S100A9 promotes human hepatocellular carcinoma cell growth and invasion through RAGE-mediated ERK1/2 and p38 MAPK pathways

S100A9 belongs to the S100 family of calcium-binding proteins and is over-expressed in many human tumors including hepatocellular carcinoma (HCC). Recent study demonstrated that S100A9 is significantly elevated and is associated with tumor differentiation and vascular invasion in HCC. The functional...

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Veröffentlicht in:	Experimental cell research 2015-06, Vol.334 (2), p.228-238
Hauptverfasser:	Wu, Rui, Duan, Liang, Cui, Fang, Cao, Ju, Xiang, Yu, Tang, Yishu, Zhou, Lan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calgranulin B - metabolism Cancer Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Proliferation Cells, Cultured Cellular biology Disease Models, Animal Female Growth Hep G2 Cells Hepatocellular carcinoma Humans Invasion Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms, Experimental - metabolism Liver Neoplasms, Experimental - pathology MAP Kinase Signaling System Mice Mice, Nude Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Neoplasm Invasiveness - pathology p38 Mitogen-Activated Protein Kinases - metabolism Receptor for Advanced Glycation End Products Receptors, Immunologic - metabolism Rodents S100A9 Studies Tumors
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