Thr-422 and Tyr-424 Residues in the Carboxyl Terminus Are Critical for the Internalization of the Rat Neurotensin Receptor (∗)

In order to identify the amino acid sequences responsible for the internalization of the cloned rat brain neurotensin receptor, we carried out site-directed mutagenesis of the cDNA encoding the receptor followed by expression of the receptor into mammalian COS 7 cells. In cells transfected with the...

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Veröffentlicht in:	The Journal of biological chemistry 1995-02, Vol.270 (6), p.2439-2442
Hauptverfasser:	Chabry, Joëlle, Botto, Jean-Marie, Nouel, Dominique, Beaudet, Alain, Vincent, Jean-Pierre, Mazella, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological Transport Cell Line Cysteine - metabolism Microscopy, Confocal Molecular Sequence Data Mutagenesis, Site-Directed Rats Receptors, Neurotensin - genetics Receptors, Neurotensin - metabolism Threonine - metabolism Tyrosine - metabolism
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