Cytokine profile of viral and autoimmune chronic active hepatitis
Background: Patients with hepatitis have multiple immunologic abnormalities, which may be related to cytokine production. Methods: We examined the in vitro production of interleukins (IL-2, IL-4, IL-6), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) in purified peripheral blood mononuclea...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 1993-12, Vol.92 (6), p.902-908 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Al-Wabel, Abdulhamid Al-Janadi, Mansour Raziuddin, Syed |
| description | Background:
Patients with hepatitis have multiple immunologic abnormalities, which may be related to cytokine production.
Methods:
We examined the in vitro production of interleukins (IL-2, IL-4, IL-6), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) in purified peripheral blood mononuclear cells (PBMCs) of patients with hepatitis B virus positive (HBV), acute viral hepatitis (A-HBV), HBV + chronic active hepatitis (HBV-CAH), and autoimmune-type chronic active hepatitis (AI-ACH).
Results:
IFN-γ and TNF-α production were characteristically higher in patients with A-HBV than in healthy control subjects (
p < 0.001). However, patients with AI-CAH produced highly elevated levels of IL-4 and IL-6 compared with patients with A-HBV and HBV-CAH and healthy control subjects. The cytokine profile (PBMC-induced IL-2, IL-4, IL-6, IFN-γ, and TNF-α production) is different in A-HBV, HBV-CAH, and AI-CAH disease. The increased cytokine secretion (IFN-γ and TNF-α in A-HBV and IL-4 and IL-6 in AI-CAH) could reflect altered relative frequencies of different cell phenotypes in these diseases.
Conclusion:
Specific eytokine production may be important in the pathophysiology associated with diverse inflammatory states in patients with hepatitis. |
| doi_str_mv | 10.1016/0091-6749(93)90068-Q |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16822974</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>009167499390068Q</els_id><sourcerecordid>16822974</sourcerecordid><originalsourceid>FETCH-LOGICAL-c483t-586c15726e6ab5626a6359a8835c298028d4ae89ee67c489062231810eec47ab3</originalsourceid><addsrcrecordid>eNp9kMtKAzEUhoMotVbfQGEWIroYzWUmk2yEUrxBQQq6DmnmDI3OpSaZQt_e1A5dugrh__6Tkw-hS4LvCSb8AWNJUl5k8layO4kxF-niCI0JlkXKBc2P0fiAnKIz779wvDMhR2gUY8FpNkbT2TZ037aFZO26ytaQdFWysU7XiW7LRPehs03Tx9ysXNdak2gT7AaSFax1sMH6c3RS6drDxXBO0Ofz08fsNZ2_v7zNpvPUZIKFNL5nSF5QDlwvc0655iyXWgiWGyoFpqLMNAgJwIvYkJhTyoggGMBkhV6yCbrZz42L_vTgg2qsN1DXuoWu94rEP1NZZBHM9qBxnfcOKrV2ttFuqwhWO3Nqp0XttCjJ1J85tYi1q2F-v2ygPJQGVTG_HnLtja4rp1tj_QFjIiO4IBF73GMQXWwsOOWNhdZAaR2YoMrO_r_HL0TWiOU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16822974</pqid></control><display><type>article</type><title>Cytokine profile of viral and autoimmune chronic active hepatitis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Al-Wabel, Abdulhamid ; Al-Janadi, Mansour ; Raziuddin, Syed</creator><creatorcontrib>Al-Wabel, Abdulhamid ; Al-Janadi, Mansour ; Raziuddin, Syed</creatorcontrib><description>Background:
Patients with hepatitis have multiple immunologic abnormalities, which may be related to cytokine production.
Methods:
We examined the in vitro production of interleukins (IL-2, IL-4, IL-6), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) in purified peripheral blood mononuclear cells (PBMCs) of patients with hepatitis B virus positive (HBV), acute viral hepatitis (A-HBV), HBV + chronic active hepatitis (HBV-CAH), and autoimmune-type chronic active hepatitis (AI-ACH).
Results:
IFN-γ and TNF-α production were characteristically higher in patients with A-HBV than in healthy control subjects (
p < 0.001). However, patients with AI-CAH produced highly elevated levels of IL-4 and IL-6 compared with patients with A-HBV and HBV-CAH and healthy control subjects. The cytokine profile (PBMC-induced IL-2, IL-4, IL-6, IFN-γ, and TNF-α production) is different in A-HBV, HBV-CAH, and AI-CAH disease. The increased cytokine secretion (IFN-γ and TNF-α in A-HBV and IL-4 and IL-6 in AI-CAH) could reflect altered relative frequencies of different cell phenotypes in these diseases.
