Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease

Abstract Cerebrospinal fluid YKL-40 has been described as a marker of glial inflammation. We aimed to study the relationship between YKL-40 and brain structure and its interactions with core Alzheimer's disease (AD) biomarkers. We measured cortical thickness (CTh) and cerebrospinal fluid biomar...

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Veröffentlicht in:	Neurobiology of aging 2015-06, Vol.36 (6), p.2018-2023
Hauptverfasser:	Alcolea, Daniel, Vilaplana, Eduard, Pegueroles, Jordi, Montal, Victor, Sánchez-Juan, Pascual, González-Suárez, Andrea, Pozueta, Ana, Rodríguez-Rodríguez, Eloy, Bartrés-Faz, David, Vidal-Piñeiro, Dídac, González-Ortiz, Sofía, Medrano, Santiago, Carmona-Iragui, María, Sánchez-Saudinós, M Belén, Sala, Isabel, Anton-Aguirre, Sofía, Sampedro, Frederic, Morenas-Rodríguez, Estrella, Clarimón, Jordi, Blesa, Rafael, Lleó, Alberto, Fortea, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipokines - cerebrospinal fluid Aged Alzheimer Disease - diagnosis Alzheimer Disease - pathology Atrophy Biomarkers - cerebrospinal fluid Cerebral Cortex - pathology Chitinase-3-Like Protein 1 Cognitive Dysfunction - diagnosis Cognitive Dysfunction - pathology Cortical thickness CSF biomarkers Female Humans Inflammation Internal Medicine Lectins - cerebrospinal fluid Magnetic Resonance Imaging Male Middle Aged Neuroinflammation Neurology Preclinical Alzheimer's disease Structural MRI tau Proteins - cerebrospinal fluid YKL-40
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