Mitochondrial pyruvate import and its effects on homeostasis

Highlights • Two inner membrane proteins compose the mitochondrial pyruvate carrier (MPC) complex. • Defects in MPC's activity perturb cellular and whole-body metabolic homeostasis. • The MPC is a promising target for curing diabetes, cancer, and other diseases.

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Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in cell biology 2015-04, Vol.33, p.35-41
Hauptverfasser:	Vanderperre, Benoît, Bender, Tom, Kunji, Edmund RS, Martinou, Jean-Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Glucose - metabolism Homeostasis Humans Internal Medicine Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mitochondria - metabolism Mitochondrial Membrane Transport Proteins Mitochondrial Membranes - metabolism Monocarboxylic Acid Transporters Mutation - genetics Neoplasms - metabolism Neoplasms - pathology Pyruvic Acid - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Two inner membrane proteins compose the mitochondrial pyruvate carrier (MPC) complex. • Defects in MPC's activity perturb cellular and whole-body metabolic homeostasis. • The MPC is a promising target for curing diabetes, cancer, and other diseases.
ISSN:	0955-0674 1879-0410
DOI:	10.1016/j.ceb.2014.10.008