Nanoparticulate anatase TiO2 (TiO2 NPs) upregulates the expression of silkworm (Bombyx mori) neuropeptide receptor and promotes silkworm feeding, growth, and silking
•TiO2 NPs affect B. mori feeding and growth through increasing the expression of BmNPFR.•TiO2 NPs enhance BmNPFR binding to its ligands BmNPF1a and BmNPF1b.•BmNPFR is the primary and core target of TiO2 NPs’ promotion of B. mori growth and development.•TiO2 NPs have dose-dependent effects in differe...
Gespeichert in:
| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2015-06, Vol.68, p.64-71 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 71 |
|---|---|
| container_issue | |
| container_start_page | 64 |
| container_title | Peptides (New York, N.Y. : 1980) |
| container_volume | 68 |
| creator | Ni, Min Zhang, Hua Li, Fan Chi Wang, Bin Bin Xu, Kai Zun Shen, Wei De Li, Bing |
| description | •TiO2 NPs affect B. mori feeding and growth through increasing the expression of BmNPFR.•TiO2 NPs enhance BmNPFR binding to its ligands BmNPF1a and BmNPF1b.•BmNPFR is the primary and core target of TiO2 NPs’ promotion of B. mori growth and development.•TiO2 NPs have dose-dependent effects in different organs.
Bombyx mori orphan G protein-coupled receptor, BNGR-A4, is the specific receptor of B. mori neuropeptide F (BmNPFR, neuropeptide F designated NPF). BmNPFR binds specifically and efficiently to B. mori neuropeptides BmNPF1a and BmNPF1b, which activates the ERK1/2 signaling pathway to regulate B. mori food intake and growth. Titanium dioxide nanoparticles (TiO2 NPs) can promote B. mori growth. However, whether the mechanisms of TiO2 NPs’ effects are correlated with BmNPFR remains unknown. In this study, the effects of TiO2 NPs (5mg/L) feeding and BmNPFR-dsRNA injection on B. mori food intake and growth were investigated; after TiO2 NPs treatments, B. mori food intake, body weight, and cocoon shell weight were 5.82%, 4.64%, and 9.30% higher, respectively, than those of controls. The food intake, body weight, and cocoon shell weight of the BmNPFR-dsRNA injection group were reduced by 8.05%, 6.28%, and 6.98%, respectively, compared to the control. After TiO2 NPs treatment for 72h, the transcriptional levels of BmNPFR, BmNPF1a, and BmNPF1b in the midgut were 1.58, 1.43, and 1.34-folds, respectively, of those of the control, but 1.99, 2.26, and 2.19-folds, respectively, of the BmNPFR-dsRNA injection group; the phosphorylation level of MAPK was 24.03% higher than the control, while the phosphorylation level of BmNPFR-dsRNA injection group was 71.00% of control. The results indicated that TiO2 NPs affect B. mori feeding and growth through increasing the expression of BmNPFR. This study helps clarify the roles of BmNPF/BmNPFR system in TiO2 NPs’ effects on B. mori feeding, growth, and development. |
| doi_str_mv | 10.1016/j.peptides.2014.12.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1681916495</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0196978115000091</els_id><sourcerecordid>1681916495</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-ed95b2d317ed882c444aff3621a6ae63a7be84dc7a0134b7cb41aeeaa71aca2f3</originalsourceid><addsrcrecordid>eNqFUU1P3DAQtVAr2FL-AvJxkUjqSbxOcmuL-iUh6IGerYkzWbwkcWonBX5Q_2e9H3Dtxc8avzdvPI-xcxApCFAfNulI42QbCmkmQKaQpRGO2ALKIk9WoKo3bCGgUklVlHDC3oWwEUJIWZXH7CRbqVxJIRfs7w0ObkQ_WTN3OBHHAScMxO_sbcaXu_PmZ7jg8-hpvaMEPt0Tp6dYCMG6gbuWB9s9PDrf8-Vn19fPT7x33l7wgWbvDoNyTybenI8WDR-9692216uyJWrssL7ka-8ep_vLHW37Govv2dsWu0BnBzxlv75-ubv6nlzffvtx9ek6MTIvp4SaalVnTQ4FNWWZGSkltm2uMkCFpHIsaiplYwoUkMu6MLUEJEIsAA1mbX7Klvu-cbzfM4VJ9zYY6jocyM1BgyqhAiWrVaSqPdV4F4KnVo_e9uifNQi9jUhv9EtEehuRhkxHiMLzg8dc99S8yl4yiYSPewLFn_6x5HUwlgYT1xNXOOnG2f95_APy1Kpl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1681916495</pqid></control><display><type>article</type><title>Nanoparticulate