Evaluation of absolute and normalized apparent diffusion coefficient (ADC) values within the post-operative T2/FLAIR volume as adverse prognostic indicators in glioblastoma
To evaluate the association of normalized and absolute ADC metrics with progression free survival (PFS) and overall survival (OS) in patients treated for glioblastoma multiforme (GBM). Fifty-two patients with preradiotherapy diffusion weighted imaging treated with post-operative chemoradiation for G...
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Veröffentlicht in: | Journal of neuro-oncology 2015-05, Vol.122 (3), p.549-558 |
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creator | Elson, Andrew Bovi, Joseph Siker, Malika Schultz, Chris Paulson, Eric |
description | To evaluate the association of normalized and absolute ADC metrics with progression free survival (PFS) and overall survival (OS) in patients treated for glioblastoma multiforme (GBM). Fifty-two patients with preradiotherapy diffusion weighted imaging treated with post-operative chemoradiation for GBM were evaluated. Region of interest analysis for ADC metrics including mean and minimum ADC value (ADC
mean
) and (ADC
min
) was performed within the T2/FLAIR volume. Normalized
(N)
ADC values were generated relative to contralateral white matter. PFS and OS were analyzed relative to ADC parameters using a regression model. Kaplan–Meier and Cox proportional hazards analysis with respect to
(N)
ADC
mean
, and
(N)
ADC
min
was performed. A
(N)
ADC threshold |
doi_str_mv | 10.1007/s11060-015-1743-z |
format | Article |
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mean
) and (ADC
min
) was performed within the T2/FLAIR volume. Normalized
(N)
ADC values were generated relative to contralateral white matter. PFS and OS were analyzed relative to ADC parameters using a regression model. Kaplan–Meier and Cox proportional hazards analysis with respect to
(N)
ADC
mean
, and
(N)
ADC
min
was performed. A
(N)
ADC threshold <1.3 within the T2/FLAIR volume was analyzed with respect to PFS and OS. Regression analysis indicated that normalized ADC values provide the strongest association with PFS and OS. Kaplan–Meier analysis revealed a non-significant trend toward inferior PFS and OS associated with
(N)
ADC
mean
<1.7, and a significant decrement to PFS and OS associated with
(N)
ADC
min
<0.3.
(N)
ADC
min
was a significant prognostic factor when taking into account age, performance status, and extent of resection. ADC thresholding analysis revealed that a retained volume of >0.45 cc per mL FLAIR volume was associated with a trend toward inferior PFS and OS. In the post-operative, pre-radiotherapy setting, the
(N)
ADC
min
is the strongest predictor of outcomes in patients treated for GBM. ADC thresholding analysis indicates that a large volume of normalized ADC value <1.3 may be associated with adverse outcomes.</description><identifier>ISSN: 0167-594X</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1007/s11060-015-1743-z</identifier><identifier>PMID: 25700835</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Brain Neoplasms - diagnosis ; Brain Neoplasms - surgery ; Clinical Study ; Diffusion Magnetic Resonance Imaging ; Disease-Free Survival ; Female ; Follow-Up Studies ; Glioblastoma - diagnosis ; Glioblastoma - surgery ; Humans ; Image Processing, Computer-Assisted ; Kaplan-Meier Estimate ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Recurrence, Local ; Neurology ; Oncology ; Regression Analysis ; Treatment Outcome</subject><ispartof>Journal of neuro-oncology, 2015-05, Vol.122 (3), p.549-558</ispartof><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-85dfea8c5d3d8cf82e93f88adec071ae72e596392ced13f072ab0893110920ed3</citedby><cites>FETCH-LOGICAL-c438t-85dfea8c5d3d8cf82e93f88adec071ae72e596392ced13f072ab0893110920ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11060-015-1743-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11060-015-1743-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25700835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elson, Andrew</creatorcontrib><creatorcontrib>Bovi, Joseph</creatorcontrib><creatorcontrib>Siker, Malika</creatorcontrib><creatorcontrib>Schultz, Chris</creatorcontrib><creatorcontrib>Paulson, Eric</creatorcontrib><title>Evaluation of absolute and normalized apparent diffusion coefficient (ADC) values within the post-operative T2/FLAIR volume as adverse prognostic indicators in glioblastoma</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><addtitle>J Neurooncol</addtitle><description>To evaluate the association of normalized and absolute ADC metrics with progression free survival (PFS) and overall survival (OS) in patients treated for glioblastoma multiforme (GBM). Fifty-two patients with preradiotherapy diffusion weighted imaging treated with post-operative chemoradiation for GBM were evaluated. Region of interest analysis for ADC metrics including mean and minimum ADC value (ADC
mean
) and (ADC
min
) was performed within the T2/FLAIR volume. Normalized
(N)
ADC values were generated relative to contralateral white matter. PFS and OS were analyzed relative to ADC parameters using a regression model. Kaplan–Meier and Cox proportional hazards analysis with respect to
(N)
ADC
mean
, and
(N)
ADC
min
was performed. A
(N)
ADC threshold <1.3 within the T2/FLAIR volume was analyzed with respect to PFS and OS. Regression analysis indicated that normalized ADC values provide the strongest association with PFS and OS. Kaplan–Meier analysis revealed a non-significant trend toward inferior PFS and OS associated with
(N)
ADC
mean
<1.7, and a significant decrement to PFS and OS associated with
(N)
ADC
min
<0.3.
(N)
ADC
min
was a significant prognostic factor when taking into account age, performance status, and extent of resection. ADC thresholding analysis revealed that a retained volume of >0.45 cc per mL FLAIR volume was associated with a trend toward inferior PFS and OS. In the post-operative, pre-radiotherapy setting, the
(N)
ADC
min
is the strongest predictor of outcomes in patients treated for GBM. ADC thresholding analysis indicates that a large volume of normalized ADC value <1.3 may be associated with adverse outcomes.</description><subject>Aged</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - surgery</subject><subject>Clinical Study</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glioblastoma - diagnosis</subject><subject>Glioblastoma - surgery</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neurology</subject><subject>Oncology</subject><subject>Regression Analysis</subject><subject>Treatment Outcome</subject><issn>0167-594X</issn><issn>1573-7373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kd9qFDEUxgdR7Fp9AG8k4E29GJs_k0nmcllbLSwIUsG7IZucbFNmkjHJbHGfyYc0w1YRwasckt_5vpPzVdVrgt8TjMVlIgS3uMaE10Q0rD4-qVaEC1YLJtjTaoVJK2reNd_Oqhcp3WOMG8HI8-qMcoGxZHxV_bw6qGFW2QWPgkVql8IwZ0DKG-RDHNXgjmCQmiYVwWdknLVzWmgdwFqn3XJ7sf6weYcWJUjoweU751G-AzSFlOswQSwGB0C39PJ6u775gg7FZCwmCSlzgJgKGcPeF9pp5LxxWuUQUynRfnBhN6iUw6heVs-sGhK8ejzPq6_XV7ebT_X288ebzXpb64bJXEtuLCipuWFGaispdMxKqQxoLIgCQYF3LeuoBkOYxYKqHZYdK9vsKAbDzquLk26Z6nv5Uu5HlzQMg_IQ5tSTVlKKOeZdQd_-g96HOfoy3UKRpmnbZqHIidIxpBTB9lN0o4o_eoL7Jcr-FGVfouyXKPtj6XnzqDzvRjB_On5nVwB6AlJ58nuIf1n_V_UXLCatEw</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Elson, Andrew</creator><creator>Bovi, Joseph</creator><creator>Siker, Malika</creator><creator>Schultz, Chris</creator><creator>Paulson, Eric</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20150501</creationdate><title>Evaluation of absolute and normalized apparent diffusion coefficient (ADC) values within the post-operative T2/FLAIR volume as adverse prognostic indicators in glioblastoma</title><author>Elson, Andrew ; Bovi, Joseph ; Siker, Malika ; Schultz, Chris ; Paulson, Eric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-85dfea8c5d3d8cf82e93f88adec071ae72e596392ced13f072ab0893110920ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - surgery</topic><topic>Clinical Study</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glioblastoma - diagnosis</topic><topic>Glioblastoma - surgery</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neurology</topic><topic>Oncology</topic><topic>Regression Analysis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elson, Andrew</creatorcontrib><creatorcontrib>Bovi, Joseph</creatorcontrib><creatorcontrib>Siker, Malika</creatorcontrib><creatorcontrib>Schultz, Chris</creatorcontrib><creatorcontrib>Paulson, Eric</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuro-oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elson, Andrew</au><au>Bovi, Joseph</au><au>Siker, Malika</au><au>Schultz, Chris</au><au>Paulson, Eric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of absolute and normalized apparent diffusion coefficient (ADC) values within the post-operative T2/FLAIR volume as adverse prognostic indicators in glioblastoma</atitle><jtitle>Journal of neuro-oncology</jtitle><stitle>J Neurooncol</stitle><addtitle>J Neurooncol</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>122</volume><issue>3</issue><spage>549</spage><epage>558</epage><pages>549-558</pages><issn>0167-594X</issn><eissn>1573-7373</eissn><abstract>To evaluate the association of normalized and absolute ADC metrics with progression free survival (PFS) and overall survival (OS) in patients treated for glioblastoma multiforme (GBM). Fifty-two patients with preradiotherapy diffusion weighted imaging treated with post-operative chemoradiation for GBM were evaluated. Region of interest analysis for ADC metrics including mean and minimum ADC value (ADC
mean
) and (ADC
min
) was performed within the T2/FLAIR volume. Normalized
(N)
ADC values were generated relative to contralateral white matter. PFS and OS were analyzed relative to ADC parameters using a regression model. Kaplan–Meier and Cox proportional hazards analysis with respect to
(N)
ADC
mean
, and
(N)
ADC
min
was performed. A
(N)
ADC threshold <1.3 within the T2/FLAIR volume was analyzed with respect to PFS and OS. Regression analysis indicated that normalized ADC values provide the strongest association with PFS and OS. Kaplan–Meier analysis revealed a non-significant trend toward inferior PFS and OS associated with
(N)
ADC
mean
<1.7, and a significant decrement to PFS and OS associated with
(N)
ADC
min
<0.3.
(N)
ADC
min
was a significant prognostic factor when taking into account age, performance status, and extent of resection. ADC thresholding analysis revealed that a retained volume of >0.45 cc per mL FLAIR volume was associated with a trend toward inferior PFS and OS. In the post-operative, pre-radiotherapy setting, the
(N)
ADC
min
is the strongest predictor of outcomes in patients treated for GBM. ADC thresholding analysis indicates that a large volume of normalized ADC value <1.3 may be associated with adverse outcomes.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25700835</pmid><doi>10.1007/s11060-015-1743-z</doi><tpages>10</tpages></addata></record> |
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source | MEDLINE; SpringerLink Journals - AutoHoldings |
subjects | Aged Brain Neoplasms - diagnosis Brain Neoplasms - surgery Clinical Study Diffusion Magnetic Resonance Imaging Disease-Free Survival Female Follow-Up Studies Glioblastoma - diagnosis Glioblastoma - surgery Humans Image Processing, Computer-Assisted Kaplan-Meier Estimate Male Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local Neurology Oncology Regression Analysis Treatment Outcome |
title | Evaluation of absolute and normalized apparent diffusion coefficient (ADC) values within the post-operative T2/FLAIR volume as adverse prognostic indicators in glioblastoma |
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