Conclusion:
Specific eytokine production may be important in the pathophysiology associated with diverse inflammatory states in patients with hepatitis.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/0091-6749(93)90068-Q</identifier><identifier>PMID: 8258624</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Autoimmune Diseases - immunology ; autoimmune-type chronic active hepatitis ; Biological and medical sciences ; Calcimycin - pharmacology ; Concanavalin A - pharmacology ; cytokines ; Cytokines - biosynthesis ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis B - immunology ; Hepatitis B virus ; Hepatitis, Chronic - immunology ; Humans ; In Vitro Techniques ; Interferon-gamma - biosynthesis ; interferon-γ tumor necrosis factor-α ; Interleukin-2 - biosynthesis ; Interleukin-4 - biosynthesis ; Interleukin-6 - biosynthesis ; interleukins ; Leukocytes, Mononuclear - drug effects ; Leukocytes, Mononuclear - immunology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Other diseases. Semiology ; Tetradecanoylphorbol Acetate - pharmacology ; Tumor Necrosis Factor-alpha - biosynthesis</subject><ispartof>Journal of allergy and clinical immunology, 1993-12, Vol.92 (6), p.902-908</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-586c15726e6ab5626a6359a8835c298028d4ae89ee67c489062231810eec47ab3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-6749(93)90068-Q$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3841071$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8258624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Wabel, Abdulhamid</creatorcontrib><creatorcontrib>Al-Janadi, Mansour</creatorcontrib><creatorcontrib>Raziuddin, Syed</creatorcontrib><title>Cytokine profile of viral and autoimmune chronic active hepatitis</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background:
Patients with hepatitis have multiple immunologic abnormalities, which may be related to cytokine production.
Methods:
We examined the in vitro production of interleukins (IL-2, IL-4, IL-6), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) in purified peripheral blood mononuclear cells (PBMCs) of patients with hepatitis B virus positive (HBV), acute viral hepatitis (A-HBV), HBV + chronic active hepatitis (HBV-CAH), and autoimmune-type chronic active hepatitis (AI-ACH).
Results:
IFN-γ and TNF-α production were characteristically higher in patients with A-HBV than in healthy control subjects (
p < 0.001). However, patients with AI-CAH produced highly elevated levels of IL-4 and IL-6 compared with patients with A-HBV and HBV-CAH and healthy control subjects. The cytokine profile (PBMC-induced IL-2, IL-4, IL-6, IFN-γ, and TNF-α production) is different in A-HBV, HBV-CAH, and AI-CAH disease. The increased cytokine secretion (IFN-γ and TNF-α in A-HBV and IL-4 and IL-6 in AI-CAH) could reflect altered relative frequencies of different cell phenotypes in these diseases.
Conclusion:
Specific eytokine production may be important in the pathophysiology associated with diverse inflammatory states in patients with hepatitis.</description><subject>Adult</subject><subject>Autoimmune Diseases - immunology</subject><subject>autoimmune-type chronic active hepatitis</subject><subject>Biological and medical sciences</subject><subject>Calcimycin - pharmacology</subject><subject>Concanavalin A - pharmacology</subject><subject>cytokines</subject><subject>Cytokines - biosynthesis</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis B virus</subject><subject>Hepatitis, Chronic - immunology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Interferon-gamma - biosynthesis</subject><subject>interferon-γ tumor necrosis factor-α</subject><subject>Interleukin-2 - biosynthesis</subject><subject>Interleukin-4 - biosynthesis</subject><subject>Interleukin-6 - biosynthesis</subject><subject>interleukins</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMotVbfQGEWIroYzWUmk2yEUrxBQQq6DmnmDI3OpSaZQt_e1A5dugrh__6Tkw-hS4LvCSb8AWNJUl5k8layO4kxF-niCI0JlkXKBc2P0fiAnKIz779wvDMhR2gUY8FpNkbT2TZ037aFZO26ytaQdFWysU7XiW7LRPehs03Tx9ysXNdak2gT7AaSFax1sMH6c3RS6drDxXBO0Ofz08fsNZ2_v7zNpvPUZIKFNL5nSF5QDlwvc0655iyXWgiWGyoFpqLMNAgJwIvYkJhTyoggGMBkhV6yCbrZz42L_vTgg2qsN1DXuoWu94rEP1NZZBHM9qBxnfcOKrV2ttFuqwhWO3Nqp0XttCjJ1J85tYi1q2F-v2ygPJQGVTG_HnLtja4rp1tj_QFjIiO4IBF73GMQXWwsOOWNhdZAaR2YoMrO_r_HL0TWiOU</recordid><startdate>19931201</startdate><enddate>19931201</enddate><creator>Al-Wabel, Abdulhamid</creator><creator>Al-Janadi, Mansour</creator><creator>Raziuddin, Syed</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>19931201</creationdate><title>Cytokine