Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease
Abstract Cerebrospinal fluid YKL-40 has been described as a marker of glial inflammation. We aimed to study the relationship between YKL-40 and brain structure and its interactions with core Alzheimer's disease (AD) biomarkers. We measured cortical thickness (CTh) and cerebrospinal fluid biomar...
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| Veröffentlicht in: | Neurobiology of aging 2015-06, Vol.36 (6), p.2018-2023 |
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| creator | Alcolea, Daniel Vilaplana, Eduard Pegueroles, Jordi Montal, Victor Sánchez-Juan, Pascual González-Suárez, Andrea Pozueta, Ana Rodríguez-Rodríguez, Eloy Bartrés-Faz, David Vidal-Piñeiro, Dídac González-Ortiz, Sofía Medrano, Santiago Carmona-Iragui, María Sánchez-Saudinós, M Belén Sala, Isabel Anton-Aguirre, Sofía Sampedro, Frederic Morenas-Rodríguez, Estrella Clarimón, Jordi Blesa, Rafael Lleó, Alberto Fortea, Juan |
| description | Abstract Cerebrospinal fluid YKL-40 has been described as a marker of glial inflammation. We aimed to study the relationship between YKL-40 and brain structure and its interactions with core Alzheimer's disease (AD) biomarkers. We measured cortical thickness (CTh) and cerebrospinal fluid biomarkers (amyloid-β 1–42 [Aβ42], total tau, p-tau, and YKL-40) of 80 cognitively normal controls and 27 patients with amnestic mild cognitive impairment. Subjects were classified as Aβ42+ (550 pg/mL). CTh difference maps were derived from the interaction and correlation analyses in the whole sample and within clinical groups. There was a strong correlation between YKL-40 and markers of neurodegeneration (total tau and p-tau). In the whole sample, we found a negative correlation between YKL-40 and CTh in AD vulnerable areas in Aβ42+ subjects but not in Aβ42 participants. Our results suggest that YKL-40 could track the inflammatory processes associated to tau-related neurodegeneration in the presence of the AD pathophysiological process. |
| doi_str_mv | 10.1016/j.neurobiolaging.2015.03.001 |
| format | Article |
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We aimed to study the relationship between YKL-40 and brain structure and its interactions with core Alzheimer's disease (AD) biomarkers. We measured cortical thickness (CTh) and cerebrospinal fluid biomarkers (amyloid-β 1–42 [Aβ42], total tau, p-tau, and YKL-40) of 80 cognitively normal controls and 27 patients with amnestic mild cognitive impairment. Subjects were classified as Aβ42+ (<550 pg/mL) or Aβ42− (>550 pg/mL). CTh difference maps were derived from the interaction and correlation analyses in the whole sample and within clinical groups. There was a strong correlation between YKL-40 and markers of neurodegeneration (total tau and p-tau). In the whole sample, we found a negative correlation between YKL-40 and CTh in AD vulnerable areas in Aβ42+ subjects but not in Aβ42 participants. Our results suggest that YKL-40 could track the inflammatory processes associated to tau-related neurodegeneration in the presence of the AD pathophysiological process.