Heparanase procoagulant activity, factor Xa, and plasminogen activator inhibitor 1 are increased in shift work female nurses
Epidemiologic studies indicate on an increased risk of cardiovascular disease and cancer in shift workers, although the underling mechanism is obscure. Heparanase directly enhances tissue factor (TF) activity leading to increased factor Xa production and subsequent activation of the coagulation syst...
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Veröffentlicht in: | Annals of hematology 2015-07, Vol.94 (7), p.1213-1219 |
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creator | Nadir, Yona Saharov, Gleb Hoffman, Ron Keren-Politansky, Anat Tzoran, Inna Brenner, Benjamin Shochat, Tamar |
description | Epidemiologic studies indicate on an increased risk of cardiovascular disease and cancer in shift workers, although the underling mechanism is obscure. Heparanase directly enhances tissue factor (TF) activity leading to increased factor Xa production and subsequent activation of the coagulation system. In the present study, a comparison of coagulation markers among healthy shift working (SW) vs. healthy daytime working (DW) female nurses was performed. Thirty SW and 30 DW female nurses were enrolled. For each of the 60 participants, blood was drawn between 7:00 and 8:00 a.m. and at least 8 h after the last work shift. Plasma was studied for coagulation marker that included TF/heparanase procoagulant activity, TF activity, heparanase procoagulant activity, heparanase level, factor Xa level, plasminogen activator inhibitor 1 (PAI-1), plasminogen, α
2
-antiplasmin, fibrinogen, global protein C, von Willebrand factor, and D-dimer by chromogenic assays and enzyme-linked immunosorbent assays (ELISAs). Sleep quality was assessed by self-report according to the Pittsburgh Sleep Quality Index. The heparanase procoagulant activity increased by 2-fold and the TF/heparanase procoagulant activity increased by 1.5-fold in SW nurses compared to DW nurses (
P
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doi_str_mv | 10.1007/s00277-015-2345-8 |
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2
-antiplasmin, fibrinogen, global protein C, von Willebrand factor, and D-dimer by chromogenic assays and enzyme-linked immunosorbent assays (ELISAs). Sleep quality was assessed by self-report according to the Pittsburgh Sleep Quality Index. The heparanase procoagulant activity increased by 2-fold and the TF/heparanase procoagulant activity increased by 1.5-fold in SW nurses compared to DW nurses (
P
< 0.05). Factor Xa levels and PAI-1 levels were significantly higher among SW nurses compared to the DW group (22 vs. 18 ng/ml,
P
< 0.05, and 32 vs. 22 ng/ml,
P
< 0.005, respectively). No significant differences were found in the other tested coagulation markers between the study groups. Heparanase procoagulant activity, factor Xa level, and PAI-1 level were significantly higher in SW nurses compared to the DW group. These alterations of blood coagulation activation may potentially contribute to cardiovascular and cancer morbidity.</description><identifier>ISSN: 0939-5555</identifier><identifier>EISSN: 1432-0584</identifier><identifier>DOI: 10.1007/s00277-015-2345-8</identifier><identifier>PMID: 25743687</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Blood Coagulation - physiology ; Factor Xa - metabolism ; Female ; Glucuronidase - blood ; Hematology ; Humans ; Medicine ; Medicine & Public Health ; Nurses ; Oncology ; Original Article ; Plasminogen Activator Inhibitor 1 - blood ; Self Report ; Work Schedule Tolerance - physiology</subject><ispartof>Annals of hematology, 2015-07, Vol.94 (7), p.1213-1219</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-3b1c743068b4b08e92ed80f8f7b70033ff0bae9d798dcaffb2f2fc76b4589f763</citedby><cites>FETCH-LOGICAL-c372t-3b1c743068b4b08e92ed80f8f7b70033ff0bae9d798dcaffb2f2fc76b4589f763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00277-015-2345-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00277-015-2345-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25743687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nadir, Yona</creatorcontrib><creatorcontrib>Saharov, Gleb</creatorcontrib><creatorcontrib>Hoffman, Ron</creatorcontrib><creatorcontrib>Keren-Politansky, Anat</creatorcontrib><creatorcontrib>Tzoran, Inna</creatorcontrib><creatorcontrib>Brenner, Benjamin</creatorcontrib><creatorcontrib>Shochat, Tamar</creatorcontrib><title>Heparanase procoagulant activity, factor Xa, and plasminogen activator inhibitor 1 are increased in shift work female nurses</title><title>Annals of hematology</title><addtitle>Ann Hematol</addtitle><addtitle>Ann Hematol</addtitle><description>Epidemiologic studies indicate on an increased risk of cardiovascular disease and cancer in shift workers, although the underling mechanism is obscure. Heparanase directly enhances tissue factor (TF) activity leading to increased factor Xa production and subsequent activation of the coagulation system. In the present study, a comparison of coagulation markers among healthy shift working (SW) vs. healthy daytime working (DW) female nurses was performed. Thirty SW and 30 DW female nurses were enrolled. For each of the 60 participants, blood was drawn between 7:00 and 8:00 a.m. and at least 8 h after the last work shift. Plasma was studied for coagulation marker that included TF/heparanase procoagulant activity, TF activity, heparanase procoagulant activity, heparanase level, factor Xa level, plasminogen activator inhibitor 1 (PAI-1), plasminogen, α
2
-antiplasmin, fibrinogen, global protein C, von Willebrand factor, and D-dimer by chromogenic assays and enzyme-linked immunosorbent assays (ELISAs). Sleep quality was assessed by self-report according to the Pittsburgh Sleep Quality Index. The heparanase procoagulant activity increased by 2-fold and the TF/heparanase procoagulant activity increased by 1.5-fold in SW nurses compared to DW nurses (
P
< 0.05). Factor Xa levels and PAI-1 levels were significantly higher among SW nurses compared to the DW group (22 vs. 18 ng/ml,
P
< 0.05, and 32 vs. 22 ng/ml,
P
< 0.005, respectively). No significant differences were found in the other tested coagulation markers between the study groups. Heparanase procoagulant activity, factor Xa level, and PAI-1 level were significantly higher in SW nurses compared to the DW group. These alterations of blood coagulation activation may potentially contribute to cardiovascular and cancer morbidity.</description><subject>Adult</subject><subject>Blood Coagulation - physiology</subject><subject>Factor Xa - metabolism</subject><subject>Female</subject><subject>Glucuronidase - blood</subject><subject>Hematology</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nurses</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>Self Report</subject><subject>Work Schedule Tolerance - physiology</subject><issn>0939-5555</issn><issn>1432-0584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUFrFTEUhYMo9rX6A9xIwI2LTnuTzEwySylqhYIbC-5Ckrl5TZ3JPJOZSsEf3wxTiwhmkxPud0_u5RDyhsEZA5DnGYBLWQFrKi7qplLPyI7VglfQqPo52UEnuqop54gc53wLwLiq-UtyxBtZi1bJHfl9iQeTTDQZ6SFNbjL7ZTBxpsbN4S7M96fUFzkl-t2cUhN7ehhMHkOc9hg3yKzVEG-CDati1CQsb5ewmPZF0XwT_Ex_TekH9TiaAWlcUsb8irzwZsj4-vE-IdefPn67uKyuvn7-cvHhqnJC8rkSlrkyL7TK1hYUdhx7BV55aSWAEN6DNdj1slO9M95b7rl3srV1ozovW3FC3m--ZcOfC-ZZjyE7HMqiOC1Zs1Yx3rZd1xT03T_o7bSkWKZbKehY2whVKLZRLk05J_T6kMJo0r1moNdo9BaNLtHoNRq99rx9dF7siP1Tx58sCsA3IJdS3GP66-v_uj4AHQya0w</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Nadir, Yona</creator><creator>Saharov, Gleb</creator><creator>Hoffman, Ron</creator><creator>Keren-Politansky, Anat</creator><creator>Tzoran, Inna</creator><creator>Brenner, Benjamin</creator><creator>Shochat, Tamar</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150701</creationdate><title>Heparanase procoagulant activity, factor Xa, and plasminogen activator inhibitor 1 are increased in shift work female nurses</title><author>Nadir, Yona ; Saharov, Gleb ; Hoffman, Ron ; Keren-Politansky, Anat ; Tzoran, Inna ; Brenner, Benjamin ; Shochat, Tamar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-3b1c743068b4b08e92ed80f8f7b70033ff0bae9d798dcaffb2f2fc76b4589f763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Blood Coagulation - physiology</topic><topic>Factor Xa - metabolism</topic><topic>Female</topic><topic>Glucuronidase - blood</topic><topic>Hematology</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nurses</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Plasminogen Activator Inhibitor 1 - blood</topic><topic>Self Report</topic><topic>Work Schedule Tolerance - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nadir, Yona</creatorcontrib><creatorcontrib>Saharov, Gleb</creatorcontrib><creatorcontrib>Hoffman, Ron</creatorcontrib><creatorcontrib>Keren-Politansky, Anat</creatorcontrib><creatorcontrib>Tzoran, Inna</creatorcontrib><creatorcontrib>Brenner, Benjamin</creatorcontrib><creatorcontrib>Shochat, Tamar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nadir, Yona</au><au>Saharov, Gleb</au><au>Hoffman, Ron</au><au>Keren-Politansky, Anat</au><au>Tzoran, Inna</au><au>Brenner, Benjamin</au><au>Shochat, Tamar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heparanase procoagulant activity, factor Xa, and plasminogen activator inhibitor 1 are increased in shift work female nurses</atitle><jtitle>Annals of hematology</jtitle><stitle>Ann Hematol</stitle><addtitle>Ann Hematol</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>94</volume><issue>7</issue><spage>1213</spage><epage>1219</epage><pages>1213-1219</pages><issn>0939-5555</issn><eissn>1432-0584</eissn><abstract>Epidemiologic studies indicate on an increased risk of cardiovascular disease and cancer in shift workers, although the underling mechanism is obscure. Heparanase directly enhances tissue factor (TF) activity leading to increased factor Xa production and subsequent activation of the coagulation system. In the present study, a comparison of coagulation markers among healthy shift working (SW) vs. healthy daytime working (DW) female nurses was performed. Thirty SW and 30 DW female nurses were enrolled. For each of the 60 participants, blood was drawn between 7:00 and 8:00 a.m. and at least 8 h after the last work shift. Plasma was studied for coagulation marker that included TF/heparanase procoagulant activity, TF activity, heparanase procoagulant activity, heparanase level, factor Xa level, plasminogen activator inhibitor 1 (PAI-1), plasminogen, α
2
-antiplasmin, fibrinogen, global protein C, von Willebrand factor, and D-dimer by chromogenic assays and enzyme-linked immunosorbent assays (ELISAs). Sleep quality was assessed by self-report according to the Pittsburgh Sleep Quality Index. The heparanase procoagulant activity increased by 2-fold and the TF/heparanase procoagulant activity increased by 1.5-fold in SW nurses compared to DW nurses (
P
< 0.05). Factor Xa levels and PAI-1 levels were significantly higher among SW nurses compared to the DW group (22 vs. 18 ng/ml,
P
< 0.05, and 32 vs. 22 ng/ml,
P
< 0.005, respectively). No significant differences were found in the other tested coagulation markers between the study groups. Heparanase procoagulant activity, factor Xa level, and PAI-1 level were significantly higher in SW nurses compared to the DW group. These alterations of blood coagulation activation may potentially contribute to cardiovascular and cancer morbidity.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25743687</pmid><doi>10.1007/s00277-015-2345-8</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Blood Coagulation - physiology Factor Xa - metabolism Female Glucuronidase - blood Hematology Humans Medicine Medicine & Public Health Nurses Oncology Original Article Plasminogen Activator Inhibitor 1 - blood Self Report Work Schedule Tolerance - physiology |
title | Heparanase procoagulant activity, factor Xa, and plasminogen activator inhibitor 1 are increased in shift work female nurses |
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