anatase TiO2 (TiO2 NPs) upregulates the expression of silkworm (Bombyx mori) neuropeptide receptor and promotes silkworm feeding, growth, and silking</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Ni, Min ; Zhang, Hua ; Li, Fan Chi ; Wang, Bin Bin ; Xu, Kai Zun ; Shen, Wei De ; Li, Bing</creator><creatorcontrib>Ni, Min ; Zhang, Hua ; Li, Fan Chi ; Wang, Bin Bin ; Xu, Kai Zun ; Shen, Wei De ; Li, Bing</creatorcontrib><description>•TiO2 NPs affect B. mori feeding and growth through increasing the expression of BmNPFR.•TiO2 NPs enhance BmNPFR binding to its ligands BmNPF1a and BmNPF1b.•BmNPFR is the primary and core target of TiO2 NPs’ promotion of B. mori growth and development.•TiO2 NPs have dose-dependent effects in different organs.
Bombyx mori orphan G protein-coupled receptor, BNGR-A4, is the specific receptor of B. mori neuropeptide F (BmNPFR, neuropeptide F designated NPF). BmNPFR binds specifically and efficiently to B. mori neuropeptides BmNPF1a and BmNPF1b, which activates the ERK1/2 signaling pathway to regulate B. mori food intake and growth. Titanium dioxide nanoparticles (TiO2 NPs) can promote B. mori growth. However, whether the mechanisms of TiO2 NPs’ effects are correlated with BmNPFR remains unknown. In this study, the effects of TiO2 NPs (5mg/L) feeding and BmNPFR-dsRNA injection on B. mori food intake and growth were investigated; after TiO2 NPs treatments, B. mori food intake, body weight, and cocoon shell weight were 5.82%, 4.64%, and 9.30% higher, respectively, than those of controls. The food intake, body weight, and cocoon shell weight of the BmNPFR-dsRNA injection group were reduced by 8.05%, 6.28%, and 6.98%, respectively, compared to the control. After TiO2 NPs treatment for 72h, the transcriptional levels of BmNPFR, BmNPF1a, and BmNPF1b in the midgut were 1.58, 1.43, and 1.34-folds, respectively, of those of the control, but 1.99, 2.26, and 2.19-folds, respectively, of the BmNPFR-dsRNA injection group; the phosphorylation level of MAPK was 24.03% higher than the control, while the phosphorylation level of BmNPFR-dsRNA injection group was 71.00% of control. The results indicated that TiO2 NPs affect B. mori feeding and growth through increasing the expression of BmNPFR. This study helps clarify the roles of BmNPF/BmNPFR system in TiO2 NPs’ effects on B. mori feeding, growth, and development.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/j.peptides.2014.12.014</identifier><identifier>PMID: 25636404</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; BmNPFR ; Bombyx - drug effects ; Bombyx - physiology ; Bombyx mori ; Development ; Feeding Behavior ; Gene Expression ; Growth ; Insect Proteins - genetics ; Insect Proteins - metabolism ; Larva - drug effects ; Larva - physiology ; MAP Kinase Signaling System ; Nanoparticles - chemistry ; Particle Size ; Receptors, G-Protein-Coupled - genetics ; Receptors, G-Protein-Coupled - metabolism ; Receptors, Neuropeptide - genetics ; Receptors, Neuropeptide - metabolism ; Silk - biosynthesis ; Silking ; Titanium - chemistry ; Titanium - pharmacology ; Titanium dioxide nanoparticles ; Up-Regulation - drug effects</subject><ispartof>Peptides (New York, N.Y. : 1980), 2015-06, Vol.68, p.64-71</ispartof><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-ed95b2d317ed882c444aff3621a6ae63a7be84dc7a0134b7cb41aeeaa71aca2f3</citedby><cites>FETCH-LOGICAL-c438t-ed95b2d317ed882c444aff3621a6ae63a7be84dc7a0134b7cb41aeeaa71aca2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.peptides.2014.12.