Quality of life outcomes in women with endometriosis are highly influenced by recruitment strategies
STUDY QUESTION To what extent are outcome measures in endometriosis-related quality of life studies influenced by the setting in which patient recruitment is performed? SUMMARY ANSWER Quality of life outcomes in women with endometriosis are highly influenced by recruitment strategies. WHAT IS KNOWN...
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| Veröffentlicht in: | Human reproduction (Oxford) 2015-06, Vol.30 (6), p.1331-1341 |
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| creator | De Graaff, A.A. Dirksen, C.D. Simoens, S. De Bie, B. Hummelshoj, L. D'Hooghe, T.M. Dunselman, G.A.J. |
| description | STUDY QUESTION
To what extent are outcome measures in endometriosis-related quality of life studies influenced by the setting in which patient recruitment is performed?
SUMMARY ANSWER
Quality of life outcomes in women with endometriosis are highly influenced by recruitment strategies.
WHAT IS KNOWN ALREADY
Most studies on quality of life in women with endometriosis are conducted in tertiary care centres or patient associations. It is conceivable that the setting in which patient recruitment is performed influences the quality of life results. This has not been investigated before.
STUDY DESIGN, SIZE, DURATION
Retrospective questionnaire based cohort study (part of the World Endometriosis Research Foundation (WERF) EndoCost study). The investigated women were recruited in three settings: a tertiary care centre for endometriosis (n = 135); five secondary care centres (n = 63); an endometriosis patient association (n = 291).
PARTICIPANTS/MATERIALS, SETTING, METHODS
The secondary and tertiary care population included women with a laparoscopic and/or histological diagnosis of endometriosis. The patient association population consisted of women with a self-reported diagnosis of surgically confirmed endometriosis.
MAIN RESULTS AND THE ROLE OF CHANCE
The populations did not differ in terms of age, co-morbidities and education level. Delay of diagnosis was the longest in the patient association (median 7 years) (tertiary care 2 years; secondary care 1.5 years) (P < 0.001). The tertiary care population reported more laparotomies (64%) than the other populations (secondary care 43%; patient association 47%) (P = 0.002). Affected job was least prevalent in the secondary care setting (35%) (patient association 64%; tertiary care 56%) (P < 0.001). Affected relationships were most prevalent in the patient association setting (52%) (tertiary care 38%; secondary care 22%) (P < 0.001). Chronic pain was least prevalent in patients in secondary care (44%) (tertiary care 65%; patient association 61%) (P = 0.009). Substantial differences in quality of life were detected between secondary care (median physical component 50.4, mental component 49.6); tertiary care (physical component 46.2, mental component 46.2) and the patient association (physical component 45.0, mental component 44.6) (P < 0.001, P = 0.018).
LIMITATIONS, REASONS FOR CAUTION
The response rate was relatively low (35%). Analysis of the hospital populations revealed that non-responders and responders did not diffe |
| doi_str_mv | 10.1093/humrep/dev084 |
| format | Article |
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To what extent are outcome measures in endometriosis-related quality of life studies influenced by the setting in which patient recruitment is performed?
SUMMARY ANSWER
Quality of life outcomes in women with endometriosis are highly influenced by recruitment strategies.
WHAT IS KNOWN ALREADY
Most studies on quality of life in women with endometriosis are conducted in tertiary care centres or patient associations. It is conceivable that the setting in which patient recruitment is performed influences the quality of life results. This has not been investigated before.
STUDY DESIGN, SIZE, DURATION
Retrospective questionnaire based cohort study (part of the World Endometriosis Research Foundation (WERF) EndoCost study). The investigated women were recruited in three settings: a tertiary care centre for endometriosis (n = 135); five secondary care centres (n = 63); an endometriosis patient association (n = 291).
PARTICIPANTS/MATERIALS, SETTING, METHODS
The secondary and tertiary care population included women with a laparoscopic and/or histological diagnosis of endometriosis. The patient association population consisted of women with a self-reported diagnosis of surgically confirmed endometriosis.
MAIN RESULTS AND THE ROLE OF CHANCE
The populations did not differ in terms of age, co-morbidities and education level. Delay of diagnosis was the longest in the patient association (median 7 years) (tertiary care 2 years; secondary care 1.5 years) (P < 0.001). The tertiary care population reported more laparotomies (64%) than the other populations (secondary care 43%; patient association 47%) (P = 0.002). Affected job was least prevalent in the secondary care setting (35%) (patient association 64%; tertiary care 56%) (P < 0.001). Affected relationships were most prevalent in the patient association setting (52%) (tertiary care 38%; secondary care 22%) (P < 0.001). Chronic pain was least prevalent in patients in secondary care (44%) (tertiary care 65%; patient association 61%) (P = 0.009). Substantial differences in quality of life were detected between secondary care (median physical component 50.4, mental component 49.6); tertiary care (physical component 46.2, mental component 46.2) and the patient association (physical component 45.0, mental component 44.6) (P < 0.001, P = 0.018).
