A conformation-based phage-display panning to screen neutralizing anti-VEGF VHHs with VEGFR2 mimicry behavior

The potency of VEGF-based anti-angiogenic strategies in cancer therapy and the brilliant characteristics of VHHs motivated us to directly block VEGF binding to its receptor with neutralizing single domain antibodies, thereby fading away the VEGF signaling pathway. Considering with high resolution cr...

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Veröffentlicht in:	International journal of biological macromolecules 2015-06, Vol.77, p.222-234
Hauptverfasser:	Shahangian, S. Shirin, H. Sajedi, Reza, Hasannia, Sadegh, Jalili, Shirin, Mohammadi, Mohammad, Taghdir, Majid, Shali, Abbas, Mansouri, Kamran, Sariri, Reyhaneh
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - immunology Antigen Presentation Binding Sites Human Umbilical Vein Endothelial Cells - immunology Human Umbilical Vein Endothelial Cells - metabolism Humans Immunization Immunoglobulin Heavy Chains - chemistry Immunoglobulin Heavy Chains - immunology Immunoglobulin Variable Region - chemistry Immunoglobulin Variable Region - immunology Molecular Docking Simulation Molecular Sequence Data Peptide Library Phage display Protein Structure, Secondary Protein Structure, Tertiary Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGF VHH
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