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2015.03.001</identifier><identifier>PMID: 25865441</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adipokines - cerebrospinal fluid ; Aged ; Alzheimer Disease - diagnosis ; Alzheimer Disease - pathology ; Atrophy ; Biomarkers - cerebrospinal fluid ; Cerebral Cortex - pathology ; Chitinase-3-Like Protein 1 ; Cognitive Dysfunction - diagnosis ; Cognitive Dysfunction - pathology ; Cortical thickness ; CSF biomarkers ; Female ; Humans ; Inflammation ; Internal Medicine ; Lectins - cerebrospinal fluid ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuroinflammation ; Neurology ; Preclinical Alzheimer's disease ; Structural MRI ; tau Proteins - cerebrospinal fluid ; YKL-40</subject><ispartof>Neurobiology of aging, 2015-06, Vol.36 (6), p.2018-2023</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-cfa83706cedd7f65c6fc9cdc20cd24653020135ba5bc3a32aee85b696afda2973</citedby><cites>FETCH-LOGICAL-c511t-cfa83706cedd7f65c6fc9cdc20cd24653020135ba5bc3a32aee85b696afda2973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0197458015001621$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25865441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alcolea, Daniel</creatorcontrib><creatorcontrib>Vilaplana, Eduard</creatorcontrib><creatorcontrib>Pegueroles, Jordi</creatorcontrib><creatorcontrib>Montal, Victor</creatorcontrib><creatorcontrib>Sánchez-Juan, Pascual</creatorcontrib><creatorcontrib>González-Suárez, Andrea</creatorcontrib><creatorcontrib>Pozueta, Ana</creatorcontrib><creatorcontrib>Rodríguez-Rodríguez, Eloy</creatorcontrib><creatorcontrib>Bartrés-Faz, David</creatorcontrib><creatorcontrib>Vidal-Piñeiro, Dídac</creatorcontrib><creatorcontrib>González-Ortiz, Sofía</creatorcontrib><creatorcontrib>Medrano, Santiago</creatorcontrib><creatorcontrib>Carmona-Iragui, María</creatorcontrib><creatorcontrib>Sánchez-Saudinós, M Belén</creatorcontrib><creatorcontrib>Sala, Isabel</creatorcontrib><creatorcontrib>Anton-Aguirre, Sofía</creatorcontrib><creatorcontrib>Sampedro, Frederic</creatorcontrib><creatorcontrib>Morenas-Rodríguez, Estrella</creatorcontrib><creatorcontrib>Clarimón, Jordi</creatorcontrib><creatorcontrib>Blesa, Rafael</creatorcontrib><creatorcontrib>Lleó, Alberto</creatorcontrib><creatorcontrib>Fortea, Juan</creatorcontrib><title>Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract Cerebrospinal fluid YKL-40 has been described as a marker of glial inflammation. We aimed to study the relationship between YKL-40 and brain structure and its interactions with core Alzheimer's disease (AD) biomarkers. We measured cortical thickness (CTh) and cerebrospinal fluid biomarkers (amyloid-β 1–42 [Aβ42], total tau, p-tau, and YKL-40) of 80 cognitively normal controls and 27 patients with amnestic mild cognitive impairment. Subjects were classified as Aβ42+ (<550 pg/mL) or Aβ42− (>550 pg/mL). CTh difference maps were derived from the interaction and correlation analyses in the whole sample and within clinical groups. There was a strong correlation between YKL-40 and markers of neurodegeneration (total tau and p-tau). In the whole sample, we found a negative correlation between YKL-40 and CTh in AD vulnerable areas in Aβ42+ subjects but not in Aβ42 participants. Our results suggest that YKL-40 could track the inflammatory processes associated to tau-related neurodegeneration in the presence of the AD pathophysiological process.</description><subject>Adipokines - cerebrospinal fluid</subject><subject>Aged</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - pathology</subject><subject>Atrophy</subject><subject>Biomarkers - cerebrospinal fluid</subject><subject>Cerebral Cortex - pathology</subject><subject>Chitinase-3-Like Protein 1</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive Dysfunction - pathology</subject><subject>Cortical thickness</subject><subject>CSF biomarkers</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Lectins - cerebrospinal