LIMITATIONS, REASONS FOR CAUTION
The response rate was relatively low (35%). Analysis of the hospital populations revealed that non-responders and responders did not differ with respect to age or revised American Fertility Society classification, indicating that the non-responder bias is limited. However, other factors, such as social and marital status or symptomatology, might be different for non-responders.
Missing values were analysed as if the symptom was not present. Missing values never exceeded 10%, except for one value. Therefore, it can be expected that the effect of missing data on the outcome is negligible. Twenty-five patients belonged to more than one category. A sensitivity analysis showed that the influence of assigning patients to another category was limited.
WIDER IMPLICATIONS OF THE FINDINGS
Outcomes regarding quality of life are highly influenced by recruitment strategy. None of the groups appeared to be a representative selection of the total population of women with endometriosis. An alternative strategy for creating a representative population for cost and quality of life studies is probably to recruit women who live in a specific geographic area rather than women that visit a specific hospital or are a member of a patient association.
STUDY FUNDING/COMPETING INTEREST(S)
The WERF EndoCost study was funded by the World Endometriosis Research Foundation. The sponsors did not have a role in the design and conduct of this study: collection, management, analysis, interpretation of the data; preparation, review, approval of the manuscript. L.H. is the chief executive and T.M.D. was a board member of WERF at the time of funding. T.M.D holds the Merck-Serono Chair and the Ferring Chair in Reproductive Medicine in Leuven, Belgium and has served as consultant for Merck-Serono, Schering-Plough, Astellas, and Arresto.
TRIAL REGISTRATION NUMBER
Not applicable.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/dev084</identifier><identifier>PMID: 25908657</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Endometriosis - psychology ; Female ; Humans ; Primary Health Care ; Quality of Life ; Retrospective Studies ; Secondary Care Centers ; Tertiary Care Centers</subject><ispartof>Human reproduction (Oxford), 2015-06, Vol.30 (6), p.1331-1341</ispartof><rights>The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2015</rights><rights>The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-da259f7e5535cf7a964001f628ebb6074820cf6bd50968092569dccf71a154403</citedby><cites>FETCH-LOGICAL-c365t-da259f7e5535cf7a964001f628ebb6074820cf6bd50968092569dccf71a154403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,1586,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25908657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Graaff, A.A.</creatorcontrib><creatorcontrib>Dirksen, C.D.</creatorcontrib><creatorcontrib>Simoens, S.</creatorcontrib><creatorcontrib>De Bie, B.</creatorcontrib><creatorcontrib>Hummelshoj, L.</creatorcontrib><creatorcontrib>D'Hooghe, T.M.</creatorcontrib><creatorcontrib>Dunselman, G.A.J.</creatorcontrib><title>Quality of life outcomes in women with endometriosis are highly influenced by recruitment strategies</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>STUDY QUESTION
To what extent are outcome measures in endometriosis-related quality of life studies influenced by the setting in which patient recruitment is performed?
SUMMARY ANSWER
Quality of life outcomes in women with endometriosis are highly influenced by recruitment strategies.
WHAT IS KNOWN ALREADY
Most studies on quality of life in women with endometriosis are conducted in tertiary care centres or patient associations. It is conceivable that the setting in which patient recruitment is performed influences the quality of life results. This has not been investigated before.
STUDY DESIGN, SIZE, DURATION
Retrospective questionnaire based cohort study (part of the World Endometriosis Research Foundation (WERF) EndoCost study). The investigated women were recruited in three settings: a tertiary care centre for endometriosis (n = 135); five secondary care centres (n = 63); an endometriosis patient association (n = 291).
PARTICIPANTS/MATERIALS, SETTING, METHODS
The secondary and tertiary care population included women with a laparoscopic and/or histological diagnosis of endometriosis. The patient association population consisted of women with a self-reported diagnosis of surgically confirmed endometriosis.
