Anopheles</subject><subject>Antibodies</subject><subject>Antibodies, Protozoan - blood</subject><subject>Biological and medical sciences</subject><subject>Bites and Stings</subject><subject>Blood</subject><subject>Concise Communications</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunization</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria, Falciparum - immunology</subject><subject>Malaria, Falciparum - prevention & control</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parasitic diseases</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - immunology</subject><subject>Plasmodium falciparum - radiation effects</subject><subject>Protozoal diseases</subject><subject>Protozoan Vaccines - immunology</subject><subject>Sporozoites</subject><subject>Time Factors</subject><subject>Vaccination</subject><subject>Vaccines, Attenuated - immunology</subject><subject>Volunteerism</subject><subject>X-Rays</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkVFvFCEUhUmjqWvtD_DBhAfj27QwzALzaKprN9lok22bpi-EhYtSZ4YtMGr762Wz4_oEOd-5J5cDQm8pOaOkZed-cNanc8rlWVMUzo_QjM6ZqDin7AWaEVLXFZVt-wq9TumBENIwLo7RsWSCy5rN0K9VGL5X1xB7fAUx-ZRhMICDw-sM0XeAl30_Dj4_YT9gjW9DNw4ZIE76M1j82-cf-K5axqit17koV51OfbB-7LHTnfFbHct1vQ0xPAefIb1BLwtIcDqdJ-hm8fn64rJaffuyvPi4qkxDea4s564tT5m7snpLNxtT01ZQt2FOmoZYCvNWgyXQSG4BhBCMU2ulKZohkrIT9GGfu43hcYSUVe-Tga7TA4QxqdJcLajkxUj3RhNDShGc2kbf6_ikKFG7rtW-692EatSu6zLzbgofNz3Yw8RUbuHvJ66T0Z2LejAl4Z-tIU0tWvE_5iHlEA-YEUpZzWXh1Z7vPufPgev4U3HBxFxd3t2r9WLxlZHbtfrE_gKkV6OG</recordid><startdate>19931001</startdate><enddate>19931001</enddate><creator>Edelman, Robert</creator><creator>Hoffman, Stephen L.</creator><creator>Davis, Jonathan R.</creator><creator>Beier, Magda</creator><creator>Sztein, Marcelo B.</creator><creator>Losonsky, Genevieve</creator><creator>Herrington, Deirdre A.</creator><creator>Eddy, Hubert A.</creator><creator>Hollingdale, Michael R.</creator><creator>Gordon, Daniel M.</creator><creator>Clyde, David F.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope></search><sort><creationdate>19931001</creationdate><title>Long-Term Persistence of Sterile Immunity in a Volunteer Immunized with X-Irradiated Plasmodium falciparum Sporozoites</title><author>Edelman, Robert ; Hoffman, Stephen L. ; Davis, Jonathan R. ; Beier, Magda ; Sztein, Marcelo B. ; Losonsky, Genevieve ; Herrington, Deirdre A. ; Eddy, Hubert A. ; Hollingdale, Michael R. ; Gordon, Daniel M. ; Clyde, David F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-d66f96135f00091bbc21971fb3f8c40d1e59aed0e486dee777361dd8ced0c0813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Anopheles</topic><topic>Antibodies</topic><topic>Antibodies, Protozoan - blood</topic><topic>Biological and medical sciences</topic><topic>Bites and Stings</topic><topic>Blood</topic><topic>Concise Communications</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Immunity</topic><topic>Immunization</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Malaria, Falciparum - immunology</topic><topic>Malaria, Falciparum - prevention & control</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parasitic diseases</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - immunology</topic><topic>Plasmodium falciparum - radiation effects</topic><topic>Protozoal diseases</topic><topic>Protozoan Vaccines - immunology</topic><topic>Sporozoites</topic><topic>Time Factors</topic><topic>Vaccination</topic><topic>Vaccines, Attenuated - immunology</topic><topic>Volunteerism</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Edelman, Robert</creatorcontrib><creatorcontrib>Hoffman, Stephen L.</creatorcontrib><creatorcontrib>Davis, Jonathan R.</creatorcontrib><creatorcontrib>Beier, Magda</creatorcontrib><creatorcontrib>Sztein, Marcelo B.</creatorcontrib><creatorcontrib>Losonsky, Genevieve</creatorcontrib><creatorcontrib>Herrington, Deirdre A.</creatorcontrib><creatorcontrib>Eddy, Hubert A.</creatorcontrib><creatorcontrib>Hollingdale, Michael R.</creatorcontrib><creatorcontrib>Gordon, Daniel M.</creatorcontrib><creatorcontrib>Clyde, David F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Edelman, Robert</au><au>Hoffman, Stephen L.</au><au>Davis, Jonathan R.</au><au>Beier, Magda</au><au>Sztein, Marcelo B.</au><au>Losonsky, Genevieve</au><au>Herrington, Deirdre A.</au><au>Eddy, Hubert A.</au><au>Hollingdale, Michael R.</au><au>Gordon, Daniel M.</au><au>Clyde, David F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term Persistence of Sterile Immunity in a Volunteer Immunized with X-Irradiated Plasmodium falciparum Sporozoites</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1993-10-01</date><risdate>1993</risdate><volume>168</volume><issue>4</issue><spage>1066</spage><epage>1070</epage><pages>1066-1070</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Three volunteers were immunized by repeated exposure to the bites of Plasmodium falciparum- infected, X-irradiated mosquitoes to characterize immunologic responses and duration of protective immunity. A primary series of immunizations had been shown previously to induce sterile immunity in these volunteers against sporozoite-induced P. falciparum malaria. In the current study, antibodies to sporozoites circulated at high levels for at least 9–12 months after the volunteers were administered booster bites from X-irradiated infective mosquitoes. One volunteer challenged a second time with P. falciparum 9 months after his last immunization was again shown to be protected, whereas all 5 control subjects developed patent infections. These results set a new standard for persistence of sterile immunity against experimental P. falciparum infection.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>8376823</pmid><doi>10.1093/infdis/168.4.1066</doi><tpages>5</tpages></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adult Animals Anopheles Antibodies Antibodies, Protozoan - blood Biological and medical sciences Bites and Stings Blood Concise Communications Enzyme-Linked Immunosorbent Assay Human protozoal diseases Humans Immunity Immunization Infections Infectious diseases Malaria Malaria, Falciparum - immunology Malaria, Falciparum - prevention & control Male Medical sciences Parasitic diseases Plasmodium falciparum Plasmodium falciparum - immunology Plasmodium falciparum - radiation effects Protozoal diseases Protozoan Vaccines - immunology Sporozoites Time Factors Vaccination Vaccines, Attenuated - immunology Volunteerism X-Rays |
| title | Long-Term Persistence of Sterile Immunity in a Volunteer Immunized with X-Irradiated Plasmodium falciparum Sporozoites |
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