Risk factors for pericardial effusion in adult patients receiving allogeneic haematopoietic stem cell transplantation
Summary Pericardial effusion (PE) is a rare but potentially life‐threatening complication for allogeneic haematopoietic stem cell transplantation (HSCT) recipients. The risk factors, aetiology, incidence and therapy are largely unclear. To investigate this issue, we reviewed 391 adult patients under...
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| Veröffentlicht in: | British journal of haematology 2015-06, Vol.169 (5), p.737-745 |
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| container_title | British journal of haematology |
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| creator | Liu, Yao‐Chung Chien, Sheng‐Hsuan Fan, Nai‐Wen Hu, Ming‐Hung Gau, Jyh‐Pyng Liu, Chia‐Jen Yu, Yuan‐Bin Liu, Chun‐Yu Hsiao, Liang‐Tsai Liu, Jin‐Hwang Chiou, Tzeon‐Jye Tzeng, Cheng‐Hwai |
| description | Summary
Pericardial effusion (PE) is a rare but potentially life‐threatening complication for allogeneic haematopoietic stem cell transplantation (HSCT) recipients. The risk factors, aetiology, incidence and therapy are largely unclear. To investigate this issue, we reviewed 391 adult patients undergoing allogeneic HSCT between January 2003 and December 2013. Twelve out of 391 patients (3·1%) developed PE of moderate to large amounts, including 9 out of 12 patients (75%) identified as late‐onset PE. Two out of the nine patients with late‐onset PE experienced recurrent effusion. The median age at HSCT was 44·5 years (range: 22–63 years) among the 12 patients with PE and 47 years in the late‐onset patients. Multivariate analysis revealed that multiple transplant procedures was a significant risk factor for PE (P = 0·036) and a trend as risk factor in patients aged>50 years (P = 0·066). For late‐onset PE, pre‐transplant age>50 years (P = 0·032) and extensive chronic graft‐versus‐host disease (cGVHD) (P = 0·006) remained statistically significant on multivariate analysis. Currently, there are no published data exploring the risk factors for post‐transplant PE in adult patients of allogeneic HSCT. Our study determined the risk factors and incidence for the post‐transplant PE, especially in the late‐onset group. |
| doi_str_mv | 10.1111/bjh.13357 |
| format | Article |
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Pericardial effusion (PE) is a rare but potentially life‐threatening complication for allogeneic haematopoietic stem cell transplantation (HSCT) recipients. The risk factors, aetiology, incidence and therapy are largely unclear. To investigate this issue, we reviewed 391 adult patients undergoing allogeneic HSCT between January 2003 and December 2013. Twelve out of 391 patients (3·1%) developed PE of moderate to large amounts, including 9 out of 12 patients (75%) identified as late‐onset PE. Two out of the nine patients with late‐onset PE experienced recurrent effusion. The median age at HSCT was 44·5 years (range: 22–63 years) among the 12 patients with PE and 47 years in the late‐onset patients. Multivariate analysis revealed that multiple transplant procedures was a significant risk factor for PE (P = 0·036) and a trend as risk factor in patients aged>50 years (P = 0·066). For late‐onset PE, pre‐transplant age>50 years (P = 0·032) and extensive chronic graft‐versus‐host disease (cGVHD) (P = 0·006) remained statistically significant on multivariate analysis. Currently, there are no published data exploring the risk factors for post‐transplant PE in adult patients of allogeneic HSCT. Our study determined the risk factors and incidence for the post‐transplant PE, especially in the late‐onset group.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/bjh.13357</identifier><identifier>PMID: 25818840</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Adult ; Aged ; cardiac tamponade ; Female ; Graft vs Host Disease - etiology ; Graft vs Host Disease - prevention & control ; graft‐versus‐host disease ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Incidence ; Male ; Middle Aged ; Patient Outcome Assessment ; pericardial effusion ; Pericardial Effusion - epidemiology ; Pericardial Effusion - etiology ; Pericardial Effusion - mortality ; Retrospective Studies ; Risk Factors ; stem cell transplantation ; Transplantation Conditioning - adverse effects ; Transplantation, Homologous ; Young Adult</subject><ispartof>British journal of haematology, 2015-06, Vol.169 (5), p.737-745</ispartof><rights>2015 John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3917-4bb4844089c41d6310fc54b23b55e0c625cc851f30489fe958b41ee1944eec263</citedby><cites>FETCH-LOGICAL-c3917-4bb4844089c41d6310fc54b23b55e0c625cc851f30489fe958b41ee1944eec263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbjh.13357$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbjh.13357$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25818840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yao‐Chung</creatorcontrib><creatorcontrib>Chien, Sheng‐Hsuan</creatorcontrib><creatorcontrib>Fan, Nai‐Wen</creatorcontrib><creatorcontrib>Hu, Ming‐Hung</creatorcontrib><creatorcontrib>Gau, Jyh‐Pyng</creatorcontrib><creatorcontrib>Liu, Chia‐Jen</creatorcontrib><creatorcontrib>Yu, Yuan‐Bin</creatorcontrib><creatorcontrib>Liu, Chun‐Yu</creatorcontrib><creatorcontrib>Hsiao, Liang‐Tsai</creatorcontrib><creatorcontrib>Liu, Jin‐Hwang</creatorcontrib><creatorcontrib>Chiou, Tzeon‐Jye</creatorcontrib><creatorcontrib>Tzeng, Cheng‐Hwai</creatorcontrib><title>Risk factors for pericardial effusion in adult patients receiving allogeneic haematopoietic stem cell transplantation</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Pericardial effusion (PE) is a rare but potentially life‐threatening complication for allogeneic haematopoietic stem cell transplantation (HSCT) recipients. The risk factors, aetiology, incidence and therapy are largely unclear. To investigate this issue, we reviewed 391 adult patients undergoing allogeneic HSCT between January 2003 and December 2013. Twelve out of 391 patients (3·1%) developed PE of moderate to large amounts, including 9 out of 12 patients (75%) identified as late‐onset PE. Two out of the nine patients with late‐onset PE experienced recurrent effusion. The median age at HSCT was 44·5 years (range: 22–63 years) among the 12 patients with PE and 47 years in the late‐onset patients. Multivariate analysis revealed that multiple transplant procedures was a significant risk factor for PE (P = 0·036) and a trend as risk factor in patients aged>50 years (P = 0·066). For late‐onset PE, pre‐transplant age>50 years (P = 0·032) and extensive chronic graft‐versus‐host disease (cGVHD) (P = 0·006) remained statistically significant on multivariate analysis. Currently, there are no published data exploring the risk factors for post‐transplant PE in adult patients of allogeneic HSCT. Our study determined the risk factors and incidence for the post‐transplant PE, especially in the late‐onset group.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>cardiac tamponade</subject><subject>Female</subject><subject>Graft vs Host Disease - etiology</subject><subject>Graft vs Host Disease - prevention & control</subject><subject>graft‐versus‐host disease</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patient Outcome Assessment</subject><subject>pericardial effusion</subject><subject>Pericardial Effusion - epidemiology</subject><subject>Pericardial Effusion - etiology</subject><subject>Pericardial Effusion - mortality</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>stem cell transplantation</subject><subject>Transplantation Conditioning - adverse effects</subject><subject>Transplantation, Homologous</subject><subject>Young Adult</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFO3DAQhi0Egi3toS9Q-UgPAU9sZ51ju6JdEBISgnPkeMeLqWOntkPF25Pt0t6Yy2ikb37NfIR8BnYOc130T4_nwLlcHpAF8EZWNQg4JAvG2LICJtQJ-ZDzE2PAmYRjclJLBUoJtiDTncu_qNWmxJSpjYmOmJzRaeO0p2jtlF0M1AWqN5MvdNTFYSiZJjTonl3YUu193GJAZ-ijxkGXOEaHZR5zwYEa9J6WpEMevQ5l3o_hIzmy2mf89NZPycOPy_vVurq5_Xm1-nZTGd7CshJ9L5QQTLVGwKbhwKyRoq95LyUy09TSGCXB8vnF1mIrVS8AEVohEE3d8FNyts8dU_w9YS7d4PLuIB0wTrmDRkHdMCV36Nc9alLMOaHtxuQGnV46YN3Ocjdb7v5antkvb7FTP-DmP_lP6wxc7IE_zuPL-0nd9-v1PvIVQOCIPA</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Liu, Yao‐Chung</creator><creator>Chien, Sheng‐Hsuan</creator><creator>Fan, Nai‐Wen</creator><creator>Hu, Ming‐Hung</creator><creator>Gau, Jyh‐Pyng</creator><creator>Liu, Chia‐Jen</creator><creator>Yu, Yuan‐Bin</creator><creator>Liu, Chun‐Yu</creator><creator>Hsiao, Liang‐Tsai</creator><creator>Liu, Jin‐Hwang</creator><creator>Chiou, Tzeon‐Jye</creator><creator>Tzeng, Cheng‐Hwai</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201506</creationdate><title>Risk factors for pericardial effusion in adult patients receiving allogeneic haematopoietic stem cell transplantation</title><author>Liu, Yao‐Chung ; Chien, Sheng‐Hsuan ; Fan, Nai‐Wen ; Hu, Ming‐Hung ; Gau, Jyh‐Pyng ; Liu, Chia‐Jen ; Yu, Yuan‐Bin ; Liu, Chun‐Yu ; Hsiao, Liang‐Tsai ; Liu, Jin‐Hwang ; Chiou, Tzeon‐Jye ; Tzeng, Cheng‐Hwai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3917-4bb4844089c41d6310fc54b23b55e0c625cc851f30489fe958b41ee1944eec263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>cardiac tamponade</topic><topic>Female</topic><topic>Graft vs Host Disease - etiology</topic><topic>Graft vs Host Disease - prevention & control</topic><topic>graft‐versus‐host disease</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patient Outcome Assessment</topic><topic>pericardial effusion</topic><topic>Pericardial Effusion - epidemiology</topic><topic>Pericardial Effusion - etiology</topic><topic>Pericardial Effusion - mortality</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>stem cell transplantation</topic><topic>Transplantation Conditioning - adverse effects</topic><topic>Transplantation, Homologous</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yao‐Chung</creatorcontrib><creatorcontrib>Chien, Sheng‐Hsuan</creatorcontrib><creatorcontrib>Fan, Nai‐Wen</creatorcontrib><creatorcontrib>Hu, Ming‐Hung</creatorcontrib><creatorcontrib>Gau, Jyh‐Pyng</creatorcontrib><creatorcontrib>Liu, Chia‐Jen</creatorcontrib><creatorcontrib>Yu, Yuan‐Bin</creatorcontrib><creatorcontrib>Liu, Chun‐Yu</creatorcontrib><creatorcontrib>Hsiao, Liang‐Tsai</creatorcontrib><creatorcontrib>Liu, Jin‐Hwang</creatorcontrib><creatorcontrib>Chiou, Tzeon‐Jye</creatorcontrib><creatorcontrib>Tzeng, Cheng‐Hwai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yao‐Chung</au><au>Chien, Sheng‐Hsuan</au><au>Fan, Nai‐Wen</au><au>Hu, Ming‐Hung</au><au>Gau, Jyh‐Pyng</au><au>Liu, Chia‐Jen</au><au>Yu, Yuan‐Bin</au><au>Liu, Chun‐Yu</au><au>Hsiao, Liang‐Tsai</au><au>Liu, Jin‐Hwang</au><au>Chiou, Tzeon‐Jye</au><au>Tzeng, Cheng‐Hwai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for pericardial effusion in adult patients receiving allogeneic haematopoietic stem cell transplantation</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2015-06</date><risdate>2015</risdate><volume>169</volume><issue>5</issue><spage>737</spage><epage>745</epage><pages>737-745</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><abstract>Summary
Pericardial effusion (PE) is a rare but potentially life‐threatening complication for allogeneic haematopoietic stem cell transplantation (HSCT) recipients. The risk factors, aetiology, incidence and therapy are largely unclear. To investigate this issue, we reviewed 391 adult patients undergoing allogeneic HSCT between January 2003 and December 2013. Twelve out of 391 patients (3·1%) developed PE of moderate to large amounts, including 9 out of 12 patients (75%) identified as late‐onset PE. Two out of the nine patients with late‐onset PE experienced recurrent effusion. The median age at HSCT was 44·5 years (range: 22–63 years) among the 12 patients with PE and 47 years in the late‐onset patients. Multivariate analysis revealed that multiple transplant procedures was a significant risk factor for PE (P = 0·036) and a trend as risk factor in patients aged>50 years (P = 0·066). For late‐onset PE, pre‐transplant age>50 years (P = 0·032) and extensive chronic graft‐versus‐host disease (cGVHD) (P = 0·006) remained statistically significant on multivariate analysis. Currently, there are no published data exploring the risk factors for post‐transplant PE in adult patients of allogeneic HSCT. Our study determined the risk factors and incidence for the post‐transplant PE, especially in the late‐onset group.</abstract><cop>England</cop><pmid>25818840</pmid><doi>10.1111/bjh.13357</doi><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Adult Aged cardiac tamponade Female Graft vs Host Disease - etiology Graft vs Host Disease - prevention & control graft‐versus‐host disease Hematopoietic Stem Cell Transplantation - adverse effects Humans Incidence Male Middle Aged Patient Outcome Assessment pericardial effusion Pericardial Effusion - epidemiology Pericardial Effusion - etiology Pericardial Effusion - mortality Retrospective Studies Risk Factors stem cell transplantation Transplantation Conditioning - adverse effects Transplantation, Homologous Young Adult |
| title | Risk factors for pericardial effusion in adult patients receiving allogeneic haematopoietic stem cell transplantation |
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