Serum cystatin C and microalbuminuria in burn patients with acute kidney injury
Background This study was aimed at evaluating the effectiveness of serum cystatin C and microalbuminuria as diagnostic markers for acute kidney injury (AKI) in major burn patients. Materials and methods Major burn adult patients admitted to the burn intensive care unit within 24 h from the onset of...
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| Veröffentlicht in: | European journal of clinical investigation 2015-06, Vol.45 (6), p.594-600 |
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| creator | Yim, Haejun Kym, Dohern Seo, Dong Kook Yoon, Jaechul Yang, Hyeong-Tae Lee, Jeonghwan Cho, Yong-Suk Hur, Jun Chun, Wook Han, Seong-Woo |
| description | Background
This study was aimed at evaluating the effectiveness of serum cystatin C and microalbuminuria as diagnostic markers for acute kidney injury (AKI) in major burn patients.
Materials and methods
Major burn adult patients admitted to the burn intensive care unit within 24 h from the onset of injury were enrolled. Serum cystatin C and microalbuminuria (albumin–creatinine ratio, ACR) were obtained at postburn days 1, 3, 7, 14, 21 and 28. The patients were divided into two groups of the AKI group and the nonacute kidney injury group.
Results
A total of 97 patients were enrolled in this study. Acute kidney injury was diagnosed in 40 patients (41·2%) at postburn day 17·3 ± 7·9. The area under the curve of the receiver operating characteristic curve for serum cystatin C was 0·808 (95% CI, 0·711–0·905, P |
| doi_str_mv | 10.1111/eci.12452 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1682424277</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1682424277</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3632-53e12f99b43366558e87029f8c86686ecddea638911219663e82cf9f4f9d0e353</originalsourceid><addsrcrecordid>eNp1kDlPxDAQhS0EguUo-APIJRQBH7Fjl2hZDgmBxCFKy-tMhCHJLnYsyL_HsEDHTDHFfO9J7yG0T8kxzXMCzh9TVgq2hiaUS1EwLtk6mhBCy4Lpim2h7RhfCCGKcraJtphQmnGhJuj2HkLqsBvjYAff4ym2fY0778LCtvPU-T4Fb3H-zFPo8TJD0A8Rv_vhGVuXBsCvvu5hzMhLCuMu2mhsG2Hv5-6gx_PZw_SyuL69uJqeXheOS84KwYGyRut5ybmUQihQFWG6UU5JqSS4ugYrudKUMqql5KCYa3RTNromwAXfQYcr32VYvCWIg-l8dNC2todFioZKxcq8VZXRoxWaM8UYoDHL4DsbRkOJ-erP5P7Md3-ZPfixTfMO6j_yt7AMnKyAd9_C-L-TmU2vfi2LlcLHAT7-FDa8GlnxSpinmwtTnuX8d7wy5_wTa7WHhw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1682424277</pqid></control><display><type>article</type><title>Serum cystatin C and microalbuminuria in burn patients with acute kidney injury</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Yim, Haejun ; Kym, Dohern ; Seo, Dong Kook ; Yoon, Jaechul ; Yang, Hyeong-Tae ; Lee, Jeonghwan ; Cho, Yong-Suk ; Hur, Jun ; Chun, Wook ; Han, Seong-Woo</creator><creatorcontrib>Yim, Haejun ; Kym, Dohern ; Seo, Dong Kook ; Yoon, Jaechul ; Yang, Hyeong-Tae ; Lee, Jeonghwan ; Cho, Yong-Suk ; Hur, Jun ; Chun, Wook ; Han, Seong-Woo</creatorcontrib><description>Background
This study was aimed at evaluating the effectiveness of serum cystatin C and microalbuminuria as diagnostic markers for acute kidney injury (AKI) in major burn patients.
Materials and methods
Major burn adult patients admitted to the burn intensive care unit within 24 h from the onset of injury were enrolled. Serum cystatin C and microalbuminuria (albumin–creatinine ratio, ACR) were obtained at postburn days 1, 3, 7, 14, 21 and 28. The patients were divided into two groups of the AKI group and the nonacute kidney injury group.
Results
A total of 97 patients were enrolled in this study. Acute kidney injury was diagnosed in 40 patients (41·2%) at postburn day 17·3 ± 7·9. The area under the curve of the receiver operating characteristic curve for serum cystatin C was 0·808 (95% CI, 0·711–0·905, P < 0·001) at postburn day 7 and 0·908 (95% CI, 0·843–0·973, P < 0·001) at postburn day 14. The results were 0·610 (95% CI, 0·497–0·724, P = 0·069) for ACR at postburn day 7 and 0·694 (95% CI, 0·589–0·798, P = 0·001) at postburn day 14. The optimal cut‐off value of serum cystatin C at postburn day 14 and ACR at postburn day 14 were 0·85 mg/L (sensitivity, 89·5%; specificity, 82·5%) and 41·51 mg/g cre (sensitivity, 60·5%; specificity, 61·4%), respectively. Serum cystatin C at postburn day 14 was the only significant factor in relation to AKI.
