Management of apixaban-associated subdural hematoma: a case report on the use of factor eight inhibitor bypassing activity
We report a case of a patient receiving apixaban who developed a spontaneous subdural hematoma and declining mental status that improved after administration of a single dose of factor eight inhibitor bypassing activity. Case report. Comprehensive Stroke Center, Neurocritical Care Unit. A 76-year-ol...
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| Veröffentlicht in: | Critical care medicine 2015-06, Vol.43 (6), p.e203-e207 |
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| container_issue | 6 |
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| container_title | Critical care medicine |
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| creator | Rinehart, Derrick R Lockhart, Nicholas R Hamilton, Leslie A Langdon, J Russell Rowe, A Shaun |
| description | We report a case of a patient receiving apixaban who developed a spontaneous subdural hematoma and declining mental status that improved after administration of a single dose of factor eight inhibitor bypassing activity.
Case report.
Comprehensive Stroke Center, Neurocritical Care Unit.
A 76-year-old man presented to an outside facility with a chief complaint of headache and pain behind his right eye. A CT scan of his head revealed a subdural hematoma. The patient was transferred to our facility with worsening clinical status.
After a confirmatory cranial CT scan revealed a worsening subdural hematoma with midline shift, a single dose of factor VIII inhibitor bypassing activity (25 U/kg) was administered.
Coagulation tests following the administration of factor VIII inhibitor bypassing activity and a follow-up CT scan confirmed hemostasis. The patient was discharged home with no focal deficits.
Factor VIII inhibitor bypassing activity may be a viable, nonspecific reversal agent for life-threatening bleeding associated with apixaban. |
| doi_str_mv | 10.1097/CCM.0000000000000909 |
| format | Article |
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Case report.
Comprehensive Stroke Center, Neurocritical Care Unit.
A 76-year-old man presented to an outside facility with a chief complaint of headache and pain behind his right eye. A CT scan of his head revealed a subdural hematoma. The patient was transferred to our facility with worsening clinical status.
After a confirmatory cranial CT scan revealed a worsening subdural hematoma with midline shift, a single dose of factor VIII inhibitor bypassing activity (25 U/kg) was administered.
Coagulation tests following the administration of factor VIII inhibitor bypassing activity and a follow-up CT scan confirmed hemostasis. The patient was discharged home with no focal deficits.
Factor VIII inhibitor bypassing activity may be a viable, nonspecific reversal agent for life-threatening bleeding associated with apixaban.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/CCM.0000000000000909</identifier><identifier>PMID: 25738855</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Factor Xa Inhibitors - adverse effects ; Hematoma, Subdural - chemically induced ; Hematoma, Subdural - physiopathology ; Humans ; Male ; Pyrazoles - adverse effects ; Pyridones - adverse effects ; Tomography, X-Ray Computed</subject><ispartof>Critical care medicine, 2015-06, Vol.43 (6), p.e203-e207</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-ad27ef2196b520fff667e1b8136b100c3da9f61c23ecc30ad90d15c451ac454d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25738855$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rinehart, Derrick R</creatorcontrib><creatorcontrib>Lockhart, Nicholas R</creatorcontrib><creatorcontrib>Hamilton, Leslie A</creatorcontrib><creatorcontrib>Langdon, J Russell</creatorcontrib><creatorcontrib>Rowe, A Shaun</creatorcontrib><title>Management of apixaban-associated subdural hematoma: a case report on the use of factor eight inhibitor bypassing activity</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>We report a case of a patient receiving apixaban who developed a spontaneous subdural hematoma and declining mental status that improved after administration of a single dose of factor eight inhibitor bypassing activity.
Case report.
Comprehensive Stroke Center, Neurocritical Care Unit.
A 76-year-old man presented to an outside facility with a chief complaint of headache and pain behind his right eye. A CT scan of his head revealed a subdural hematoma. The patient was transferred to our facility with worsening clinical status.
After a confirmatory cranial CT scan revealed a worsening subdural hematoma with midline shift, a single dose of factor VIII inhibitor bypassing activity (25 U/kg) was administered.
Coagulation tests following the administration of factor VIII inhibitor bypassing activity and a follow-up CT scan confirmed hemostasis. The patient was discharged home with no focal deficits.
