Gene expression patterns combined with network analysis identify hub genes associated with bladder cancer

[Display omitted] •We identified 332 global DEGs and DEGs in different stages and grades of BC.•Hub genes of complex networks were explored based on these DEGs.•UBE2C, ACTA2, FABP4, CKS2, FN1 and TOP2A were hub genes of networks.•ECM-receptor interaction and focal adhesion were the significant pathw...

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Veröffentlicht in:	Computational biology and chemistry 2015-06, Vol.56, p.71-83
Hauptverfasser:	Bi, Dongbin, Ning, Hao, Liu, Shuai, Que, Xinxiang, Ding, Kejia
Format:	Artikel
Sprache:	eng
Schlagworte:	Bayes Theorem Bioprocess Bladder cancer Co-expression network Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Ontology Gene Regulatory Networks Hub genes Humans Protein Interaction Maps Transcription Factors - genetics Transcription Factors - metabolism Urinary Bladder - metabolism Urinary Bladder - pathology Urinary Bladder Neoplasms - diagnosis Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism
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