MAIN RESULTS AND THE ROLE OF CHANCE
The populations did not differ in terms of age, co-morbidities and education level. Delay of diagnosis was the longest in the patient association (median 7 years) (tertiary care 2 years; secondary care 1.5 years) (P < 0.001). The tertiary care population reported more laparotomies (64%) than the other populations (secondary care 43%; patient association 47%) (P = 0.002). Affected job was least prevalent in the secondary care setting (35%) (patient association 64%; tertiary care 56%) (P < 0.001). Affected relationships were most prevalent in the patient association setting (52%) (tertiary care 38%; secondary care 22%) (P < 0.001). Chronic pain was least prevalent in patients in secondary care (44%) (tertiary care 65%; patient association 61%) (P = 0.009). Substantial differences in quality of life were detected between secondary care (median physical component 50.4, mental component 49.6); tertiary care (physical component 46.2, mental component 46.2) and the patient association (physical component 45.0, mental component 44.6) (P < 0.001, P = 0.018).
LIMITATIONS, REASONS FOR CAUTION
The response rate was relatively low (35%). Analysis of the hospital populations revealed that non-responders and responders did not differ with respect to age or revised American Fertility Society classification, indicating that the non-responder bias is limited. However, other factors, such as social and marital status or symptomatology, might be different for non-responders.
Missing values were analysed as if the symptom was not present. Missing values never exceeded 10%, except for one value. Therefore, it can be expected that the effect of missing data on the outcome is negligible. Twenty-five patients belonged to more than one category. A sensitivity analysis showed that the influence of assigning patients to another category was limited.
WIDER IMPLICATIONS OF THE FINDINGS
Outcomes regarding quality of life are highly influenced by recruitment strategy. None of the groups appeared to be a representative selection of the total population of women with endometriosis. An alternative strategy for creating a representative population for cost and quality of life studies is probably to recruit women who live in a specific geographic area rather than women that visit a specific hospital or are a member of a patient association.
STUDY FUNDING/COMPETING INTEREST(S)
The WERF EndoCost study was funded by the World Endometriosis Research Foundation. The sponsors did not have a role in the design and conduct of this study: collection, management, analysis, interpretation of the data; preparation, review, approval of the manuscript. L.H. is the chief executive and T.M.D. was a board member of WERF at the time of funding. T.M.D holds the Merck-Serono Chair and the Ferring Chair in Reproductive Medicine in Leuven, Belgium and has served as consultant for Merck-Serono, Schering-Plough, Astellas, and Arresto.
TRIAL REGISTRATION NUMBER
Not applicable.</description><subject>Adult</subject><subject>Endometriosis - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Primary Health Care</subject><subject>Quality of Life</subject><subject>Retrospective Studies</subject><subject>Secondary Care Centers</subject><subject>Tertiary Care Centers</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMozji6dCtZuqmTtE3aLmXwBYIIui5pejONtM2Yh9J_b6SjLt3cB3z33MNB6JySK0qqbN2FwcJu3cIHKfMDtKQ5J0maMXKIliTlZUIppwt04twbIXEs-TFapKwiJWfFErXPQfTaT9go3GsF2AQvzQAO6xF_xiFW7TsMYxsXb7Vx2mFhAXd62_VTxFQfYJTQ4mbCFqQN2sczj523wsNWgztFR0r0Ds72fYVeb29eNvfJ49Pdw-b6MZEZZz5pRfSlCmAsY1IVouJ5tKx4WkLTcFLkZUqk4k3LSMVLUqWMV62MJBWU5TnJVuhy1t1Z8x7A-XrQTkLfixFMcDXlZZqnPGc0osmMSmucs6DqndWDsFNNSf0dbD0HW8_BRv5iLx2aAdpf-ifJv98m7P7R-gJcN4VU</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>De Graaff, A.A.</creator><creator>Dirksen, C.D.</creator><creator>Simoens, S.</creator><creator>De Bie, B.</creator><creator>Hummelshoj, L.</creator><creator>D'Hooghe, T.M.</creator><creator>Dunselman, G.A.J.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150601</creationdate><title>Quality of life outcomes in women with endometriosis are highly influenced by recruitment strategies</title><author>De Graaff, A.A. ; Dirksen, C.D. ; Simoens, S. ; De Bie, B. ; Hummelshoj, L. ; D'Hooghe, T.M. ; Dunselman, G.A.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-da259f7e5535cf7a964001f628ebb6074820cf6bd50968092569dccf71a154403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Endometriosis - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Primary Health Care</topic><topic>Quality of Life</topic><topic>Retrospective Studies</topic><topic>Secondary Care Centers</topic><topic>Tertiary Care Centers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Graaff, A.A.</creatorcontrib><creatorcontrib>Dirksen, C.D.</creatorcontrib><creatorcontrib>Simoens, S.</creatorcontrib><creatorcontrib>De Bie, B.</creatorcontrib><creatorcontrib>Hummelshoj, L.</creatorcontrib><creatorcontrib>D'Hooghe, T.M.</creatorcontrib><creatorcontrib>Dunselman, G.A.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Graaff, A.A.</au><au>Dirksen, C.D.</au><au>Simoens, S.</au><au>De Bie, B.</au><au>Hummelshoj, L.</au><au>D'Hooghe, T.M.</au><au>Dunselman, G.A.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality of life outcomes in women with endometriosis are highly influenced by recruitment strategies</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>30</volume><issue>6</issue><spage>1331</spage><epage>1341</epage><pages>1331-1341</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><abstract>STUDY QUESTION
To what extent are outcome measures in endometriosis-related quality of life studies influenced by the setting in which patient recruitment is performed?