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25636404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ni, Min</creatorcontrib><creatorcontrib>Zhang, Hua</creatorcontrib><creatorcontrib>Li, Fan Chi</creatorcontrib><creatorcontrib>Wang, Bin Bin</creatorcontrib><creatorcontrib>Xu, Kai Zun</creatorcontrib><creatorcontrib>Shen, Wei De</creatorcontrib><creatorcontrib>Li, Bing</creatorcontrib><title>Nanoparticulate anatase TiO2 (TiO2 NPs) upregulates the expression of silkworm (Bombyx mori) neuropeptide receptor and promotes silkworm feeding, growth, and silking</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>•TiO2 NPs affect B. mori feeding and growth through increasing the expression of BmNPFR.•TiO2 NPs enhance BmNPFR binding to its ligands BmNPF1a and BmNPF1b.•BmNPFR is the primary and core target of TiO2 NPs’ promotion of B. mori growth and development.•TiO2 NPs have dose-dependent effects in different organs.
Bombyx mori orphan G protein-coupled receptor, BNGR-A4, is the specific receptor of B. mori neuropeptide F (BmNPFR, neuropeptide F designated NPF). BmNPFR binds specifically and efficiently to B. mori neuropeptides BmNPF1a and BmNPF1b, which activates the ERK1/2 signaling pathway to regulate B. mori food intake and growth. Titanium dioxide nanoparticles (TiO2 NPs) can promote B. mori growth. However, whether the mechanisms of TiO2 NPs’ effects are correlated with BmNPFR remains unknown. In this study, the effects of TiO2 NPs (5mg/L) feeding and BmNPFR-dsRNA injection on B. mori food intake and growth were investigated; after TiO2 NPs treatments, B. mori food intake, body weight, and cocoon shell weight were 5.82%, 4.64%, and 9.30% higher, respectively, than those of controls. The food intake, body weight, and cocoon shell weight of the BmNPFR-dsRNA injection group were reduced by 8.05%, 6.28%, and 6.98%, respectively, compared to the control. After TiO2 NPs treatment for 72h, the transcriptional levels of BmNPFR, BmNPF1a, and BmNPF1b in the midgut were 1.58, 1.43, and 1.34-folds, respectively, of those of the control, but 1.99, 2.26, and 2.19-folds, respectively, of the BmNPFR-dsRNA injection group; the phosphorylation level of MAPK was 24.03% higher than the control, while the phosphorylation level of BmNPFR-dsRNA injection group was 71.00% of control. The results indicated that TiO2 NPs affect B. mori feeding and growth through increasing the expression of BmNPFR. This study helps clarify the roles of BmNPF/BmNPFR system in TiO2 NPs’ effects on B. mori feeding, growth, and development.</description><subject>Animals</subject><subject>BmNPFR</subject><subject>Bombyx - drug effects</subject><subject>Bombyx - physiology</subject><subject>Bombyx mori</subject><subject>Development</subject><subject>Feeding Behavior</subject><subject>Gene Expression</subject><subject>Growth</subject><subject>Insect Proteins - genetics</subject><subject>Insect Proteins - metabolism</subject><subject>Larva - drug effects</subject><subject>Larva - physiology</subject><subject>MAP Kinase Signaling System</subject><subject>Nanoparticles - chemistry</subject><subject>Particle Size</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Receptors, Neuropeptide - genetics</subject><subject>Receptors, Neuropeptide - metabolism</subject><subject>Silk - biosynthesis</subject><subject>Silking</subject><subject>Titanium - chemistry</subject><subject>Titanium - pharmacology</subject><subject>Titanium dioxide nanoparticles</subject><subject>Up-Regulation - drug effects</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1P3DAQtVAr2FL-AvJxkUjqSbxOcmuL-iUh6IGerYkzWbwkcWonBX5Q_2e9H3Dtxc8avzdvPI-xcxApCFAfNulI42QbCmkmQKaQpRGO2ALKIk9WoKo3bCGgUklVlHDC3oWwEUJIWZXH7CRbqVxJIRfs7w0ObkQ_WTN3OBHHAScMxO_sbcaXu_PmZ7jg8-hpvaMEPt0Tp6dYCMG6gbuWB9s9PDrf8-Vn19fPT7x33l7wgWbvDoNyTybenI8WDR-9692216uyJWrssL7ka-8ep_vLHW37Govv2dsWu0BnBzxlv75-ubv6nlzffvtx9ek6MTIvp4SaalVnTQ4FNWWZGSkltm2uMkCFpHIsaiplYwoUkMu6MLUEJEIsAA1mbX7Klvu-cbzfM4VJ9zYY6jocyM1BgyqhAiWrVaSqPdV4F4KnVo_e9uifNQi9jUhv9EtEehuRhkxHiMLzg8dc99S8yl4yiYSPewLFn_6x5HUwlgYT1xNXOOnG2f95_APy1Kpl</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Ni, Min</creator><creator>Zhang, Hua</creator><creator>Li, Fan Chi</creator><creator>Wang, Bin Bin</creator><creator>Xu, Kai Zun</creator><creator>Shen, Wei De</creator><creator>Li, Bing</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150601</creationdate><title>Nanoparticulate anatase TiO2 (TiO2 NPs) upregulates the expression of silkworm (Bombyx mori) neuropeptide receptor and promotes silkworm feeding, growth, and silking</title><author>Ni, Min ; Zhang, Hua ; Li, Fan Chi ; Wang, Bin Bin ; Xu, Kai Zun ; Shen, Wei De ; Li, Bing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-ed95b2d317ed882c444aff3621a6ae63a7be84dc7a0134b7cb41aeeaa71aca2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>BmNPFR</topic><topic>Bombyx - drug effects</topic><topic>Bombyx - physiology</topic><topic>Bombyx mori</topic><topic>Development</topic><topic>Feeding Behavior</topic><topic>Gene Expression</topic><topic>Growth</topic><topic>Insect Proteins - genetics</topic><topic>Insect Proteins - metabolism</topic><topic>Larva - drug effects</topic><topic>Larva - physiology</topic><topic>MAP Kinase Signaling System</topic><topic>Nanoparticles - chemistry</topic><topic>Particle Size</topic><topic>Receptors, G-Protein-Coupled - genetics</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Receptors, Neuropeptide - genetics</topic><topic>Receptors, Neuropeptide - metabolism</topic><topic>Silk - biosynthesis</topic><topic>Silking</topic><topic>Titanium - chemistry</topic><topic>Titanium - pharmacology</topic><topic>Titanium dioxide nanoparticles</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ni, Min</creatorcontrib><creatorcontrib>Zhang, Hua</creatorcontrib><creatorcontrib>Li, Fan Chi</creatorcontrib><creatorcontrib>Wang, Bin Bin</creatorcontrib><creatorcontrib>Xu, Kai Zun</creatorcontrib><creatorcontrib>Shen, Wei De</creatorcontrib><creatorcontrib>Li, Bing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ni, Min</au><au>Zhang, Hua</au><au>Li, Fan Chi</au><au>Wang, Bin Bin</au><au>Xu, Kai Zun</au><au>Shen, Wei De</au><au>Li, Bing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nanoparticulate anatase TiO2 (TiO2 NPs) upregulates the expression of silkworm (Bombyx mori) neuropeptide receptor and promotes silkworm feeding, growth, and silking</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>68</volume><spage>64</spage><epage>71</epage><pages>64-71</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>•TiO2 NPs affect B. mori feeding and growth through increasing the expression of BmNPFR.•TiO2 NPs enhance BmNPFR binding to its ligands BmNPF1a and BmNPF1b.•BmNPFR is the primary and core target of TiO2 NPs’ promotion of B. mori growth and development.•TiO2 NPs have dose-dependent effects in different organs.