Conclusions
Serum cystatin C is a valuable diagnostic marker, whereas microalbuminuria is a relatively less significant marker for AKI in major burn patients.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1111/eci.12452</identifier><identifier>PMID: 25892358</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Acute kidney injury ; Acute Kidney Injury - diagnosis ; Acute Kidney Injury - etiology ; Albuminuria - blood ; Albuminuria - etiology ; Biomarkers - metabolism ; Burns - blood ; Burns - complications ; Burns - urine ; Creatinine - metabolism ; cystatin C ; Cystatin C - metabolism ; Early Diagnosis ; Female ; Humans ; major burn ; Male ; microalbuminuria ; Middle Aged ; Prospective Studies ; Statistics as Topic</subject><ispartof>European journal of clinical investigation, 2015-06, Vol.45 (6), p.594-600</ispartof><rights>2015 Stichting European Society for Clinical Investigation Journal Foundation</rights><rights>2015 Stichting European Society for Clinical Investigation Journal Foundation.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3632-53e12f99b43366558e87029f8c86686ecddea638911219663e82cf9f4f9d0e353</citedby><cites>FETCH-LOGICAL-c3632-53e12f99b43366558e87029f8c86686ecddea638911219663e82cf9f4f9d0e353</cites><orcidid>0000-0001-9178-0599</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Feci.12452$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Feci.12452$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25892358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yim, Haejun</creatorcontrib><creatorcontrib>Kym, Dohern</creatorcontrib><creatorcontrib>Seo, Dong Kook</creatorcontrib><creatorcontrib>Yoon, Jaechul</creatorcontrib><creatorcontrib>Yang, Hyeong-Tae</creatorcontrib><creatorcontrib>Lee, Jeonghwan</creatorcontrib><creatorcontrib>Cho, Yong-Suk</creatorcontrib><creatorcontrib>Hur, Jun</creatorcontrib><creatorcontrib>Chun, Wook</creatorcontrib><creatorcontrib>Han, Seong-Woo</creatorcontrib><title>Serum cystatin C and microalbuminuria in burn patients with acute kidney injury</title><title>European journal of clinical investigation</title><addtitle>Eur J Clin Invest</addtitle><description>Background
This study was aimed at evaluating the effectiveness of serum cystatin C and microalbuminuria as diagnostic markers for acute kidney injury (AKI) in major burn patients.
Materials and methods
Major burn adult patients admitted to the burn intensive care unit within 24 h from the onset of injury were enrolled. Serum cystatin C and microalbuminuria (albumin–creatinine ratio, ACR) were obtained at postburn days 1, 3, 7, 14, 21 and 28. The patients were divided into two groups of the AKI group and the nonacute kidney injury group.
Results
A total of 97 patients were enrolled in this study. Acute kidney injury was diagnosed in 40 patients (41·2%) at postburn day 17·3 ± 7·9. The area under the curve of the receiver operating characteristic curve for serum cystatin C was 0·808 (95% CI, 0·711–0·905, P < 0·001) at postburn day 7 and 0·908 (95% CI, 0·843–0·973, P < 0·001) at postburn day 14. The results were 0·610 (95% CI, 0·497–0·724, P = 0·069) for ACR at postburn day 7 and 0·694 (95% CI, 0·589–0·798, P = 0·001) at postburn day 14. The optimal cut‐off value of serum cystatin C at postburn day 14 and ACR at postburn day 14 were 0·85 mg/L (sensitivity, 89·5%; specificity, 82·5%) and 41·51 mg/g cre (sensitivity, 60·5%; specificity, 61·4%), respectively. Serum cystatin C at postburn day 14 was the only significant factor in relation to AKI.
Conclusions
Serum cystatin C is a valuable diagnostic marker, whereas microalbuminuria is a relatively less significant marker for AKI in major burn patients.</description><subject>Acute kidney injury</subject><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - etiology</subject><subject>Albuminuria - blood</subject><subject>Albuminuria - etiology</subject><subject>Biomarkers - metabolism</subject><subject>Burns - blood</subject><subject>Burns - complications</subject><subject>Burns - urine</subject><subject>Creatinine - metabolism</subject><subject>cystatin C</subject><subject>Cystatin C - metabolism</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>major burn</subject><subject>Male</subject><subject>microalbuminuria</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Statistics as Topic</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDlPxDAQhS0EguUo-APIJRQBH7Fjl2hZDgmBxCFKy-tMhCHJLnYsyL_HsEDHTDHFfO9J7yG0T8kxzXMCzh9TVgq2hiaUS1EwLtk6mhBCy4Lpim2h7RhfCCGKcraJtphQmnGhJuj2HkLqsBvjYAff4ym2fY0778LCtvPU-T4Fb3H-zFPo8TJD0A8Rv_vhGVuXBsCvvu5hzMhLCuMu2mhsG2Hv5-6gx_PZw_SyuL69uJqeXheOS84KwYGyRut5ybmUQihQFWG6UU5JqSS4ugYrudKUMqql5KCYa3RTNromwAXfQYcr32VYvCWIg-l8dNC2todFioZKxcq8VZXRoxWaM8UYoDHL4DsbRkOJ-erP5P7Md3-ZPfixTfMO6j_yt7AMnKyAd9_C-L-TmU2vfi2LlcLHAT7-FDa8GlnxSpinmwtTnuX8d7wy5_wTa7WHhw</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Yim, Haejun</creator><creator>Kym, Dohern</creator><creator>Seo, Dong