Total Synthesis of Proanthocyanidin A1, A2, and Their Stereoisomers

The first novel stereoselective synthesis of naturally occurring A1 (1) and A2 proanthocyanidins (2) has been achieved. The key synthetic steps involved (a) the formation of a coupled product (13 or 14) between an open chain C-ring C-4 hydroxyethoxy analogue of either (+)-catechin or (−)-epicatechin...

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Veröffentlicht in:	Organic letters 2015-05, Vol.17 (10), p.2306-2309
Hauptverfasser:	Sharma, Pradeep K, Romanczyk, Leo J, Kondaveti, Leelakrishna, Reddy, Bollu, Arumugasamy, Jeeva, Lombardy, Richard, Gou, Yanni, Schroeter, Hagen
Format:	Artikel
Sprache:	eng
Schlagworte:	Catechin - chemistry Molecular Structure Proanthocyanidins - chemical synthesis Proanthocyanidins - chemistry Stereoisomerism
Online-Zugang:	Volltext
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