See-through Brains and Diffusion Tensor MRI Clarified Fiber Connections: A Preliminary Microstructural Study in a Mouse with Callosal Agenesis
Clearing methods that render the brain optically transparent allow high-resolution three-dimensional (3D) imaging of neural networks. We used diffusion tensor imaging (DTI) and two-photon imaging of cleared brains to analyze white matter in BTBR mice. We confirmed corpus callosum agenesis and identi...
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| Veröffentlicht in: | Magnetic Resonance in Medical Sciences 2015, Vol.14(2), pp.159-162 |
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| creator | KEREVER, Aurelien KAMAGATA, Koji YOKOSAWA, Suguru OTAKE, Yosuke OCHI, Hisaaki YAMADA, Taihei HORI, Masaaki KAMIYA, Kouhei NISHIKORI, Akira AOKI, Shigeki ARIKAWA-HIRASAWA, Eri |
| description | Clearing methods that render the brain optically transparent allow high-resolution three-dimensional (3D) imaging of neural networks. We used diffusion tensor imaging (DTI) and two-photon imaging of cleared brains to analyze white matter in BTBR mice. We confirmed corpus callosum agenesis and identified an abnormal commissure close to the third ventricle. DTI and cleared-brain two-photon imaging revealed that these commissural fibers constituted a frontal clustering of the ventral hippocampal commissure and provided a detailed assessment of white matter structure in mice. |
| doi_str_mv | 10.2463/mrms.2014-0142 |
| format | Article |
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We used diffusion tensor imaging (DTI) and two-photon imaging of cleared brains to analyze white matter in BTBR mice. We confirmed corpus callosum agenesis and identified an abnormal commissure close to the third ventricle. 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We used diffusion tensor imaging (DTI) and two-photon imaging of cleared brains to analyze white matter in BTBR mice. We confirmed corpus callosum agenesis and identified an abnormal commissure close to the third ventricle. DTI and cleared-brain two-photon imaging revealed that these commissural fibers constituted a frontal clustering of the ventral hippocampal commissure and provided a detailed assessment of white matter structure in mice.</description><subject>Agenesis of Corpus Callosum - pathology</subject><subject>Animals</subject><subject>Brain - abnormalities</subject><subject>Brain - anatomy & histology</subject><subject>Brain - pathology</subject><subject>CLARITY</subject><subject>cleared brain</subject><subject>Corpus Callosum - pathology</subject><subject>CUBIC</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>diffusion tensor imaging</subject><subject>Diffusion Tensor Imaging - methods</subject><subject>Disease Models, Animal</subject><subject>Fornix, Brain - pathology</subject><subject>Hippocampus - pathology</subject><subject>Histocytological Preparation Techniques - methods</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred Strains</subject><subject>Microtomy - methods</subject><subject>Nerve Net - pathology</subject><subject>Third Ventricle - pathology</subject><subject>Tissue Fixation - methods</subject><subject>White Matter - pathology</subject><issn>1347-3182</issn><issn>1880-2206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU9v3CAQxVHVKkmTXHusOPbiLQb_wb1tnSaNlFWrJjkjwMMuEcYpYEX5Ev3MxdlkDwxI7zdPzDyEPpVkRauGfR3DGFeUlFWRD32HTkrOSUEpad7nN6vagpWcHqOPMT4QwniWj9AxrTljtCUn6N8tQJF2YZq3O_w9SOsjln7AF9aYOdrJ4zvwcQp48-ca904GaywM-NIqCLifvAedMhW_4TX-HcDZ0XoZnvHG6jDFFGad5iAdvk3z8IytxxJvpjkCfrJph3vp3BSzvN6Ch2jjGfpgpItw_nqfovvLH3f9z-Lm19V1v74pdMWbVChKWtM0NTftwE3XUdm1UEqjqGy47JhqK8oU1ao0La-V1qZThFeEg65r2VTsFH3Z-z6G6e8MMYnRRg3OSQ_5e6JseN5hTVuW0dUeXQaKAYx4DHbMM4qSiCUDsWQglgzEkkFu-PzqPasRhgP-tvQMXOyBh5jkFg6ADMlqB3u_7EZfypvvQdY7GQR49h9Zq5zA</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>KEREVER, Aurelien</creator><creator>KAMAGATA, Koji</creator><creator>YOKOSAWA, Suguru</creator><creator>OTAKE, Yosuke</creator><creator>OCHI, Hisaaki</creator><creator>YAMADA, Taihei</creator><creator>HORI, Masaaki</creator><creator>KAMIYA, Kouhei</creator><creator>NISHIKORI, Akira</creator><creator>AOKI, Shigeki</creator><creator>ARIKAWA-HIRASAWA, Eri</creator><general>Japanese Society for Magnetic Resonance in Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>See-through Brains and Diffusion Tensor MRI Clarified Fiber Connections: A Preliminary Microstructural Study in a Mouse with Callosal Agenesis</title><author>KEREVER, Aurelien ; 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| subjects | Agenesis of Corpus Callosum - pathology Animals Brain - abnormalities Brain - anatomy & histology Brain - pathology CLARITY cleared brain Corpus Callosum - pathology CUBIC Diffusion Magnetic Resonance Imaging - methods diffusion tensor imaging Diffusion Tensor Imaging - methods Disease Models, Animal Fornix, Brain - pathology Hippocampus - pathology Histocytological Preparation Techniques - methods Image Processing, Computer-Assisted - methods Imaging, Three-Dimensional - methods Male Mice Mice, Inbred C57BL Mice, Inbred Strains Microtomy - methods Nerve Net - pathology Third Ventricle - pathology Tissue Fixation - methods White Matter - pathology |
| title | See-through Brains and Diffusion Tensor MRI Clarified Fiber Connections: A Preliminary Microstructural Study in a Mouse with Callosal Agenesis |
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