fluid</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuroinflammation</subject><subject>Neurology</subject><subject>Preclinical Alzheimer's disease</subject><subject>Structural MRI</subject><subject>tau Proteins - cerebrospinal fluid</subject><subject>YKL-40</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk-LFDEQxYMo7rj6FSQHQS_dJulOuhtEWBZXxQHBPwdPIZ1Uz2S2O5lNdSvrpzfNrIKePNWh3qvi96oIecZZyRlXLw9lgCXF3sfR7HzYlYJxWbKqZIzfIxsuZVvwumvukw3jXVPUsmVn5BHigTHW1I16SM6EbJWsa74h-AlGM_sYcO-PtIf5B0CgNqbZWzPSee_tdQBEaoKjFhL0KeLRh9wbxsU7-u3DtqgZ9YEeEziYIMzeUJzNDpDGgV6MP_fgJ0jPkTqPYBAekweDGRGe3NVz8vXqzZfLd8X249v3lxfbwkrO58IOpq0apiw41wxKWjXYzjormHWiVrJimbySvZG9rUwlDEAre9UpMzgjuqY6Jy9Oc48p3iyAs548WhhHEyAuqLlquVBKCJalr05Sm_EwwaCPyU8m3WrO9Bq7Pui_Y9dr7JpVOsee7U_vNi39BO6P-XfOWXB1EkDm_e4habQeQkbzCeysXfT_u-n1P4Ps6MN6q2u4BTzEJeXbZDaNQjP9eX2B9QO4zG4lePULQQezkw</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Alcolea, Daniel</creator><creator>Vilaplana, Eduard</creator><creator>Pegueroles, Jordi</creator><creator>Montal, Victor</creator><creator>Sánchez-Juan, Pascual</creator><creator>González-Suárez, Andrea</creator><creator>Pozueta, Ana</creator><creator>Rodríguez-Rodríguez, Eloy</creator><creator>Bartrés-Faz, David</creator><creator>Vidal-Piñeiro, Dídac</creator><creator>González-Ortiz, Sofía</creator><creator>Medrano, Santiago</creator><creator>Carmona-Iragui, María</creator><creator>Sánchez-Saudinós, M Belén</creator><creator>Sala, Isabel</creator><creator>Anton-Aguirre, Sofía</creator><creator>Sampedro, Frederic</creator><creator>Morenas-Rodríguez, Estrella</creator><creator>Clarimón, Jordi</creator><creator>Blesa, Rafael</creator><creator>Lleó, Alberto</creator><creator>Fortea, Juan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150601</creationdate><title>Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease</title><author>Alcolea, Daniel ; Vilaplana, Eduard ; Pegueroles, Jordi ; Montal, Victor ; Sánchez-Juan, Pascual ; González-Suárez, Andrea ; Pozueta, Ana ; Rodríguez-Rodríguez, Eloy ; Bartrés-Faz, David ; Vidal-Piñeiro, Dídac ; González-Ortiz, Sofía ; Medrano, Santiago ; Carmona-Iragui, María ; Sánchez-Saudinós, M Belén ; Sala, Isabel ; Anton-Aguirre, Sofía ; Sampedro, Frederic ; Morenas-Rodríguez, Estrella ; Clarimón, Jordi ; Blesa, Rafael ; Lleó, Alberto ; Fortea, Juan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-cfa83706cedd7f65c6fc9cdc20cd24653020135ba5bc3a32aee85b696afda2973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adipokines - cerebrospinal fluid</topic><topic>Aged</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - pathology</topic><topic>Atrophy</topic><topic>Biomarkers - cerebrospinal fluid</topic><topic>Cerebral Cortex - pathology</topic><topic>Chitinase-3-Like Protein 1</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Cognitive Dysfunction - pathology</topic><topic>Cortical thickness</topic><topic>CSF biomarkers</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>Lectins - cerebrospinal fluid</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuroinflammation</topic><topic>Neurology</topic><topic>Preclinical Alzheimer's disease</topic><topic>Structural MRI</topic><topic>tau Proteins - cerebrospinal