Influence of antioxidants on cadmium toxicity of mouse preimplantation embryos in vitro

To test the hypothesis that the developmental toxicity of cadmium (Cd) is due in part to oxidative damage, embryos were cultured in medium containing 0.0, 1.0, 3.0, or 6.0 μM Cd with or without various antioxidants for 72 h. Ascorbate, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) a...

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Veröffentlicht in:	Toxicology (Amsterdam) 1995-05, Vol.99 (1), p.11-18
Hauptverfasser:	Peters, Jeffrey M., Duncan, John R., Wiley, Lynn M., Keen, Carl L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Antioxidants Antioxidants - pharmacology Biological and medical sciences Blastocyst - drug effects Cadmium Cadmium - antagonists & inhibitors Cadmium - toxicity Development Embryo Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development - drug effects Fundamental and applied biological sciences. Psychology Glutathione Glutathione - pharmacology In Vitro Techniques Mice Mice, Inbred ICR Oxidative damage Teratology. Teratogens
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