Bombyx mori orphan G protein-coupled receptor, BNGR-A4, is the specific receptor of B. mori neuropeptide F (BmNPFR, neuropeptide F designated NPF). BmNPFR binds specifically and efficiently to B. mori neuropeptides BmNPF1a and BmNPF1b, which activates the ERK1/2 signaling pathway to regulate B. mori food intake and growth. Titanium dioxide nanoparticles (TiO2 NPs) can promote B. mori growth. However, whether the mechanisms of TiO2 NPs’ effects are correlated with BmNPFR remains unknown. In this study, the effects of TiO2 NPs (5mg/L) feeding and BmNPFR-dsRNA injection on B. mori food intake and growth were investigated; after TiO2 NPs treatments, B. mori food intake, body weight, and cocoon shell weight were 5.82%, 4.64%, and 9.30% higher, respectively, than those of controls. The food intake, body weight, and cocoon shell weight of the BmNPFR-dsRNA injection group were reduced by 8.05%, 6.28%, and 6.98%, respectively, compared to the control. After TiO2 NPs treatment for 72h, the transcriptional levels of BmNPFR, BmNPF1a, and BmNPF1b in the midgut were 1.58, 1.43, and 1.34-folds, respectively, of those of the control, but 1.99, 2.26, and 2.19-folds, respectively, of the BmNPFR-dsRNA injection group; the phosphorylation level of MAPK was 24.03% higher than the control, while the phosphorylation level of BmNPFR-dsRNA injection group was 71.00% of control. The results indicated that TiO2 NPs affect B. mori feeding and growth through increasing the expression of BmNPFR. This study helps clarify the roles of BmNPF/BmNPFR system in TiO2 NPs’ effects on B. mori feeding, growth, and development.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25636404</pmid><doi>10.1016/j.peptides.2014.12.014</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 2015-06, Vol.68, p.64-71 |
| issn | 0196-9781 1873-5169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1681916495 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals BmNPFR Bombyx - drug effects Bombyx - physiology Bombyx mori Development Feeding Behavior Gene Expression Growth Insect Proteins - genetics Insect Proteins - metabolism Larva - drug effects Larva - physiology MAP Kinase Signaling System Nanoparticles - chemistry Particle Size Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Neuropeptide - genetics Receptors, Neuropeptide - metabolism Silk - biosynthesis Silking Titanium - chemistry Titanium - pharmacology Titanium dioxide nanoparticles Up-Regulation - drug effects |
| title | Nanoparticulate anatase TiO2 (TiO2 NPs) upregulates the expression of silkworm (Bombyx mori) neuropeptide receptor and promotes silkworm feeding, growth, and silking |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T07%3A31%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nanoparticulate%20anatase%20TiO2%20(TiO2%20NPs)%20upregulates%20the%20expression%20of%20silkworm%20(Bombyx%20mori)%20neuropeptide%20receptor%20and%20promotes%20silkworm%20feeding,%20growth,%20and%20silking&rft.jtitle=Peptides%20(New%20York,%20N.Y.%20:%201980)&rft.au=Ni,%20Min&rft.date=2015-06-01&rft.volume=68&rft.spage=64&rft.epage=71&rft.pages=64-71&rft.issn=0196-9781&rft.eissn=1873-5169&rft_id=info:doi/10.1016/j.peptides.2014.12.014&rft_dat=%3Cproquest_cross%3E1681916495%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1681916495&rft_id=info:pmid/25636404&rft_els_id=S0196978115000091&rfr_iscdi=true |