fluid</topic><topic>YKL-40</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alcolea, Daniel</creatorcontrib><creatorcontrib>Vilaplana, Eduard</creatorcontrib><creatorcontrib>Pegueroles, Jordi</creatorcontrib><creatorcontrib>Montal, Victor</creatorcontrib><creatorcontrib>Sánchez-Juan, Pascual</creatorcontrib><creatorcontrib>González-Suárez, Andrea</creatorcontrib><creatorcontrib>Pozueta, Ana</creatorcontrib><creatorcontrib>Rodríguez-Rodríguez, Eloy</creatorcontrib><creatorcontrib>Bartrés-Faz, David</creatorcontrib><creatorcontrib>Vidal-Piñeiro, Dídac</creatorcontrib><creatorcontrib>González-Ortiz, Sofía</creatorcontrib><creatorcontrib>Medrano, Santiago</creatorcontrib><creatorcontrib>Carmona-Iragui, María</creatorcontrib><creatorcontrib>Sánchez-Saudinós, M Belén</creatorcontrib><creatorcontrib>Sala, Isabel</creatorcontrib><creatorcontrib>Anton-Aguirre, Sofía</creatorcontrib><creatorcontrib>Sampedro, Frederic</creatorcontrib><creatorcontrib>Morenas-Rodríguez, Estrella</creatorcontrib><creatorcontrib>Clarimón, Jordi</creatorcontrib><creatorcontrib>Blesa, Rafael</creatorcontrib><creatorcontrib>Lleó, Alberto</creatorcontrib><creatorcontrib>Fortea, Juan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alcolea, Daniel</au><au>Vilaplana, Eduard</au><au>Pegueroles, Jordi</au><au>Montal, Victor</au><au>Sánchez-Juan, Pascual</au><au>González-Suárez, Andrea</au><au>Pozueta, Ana</au><au>Rodríguez-Rodríguez, Eloy</au><au>Bartrés-Faz, David</au><au>Vidal-Piñeiro, Dídac</au><au>González-Ortiz, Sofía</au><au>Medrano, Santiago</au><au>Carmona-Iragui, María</au><au>Sánchez-Saudinós, M Belén</au><au>Sala, Isabel</au><au>Anton-Aguirre, Sofía</au><au>Sampedro, Frederic</au><au>Morenas-Rodríguez, Estrella</au><au>Clarimón, Jordi</au><au>Blesa, Rafael</au><au>Lleó, Alberto</au><au>Fortea, Juan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>36</volume><issue>6</issue><spage>2018</spage><epage>2023</epage><pages>2018-2023</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>Abstract Cerebrospinal fluid YKL-40 has been described as a marker of glial inflammation. We aimed to study the relationship between YKL-40 and brain structure and its interactions with core Alzheimer's disease (AD) biomarkers. We measured cortical thickness (CTh) and cerebrospinal fluid biomarkers (amyloid-β 1–42 [Aβ42], total tau, p-tau, and YKL-40) of 80 cognitively normal controls and 27 patients with amnestic mild cognitive impairment. Subjects were classified as Aβ42+ (<550 pg/mL) or Aβ42− (>550 pg/mL). CTh difference maps were derived from the interaction and correlation analyses in the whole sample and within clinical groups. There was a strong correlation between YKL-40 and markers of neurodegeneration (total tau and p-tau). In the whole sample, we found a negative correlation between YKL-40 and CTh in AD vulnerable areas in Aβ42+ subjects but not in Aβ42 participants. Our results suggest that YKL-40 could track the inflammatory processes associated to tau-related neurodegeneration in the presence of the AD pathophysiological process.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25865441</pmid><doi>10.1016/j.neurobiolaging.2015.03.001</doi><tpages>6</tpages></addata></record> |
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| subjects | Adipokines - cerebrospinal fluid Aged Alzheimer Disease - diagnosis Alzheimer Disease - pathology Atrophy Biomarkers - cerebrospinal fluid Cerebral Cortex - pathology Chitinase-3-Like Protein 1 Cognitive Dysfunction - diagnosis Cognitive Dysfunction - pathology Cortical thickness CSF biomarkers Female Humans Inflammation Internal Medicine Lectins - cerebrospinal fluid Magnetic Resonance Imaging Male Middle Aged Neuroinflammation Neurology Preclinical Alzheimer's disease Structural MRI tau Proteins - cerebrospinal fluid YKL-40 |
| title | Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease |
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