Kook</creator><creator>Yoon, Jaechul</creator><creator>Yang, Hyeong-Tae</creator><creator>Lee, Jeonghwan</creator><creator>Cho, Yong-Suk</creator><creator>Hur, Jun</creator><creator>Chun, Wook</creator><creator>Han, Seong-Woo</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9178-0599</orcidid></search><sort><creationdate>201506</creationdate><title>Serum cystatin C and microalbuminuria in burn patients with acute kidney injury</title><author>Yim, Haejun ; Kym, Dohern ; Seo, Dong Kook ; Yoon, Jaechul ; Yang, Hyeong-Tae ; Lee, Jeonghwan ; Cho, Yong-Suk ; Hur, Jun ; Chun, Wook ; Han, Seong-Woo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3632-53e12f99b43366558e87029f8c86686ecddea638911219663e82cf9f4f9d0e353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute kidney injury</topic><topic>Acute Kidney Injury - diagnosis</topic><topic>Acute Kidney Injury - etiology</topic><topic>Albuminuria - blood</topic><topic>Albuminuria - etiology</topic><topic>Biomarkers - metabolism</topic><topic>Burns - blood</topic><topic>Burns - complications</topic><topic>Burns - urine</topic><topic>Creatinine - metabolism</topic><topic>cystatin C</topic><topic>Cystatin C - metabolism</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>major burn</topic><topic>Male</topic><topic>microalbuminuria</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Statistics as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yim, Haejun</creatorcontrib><creatorcontrib>Kym, Dohern</creatorcontrib><creatorcontrib>Seo, Dong Kook</creatorcontrib><creatorcontrib>Yoon, Jaechul</creatorcontrib><creatorcontrib>Yang, Hyeong-Tae</creatorcontrib><creatorcontrib>Lee, Jeonghwan</creatorcontrib><creatorcontrib>Cho, Yong-Suk</creatorcontrib><creatorcontrib>Hur, Jun</creatorcontrib><creatorcontrib>Chun, Wook</creatorcontrib><creatorcontrib>Han, Seong-Woo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yim, Haejun</au><au>Kym, Dohern</au><au>Seo, Dong Kook</au><au>Yoon, Jaechul</au><au>Yang, Hyeong-Tae</au><au>Lee, Jeonghwan</au><au>Cho, Yong-Suk</au><au>Hur, Jun</au><au>Chun, Wook</au><au>Han, Seong-Woo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum cystatin C and microalbuminuria in burn patients with acute kidney injury</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>Eur J Clin Invest</addtitle><date>2015-06</date><risdate>2015</risdate><volume>45</volume><issue>6</issue><spage>594</spage><epage>600</epage><pages>594-600</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Background
This study was aimed at evaluating the effectiveness of serum cystatin C and microalbuminuria as diagnostic markers for acute kidney injury (AKI) in major burn patients.
Materials and methods
Major burn adult patients admitted to the burn intensive care unit within 24 h from the onset of injury were enrolled. Serum cystatin C and microalbuminuria (albumin–creatinine ratio, ACR) were obtained at postburn days 1, 3, 7, 14, 21 and 28. The patients were divided into two groups of the AKI group and the nonacute kidney injury group.
Results
A total of 97 patients were enrolled in this study. Acute kidney injury was diagnosed in 40 patients (41·2%) at postburn day 17·3 ± 7·9. The area under the curve of the receiver operating characteristic curve for serum cystatin C was 0·808 (95% CI, 0·711–0·905, P < 0·001) at postburn day 7 and 0·908 (95% CI, 0·843–0·973, P < 0·001) at postburn day 14. The results were 0·610 (95% CI, 0·497–0·724, P = 0·069) for ACR at postburn day 7 and 0·694 (95% CI, 0·589–0·798, P = 0·001) at postburn day 14. The optimal cut‐off value of serum cystatin C at postburn day 14 and ACR at postburn day 14 were 0·85 mg/L (sensitivity, 89·5%; specificity, 82·5%) and 41·51 mg/g cre (sensitivity, 60·5%; specificity, 61·4%), respectively. Serum cystatin C at postburn day 14 was the only significant factor in relation to AKI.
Conclusions
Serum cystatin C is a valuable diagnostic marker, whereas microalbuminuria is a relatively less significant marker for AKI in major burn patients.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25892358</pmid><doi>10.1111/eci.12452</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9178-0599</orcidid></addata></record> |
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| subjects | Acute kidney injury Acute Kidney Injury - diagnosis Acute Kidney Injury - etiology Albuminuria - blood Albuminuria - etiology Biomarkers - metabolism Burns - blood Burns - complications Burns - urine Creatinine - metabolism cystatin C Cystatin C - metabolism Early Diagnosis Female Humans major burn Male microalbuminuria Middle Aged Prospective Studies Statistics as Topic |
| title | Serum cystatin C and microalbuminuria in burn patients with acute kidney injury |
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