Short-term statin discontinuation increases endothelial progenitor cells without inflammatory rebound in type 2 diabetic patients

Abstract Type 2 diabetes (T2D) is characterized by impaired vascular regeneration owing to reduced endothelial progenitor cells (EPCs). While statins are known to increase EPCs, the effects of statin withdrawal on EPCs are unknown. Herein, we evaluated the effects of statin discontinuation on EPCs,...

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Veröffentlicht in:	Vascular pharmacology 2015-04, Vol.67, p.21-29
Hauptverfasser:	Fadini, Gian Paolo, Rigato, Mauro, Boscari, Federico, Cappellari, Roberta, Menegazzo, Lisa, Pilutti, Chiara, Iori, Elisabetta, Marescotti, Mariacristina, Plebani, Mario, Albiero, Mattia, Avogaro, Angelo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Angiogenesis Animals Cardiovascular Cells, Cultured Cholesterol, LDL - blood Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Drug Administration Schedule Endothelial Progenitor Cells - drug effects Endothelial Progenitor Cells - metabolism Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Inflammation - blood Inflammation - diagnosis Lipids Male Mice Mice, Knockout Middle Aged Regeneration Stem cells Therapy Time Factors
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