The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer

Abstract The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway plays a critical role in the malignant transformation of human tumors and their subsequent growth, proliferation, and metastasis. Preclinical investigations have suggested that the PI3K/AKT/mTOR pathwa...

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Veröffentlicht in:	Gynecologic oncology 2015-04, Vol.137 (1), p.173-179
Hauptverfasser:	Mabuchi, Seiji, Kuroda, Hiromasa, Takahashi, Ryoko, Sasano, Tomoyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT Animals Female Hematology, Oncology and Palliative Medicine Humans Molecular Targeted Therapy mTOR mTORC1 mTORC2 Obstetrics and Gynecology Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism PI3K Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
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