SUMMARY ANSWER
Quality of life outcomes in women with endometriosis are highly influenced by recruitment strategies.
WHAT IS KNOWN ALREADY
Most studies on quality of life in women with endometriosis are conducted in tertiary care centres or patient associations. It is conceivable that the setting in which patient recruitment is performed influences the quality of life results. This has not been investigated before.
STUDY DESIGN, SIZE, DURATION
Retrospective questionnaire based cohort study (part of the World Endometriosis Research Foundation (WERF) EndoCost study). The investigated women were recruited in three settings: a tertiary care centre for endometriosis (n = 135); five secondary care centres (n = 63); an endometriosis patient association (n = 291).
PARTICIPANTS/MATERIALS, SETTING, METHODS
The secondary and tertiary care population included women with a laparoscopic and/or histological diagnosis of endometriosis. The patient association population consisted of women with a self-reported diagnosis of surgically confirmed endometriosis.
MAIN RESULTS AND THE ROLE OF CHANCE
The populations did not differ in terms of age, co-morbidities and education level. Delay of diagnosis was the longest in the patient association (median 7 years) (tertiary care 2 years; secondary care 1.5 years) (P < 0.001). The tertiary care population reported more laparotomies (64%) than the other populations (secondary care 43%; patient association 47%) (P = 0.002). Affected job was least prevalent in the secondary care setting (35%) (patient association 64%; tertiary care 56%) (P < 0.001). Affected relationships were most prevalent in the patient association setting (52%) (tertiary care 38%; secondary care 22%) (P < 0.001). Chronic pain was least prevalent in patients in secondary care (44%) (tertiary care 65%; patient association 61%) (P = 0.009). Substantial differences in quality of life were detected between secondary care (median physical component 50.4, mental component 49.6); tertiary care (physical component 46.2, mental component 46.2) and the patient association (physical component 45.0, mental component 44.6) (P < 0.001, P = 0.018).
LIMITATIONS, REASONS FOR CAUTION
The response rate was relatively low (35%). Analysis of the hospital populations revealed that non-responders and responders did not differ with respect to age or revised American Fertility Society classification, indicating that the non-responder bias is limited. However, other factors, such as social and marital status or symptomatology, might be different for non-responders.
Missing values were analysed as if the symptom was not present. Missing values never exceeded 10%, except for one value. Therefore, it can be expected that the effect of missing data on the outcome is negligible. Twenty-five patients belonged to more than one category. A sensitivity analysis showed that the influence of assigning patients to another category was limited.
WIDER IMPLICATIONS OF THE FINDINGS
Outcomes regarding quality of life are highly influenced by recruitment strategy. None of the groups appeared to be a representative selection of the total population of women with endometriosis. An alternative strategy for creating a representative population for cost and quality of life studies is probably to recruit women who live in a specific geographic area rather than women that visit a specific hospital or are a member of a patient association.
STUDY FUNDING/COMPETING INTEREST(S)
The WERF EndoCost study was funded by the World Endometriosis Research Foundation. The sponsors did not have a role in the design and conduct of this study: collection, management, analysis, interpretation of the data; preparation, review, approval of the manuscript. L.H. is the chief executive and T.M.D. was a board member of WERF at the time of funding. T.M.D holds the Merck-Serono Chair and the Ferring Chair in Reproductive Medicine in Leuven, Belgium and has served as consultant for Merck-Serono, Schering-Plough, Astellas, and Arresto.
TRIAL REGISTRATION NUMBER
Not applicable.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>25908657</pmid><doi>10.1093/humrep/dev084</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-1161 |
| ispartof | Human reproduction (Oxford), 2015-06, Vol.30 (6), p.1331-1341 |
| issn | 0268-1161 1460-2350 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1682426451 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Endometriosis - psychology Female Humans Primary Health Care Quality of Life Retrospective Studies Secondary Care Centers Tertiary Care Centers |
| title | Quality of life outcomes in women with endometriosis are highly influenced by recruitment strategies |
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