The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans

Sirtuin 1 influences gene expression and other cellular functions through deacetylation of histone and nonhistone proteins. We here sought to determine the effects of a small molecule sirtuin 1 activator, SRT2104, on inflammation and coagulation induced by lipopolysaccharide in humans. A randomized,...

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Veröffentlicht in:	Critical care medicine 2015-06, Vol.43 (6), p.e199-e202
Hauptverfasser:	van der Meer, Anne J, Scicluna, Brendon P, Moerland, Perry D, Lin, Jiang, Jacobson, Eric W, Vlasuk, George P, van der Poll, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Coagulation - drug effects Cytokines - antagonists & inhibitors Double-Blind Method Endotoxins - metabolism Heterocyclic Compounds, 2-Ring - pharmacology Humans Lipopolysaccharides - pharmacology Male Sirtuin 1 - biosynthesis Young Adult
Online-Zugang:	Volltext
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