Intrathymic transplantation of allogeneic perinatal islets does not induce donor-specific tolerance

Intrathymic transplantation of adult rat collagenase-isolated islets has been shown to induce tolerance to a subsequent allograft of donor islets to the renal subcapsular site. This suggests that donor-specific tolerance is induced by the presence of foreign antigens in the thymus and the thymus...

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Veröffentlicht in:	Transplantation 1995-03, Vol.59 (5), p.784-787
Hauptverfasser:	KETCHUM, R. J, MOYER, C, FUPING PAN, DONALDSON, D. L, FORSTER, J, MOORE, W. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antilymphocyte Serum - therapeutic use Biological and medical sciences Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - surgery Female Immune Tolerance - immunology Immunotherapy, Adoptive Islets of Langerhans Transplantation - immunology Male Medical sciences Rats Rats, Inbred F344 Rats, Inbred WF Spleen - cytology Streptozocin Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of endocrine glands Thymus Gland Transplantation, Heterotopic
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