Modular Synthesis of Constrained Ethyl (cEt) Purine and Pyrimidine Nucleosides

A modular and scalable approach to pyrimidine- and purine-containing constrained ethyl (cEt) nucleosides is demonstrated. Minimizing stereochemical adjustments and protecting group manipulations, diacetone glucose is converted to two representative cEt nucleosides via a functionalized, common interm...

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Veröffentlicht in:	Journal of organic chemistry 2015-05, Vol.80 (10), p.5337-5343
Hauptverfasser:	Blade, Helen, Bradley, Derek, Diorazio, Louis, Evans, Timothy, Hayter, Barry R, Howell, Gareth P
Format:	Artikel
Sprache:	eng
Schlagworte:	Molecular Structure Nucleosides - chemical synthesis Nucleosides - chemistry Prodrugs - chemical synthesis Prodrugs - chemistry Purine Nucleosides - chemical synthesis Purine Nucleosides - chemistry Pyrimidine Nucleosides - chemical synthesis Pyrimidine Nucleosides - chemistry
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