profile of viral and autoimmune chronic active hepatitis</title><author>Al-Wabel, Abdulhamid ; Al-Janadi, Mansour ; Raziuddin, Syed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-586c15726e6ab5626a6359a8835c298028d4ae89ee67c489062231810eec47ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Autoimmune Diseases - immunology</topic><topic>autoimmune-type chronic active hepatitis</topic><topic>Biological and medical sciences</topic><topic>Calcimycin - pharmacology</topic><topic>Concanavalin A - pharmacology</topic><topic>cytokines</topic><topic>Cytokines - biosynthesis</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatitis B - immunology</topic><topic>Hepatitis B virus</topic><topic>Hepatitis, Chronic - immunology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Interferon-gamma - biosynthesis</topic><topic>interferon-γ tumor necrosis factor-α</topic><topic>Interleukin-2 - biosynthesis</topic><topic>Interleukin-4 - biosynthesis</topic><topic>Interleukin-6 - biosynthesis</topic><topic>interleukins</topic><topic>Leukocytes, Mononuclear - drug effects</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Wabel, Abdulhamid</creatorcontrib><creatorcontrib>Al-Janadi, Mansour</creatorcontrib><creatorcontrib>Raziuddin, Syed</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Wabel, Abdulhamid</au><au>Al-Janadi, Mansour</au><au>Raziuddin, Syed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokine profile of viral and autoimmune chronic active hepatitis</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>1993-12-01</date><risdate>1993</risdate><volume>92</volume><issue>6</issue><spage>902</spage><epage>908</epage><pages>902-908</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Background:
Patients with hepatitis have multiple immunologic abnormalities, which may be related to cytokine production.
Methods:
We examined the in vitro production of interleukins (IL-2, IL-4, IL-6), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) in purified peripheral blood mononuclear cells (PBMCs) of patients with hepatitis B virus positive (HBV), acute viral hepatitis (A-HBV), HBV + chronic active hepatitis (HBV-CAH), and autoimmune-type chronic active hepatitis (AI-ACH).
Results:
IFN-γ and TNF-α production were characteristically higher in patients with A-HBV than in healthy control subjects (
p < 0.001). However, patients with AI-CAH produced highly elevated levels of IL-4 and IL-6 compared with patients with A-HBV and HBV-CAH and healthy control subjects. The cytokine profile (PBMC-induced IL-2, IL-4, IL-6, IFN-γ, and TNF-α production) is different in A-HBV, HBV-CAH, and AI-CAH disease. The increased cytokine secretion (IFN-γ and TNF-α in A-HBV and IL-4 and IL-6 in AI-CAH) could reflect altered relative frequencies of different cell phenotypes in these diseases.
Conclusion:
Specific eytokine production may be important in the pathophysiology associated with diverse inflammatory states in patients with hepatitis.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>8258624</pmid><doi>10.1016/0091-6749(93)90068-Q</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Autoimmune Diseases - immunology autoimmune-type chronic active hepatitis Biological and medical sciences Calcimycin - pharmacology Concanavalin A - pharmacology cytokines Cytokines - biosynthesis Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis B - immunology Hepatitis B virus Hepatitis, Chronic - immunology Humans In Vitro Techniques Interferon-gamma - biosynthesis interferon-γ tumor necrosis factor-α Interleukin-2 - biosynthesis Interleukin-4 - biosynthesis Interleukin-6 - biosynthesis interleukins Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Other diseases. Semiology Tetradecanoylphorbol Acetate - pharmacology Tumor Necrosis Factor-alpha - biosynthesis |
| title | Cytokine profile of viral and autoimmune chronic active hepatitis |
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