Factor VIII inhibitor bypassing activity may be a viable, nonspecific reversal agent for life-threatening bleeding associated with apixaban.</description><subject>Aged</subject><subject>Factor Xa Inhibitors - adverse effects</subject><subject>Hematoma, Subdural - chemically induced</subject><subject>Hematoma, Subdural - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Pyrazoles - adverse effects</subject><subject>Pyridones - adverse effects</subject><subject>Tomography, X-Ray Computed</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUMtOwzAQtBCIlsIfIOQjlxQ7jtOaG4p4Sa24wDnaOOvWqHlgO4jy9biiIMQedrSzO7PSEHLO2ZQzNbsqiuWU_S3F1AEZcylYwlIlDsl4xyUiU2JETrx_ZYxnciaOySiNMJ9LOSafS2hhhQ22gXaGQm8_oII2Ae87bSFgTf1Q1YODDV1jA6Fr4JoC1eCROuw7F3UtDWukQ2SihQEdOkfRrtaB2nZtK7ubq20fPW27onFv323YnpIjAxuPZ3uckJe72-fiIVk83T8WN4tEpzIPCdTpDE3KVV7JlBlj8nyGvJpzkVecMS1qUCbnOhWotWBQK1ZzqTPJIbasFhNy-e3bu-5tQB_KxnqNmw202A2-5PmcK864zONp9n2qXee9Q1P2zjbgtiVn5S71MqZe_k89yi72H4aqwfpX9BOz-AKPJX8O</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Rinehart, Derrick R</creator><creator>Lockhart, Nicholas R</creator><creator>Hamilton, Leslie A</creator><creator>Langdon, J Russell</creator><creator>Rowe, A Shaun</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150601</creationdate><title>Management of apixaban-associated subdural hematoma: a case report on the use of factor eight inhibitor bypassing activity</title><author>Rinehart, Derrick R ; Lockhart, Nicholas R ; Hamilton, Leslie A ; Langdon, J Russell ; Rowe, A Shaun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-ad27ef2196b520fff667e1b8136b100c3da9f61c23ecc30ad90d15c451ac454d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Factor Xa Inhibitors - adverse effects</topic><topic>Hematoma, Subdural - chemically induced</topic><topic>Hematoma, Subdural - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Pyrazoles - adverse effects</topic><topic>Pyridones - adverse effects</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rinehart, Derrick R</creatorcontrib><creatorcontrib>Lockhart, Nicholas R</creatorcontrib><creatorcontrib>Hamilton, Leslie A</creatorcontrib><creatorcontrib>Langdon, J Russell</creatorcontrib><creatorcontrib>Rowe, A Shaun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rinehart, Derrick R</au><au>Lockhart, Nicholas R</au><au>Hamilton, Leslie A</au><au>Langdon, J Russell</au><au>Rowe, A Shaun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of apixaban-associated subdural hematoma: a case report on the use of factor eight inhibitor bypassing activity</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>43</volume><issue>6</issue><spage>e203</spage><epage>e207</epage><pages>e203-e207</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><abstract>We report a case of a patient receiving apixaban who developed a spontaneous subdural hematoma and declining mental status that improved after administration of a single dose of factor eight inhibitor bypassing activity.
Case report.
Comprehensive Stroke Center, Neurocritical Care Unit.
A 76-year-old man presented to an outside facility with a chief complaint of headache and pain behind his right eye. A CT scan of his head revealed a subdural hematoma. The patient was transferred to our facility with worsening clinical status.
After a confirmatory cranial CT scan revealed a worsening subdural hematoma with midline shift, a single dose of factor VIII inhibitor bypassing activity (25 U/kg) was administered.
Coagulation tests following the administration of factor VIII inhibitor bypassing activity and a follow-up CT scan confirmed hemostasis. The patient was discharged home with no focal deficits.
Factor VIII inhibitor bypassing activity may be a viable, nonspecific reversal agent for life-threatening bleeding associated with apixaban.</abstract><cop>United States</cop><pmid>25738855</pmid><doi>10.1097/CCM.0000000000000909</doi></addata></record> |
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| ispartof | Critical care medicine, 2015-06, Vol.43 (6), p.e203-e207 |
| issn | 0090-3493 1530-0293 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aged Factor Xa Inhibitors - adverse effects Hematoma, Subdural - chemically induced Hematoma, Subdural - physiopathology Humans Male Pyrazoles - adverse effects Pyridones - adverse effects Tomography, X-Ray Computed |
| title | Management of apixaban-associated subdural hematoma: a case report on the use of factor eight inhibitor bypassing activity |
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