Cytoflavin® effect on endothelium function and cerebral hemodynamics in patients with hypertensive enceplalopathy
One hundred forty patients (the average age of 46.7 ± 7.7 years) with hypertensive encephalopathy (HE) were observed. 74 patients of the main group received Cytoflavin in a dose of 2 tablets twise a day in the standard basic therapy. 66 patients of the reference group received the basic therapy alon...
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| Veröffentlicht in: | Antibiotiki i himioterapiâ 2014, Vol.59 (7-8), p.30-36 |
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| creator | Belova, L A Mashin, V V Kolotik-Kameneva, O Yu Proshin, A N |
| description | One hundred forty patients (the average age of 46.7 ± 7.7 years) with hypertensive encephalopathy (HE) were observed. 74 patients of the main group received Cytoflavin in a dose of 2 tablets twise a day in the standard basic therapy. 66 patients of the reference group received the basic therapy alone. The arterial endothelium function was estimated and ultrasonic examination of the hemodynamics at five structurally functional levels of the cerebral vascular course was used. All the patients with HE had endothelial dysfunction, bloodstream depression in the arterial course of the brain vascular system, decreased reactivity of the intracranial veins, difficulty in venous outflow. In the course of the therapy with Cytoflavin restotation of the arterial endothelial function in the patients with HE I stage, the linear and volume speed of bloodstream in the main and intracranial cerebral arteries in the patients with HE I-II stages, restoration of the intracranial veins reactivity, the linear speed of bloodstream in intracranial veins in the patients with all three stages of HE, the linear speed of bloodstream in the main veins up to the control values in the patients with I-III stages of HE were observed. Interrelation between the values of the cerebral hemodynamics and the state of the endothelium function was shown. |
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The arterial endothelium function was estimated and ultrasonic examination of the hemodynamics at five structurally functional levels of the cerebral vascular course was used. All the patients with HE had endothelial dysfunction, bloodstream depression in the arterial course of the brain vascular system, decreased reactivity of the intracranial veins, difficulty in venous outflow. In the course of the therapy with Cytoflavin restotation of the arterial endothelial function in the patients with HE I stage, the linear and volume speed of bloodstream in the main and intracranial cerebral arteries in the patients with HE I-II stages, restoration of the intracranial veins reactivity, the linear speed of bloodstream in intracranial veins in the patients with all three stages of HE, the linear speed of bloodstream in the main veins up to the control values in the patients with I-III stages of HE were observed. 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The arterial endothelium function was estimated and ultrasonic examination of the hemodynamics at five structurally functional levels of the cerebral vascular course was used. All the patients with HE had endothelial dysfunction, bloodstream depression in the arterial course of the brain vascular system, decreased reactivity of the intracranial veins, difficulty in venous outflow. In the course of the therapy with Cytoflavin restotation of the arterial endothelial function in the patients with HE I stage, the linear and volume speed of bloodstream in the main and intracranial cerebral arteries in the patients with HE I-II stages, restoration of the intracranial veins reactivity, the linear speed of bloodstream in intracranial veins in the patients with all three stages of HE, the linear speed of bloodstream in the main veins up to the control values in the patients with I-III stages of HE were observed. Interrelation between the values of the cerebral hemodynamics and the state of the endothelium function was shown.</description><subject>Adult</subject><subject>Aged</subject><subject>Brain - blood supply</subject><subject>Brain - drug effects</subject><subject>Brain - pathology</subject><subject>Cerebral Arteries - diagnostic imaging</subject><subject>Cerebral Arteries - drug effects</subject><subject>Cerebral Arteries - pathology</subject><subject>Drug Administration Schedule</subject><subject>Drug Combinations</subject><subject>Endothelium, Vascular - diagnostic imaging</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - pathology</subject><subject>Female</subject><subject>Flavin Mononucleotide - pharmacology</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Hypertensive Encephalopathy - diagnostic imaging</subject><subject>Hypertensive Encephalopathy - drug therapy</subject><subject>Hypertensive Encephalopathy - pathology</subject><subject>Inosine Diphosphate - pharmacology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Niacinamide - pharmacology</subject><subject>Succinates - pharmacology</subject><subject>Ultrasonography</subject><issn>0235-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kL1qwzAYRTW0NCHNKxSNXQySZUn2WEL_IJAlu5HlT1hFllxJTvFL9SH6ZDU0nS4cDme4N2hLSsaLsmnIBu1T-iCEMEYZI-QObUreSE4J36J4WHIwTl2s__nGYAzojIPH4PuQB3B2HrGZvc52hcr3WEOELiqHBxhDv3g1Wp2w9XhS2YLPCX_ZPOBhmSBm8MleYI1pmJxyYXWG5R7dGuUS7K-7Q-eX5_PhrTieXt8PT8di4oIXkkouNVSdqRQxIDjnPaV1V0GjdCXrSjBdMuB1rRmvGwJGUsGEUqUGqYxmO_T4l51i-Jwh5Xa0SYNzykOYU0tFTUvBhRCr-nBV526Evp2iHVVc2v-b2C-K72cV</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Belova, L A</creator><creator>Mashin, V V</creator><creator>Kolotik-Kameneva, O Yu</creator><creator>Proshin, A N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Cytoflavin® effect on endothelium function and cerebral hemodynamics in patients with hypertensive enceplalopathy</title><author>Belova, L A ; 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The arterial endothelium function was estimated and ultrasonic examination of the hemodynamics at five structurally functional levels of the cerebral vascular course was used. All the patients with HE had endothelial dysfunction, bloodstream depression in the arterial course of the brain vascular system, decreased reactivity of the intracranial veins, difficulty in venous outflow. In the course of the therapy with Cytoflavin restotation of the arterial endothelial function in the patients with HE I stage, the linear and volume speed of bloodstream in the main and intracranial cerebral arteries in the patients with HE I-II stages, restoration of the intracranial veins reactivity, the linear speed of bloodstream in intracranial veins in the patients with all three stages of HE, the linear speed of bloodstream in the main veins up to the control values in the patients with I-III stages of HE were observed. Interrelation between the values of the cerebral hemodynamics and the state of the endothelium function was shown.</abstract><cop>Russia (Federation)</cop><pmid>25975105</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Antibiotiki i himioterapiâ, 2014, Vol.59 (7-8), p.30-36 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals |
| subjects | Adult Aged Brain - blood supply Brain - drug effects Brain - pathology Cerebral Arteries - diagnostic imaging Cerebral Arteries - drug effects Cerebral Arteries - pathology Drug Administration Schedule Drug Combinations Endothelium, Vascular - diagnostic imaging Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Female Flavin Mononucleotide - pharmacology Hemodynamics - drug effects Humans Hypertensive Encephalopathy - diagnostic imaging Hypertensive Encephalopathy - drug therapy Hypertensive Encephalopathy - pathology Inosine Diphosphate - pharmacology Male Middle Aged Neuroprotective Agents - pharmacology Niacinamide - pharmacology Succinates - pharmacology Ultrasonography |
| title | Cytoflavin® effect on endothelium function and cerebral hemodynamics in patients with hypertensive enceplalopathy |
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