Periodontal regeneration employing gingival margin-derived stem/progenitor cells in conjunction with IL-1ra-hydrogel synthetic extracellular matrix
Aim This study investigated the periodontal regenerative potential of gingival margin‐derived stem/progenitor cells (G‐MSCs) in conjunction with IL‐1ra‐releasing hyaluronic acid synthetic extracellular matrix (HA‐sECM). Materials and Methods Periodontal defects were induced at four sites in eight mi...
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| Veröffentlicht in: | Journal of clinical periodontology 2015-05, Vol.42 (5), p.448-457 |
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| creator | Fawzy El-Sayed, Karim M. Mekhemar, Mohamed K. Beck-Broichsitter, Benedicta E. Bähr, Telse Hegab, Marwa Receveur, Jan Heneweer, Carola Becker, Stephan T. Wiltfang, Joerg Dörfer, Christof E. |
| description | Aim
This study investigated the periodontal regenerative potential of gingival margin‐derived stem/progenitor cells (G‐MSCs) in conjunction with IL‐1ra‐releasing hyaluronic acid synthetic extracellular matrix (HA‐sECM).
Materials and Methods
Periodontal defects were induced at four sites in eight miniature pigs in the premolar/molar area (−4 weeks). Autologus G‐MSCs were isolated from the free gingival margin and magnetically sorted, using anti‐STRO‐1 antibodies. Colony formation and multilineage differentiation potential were tested. The G‐MSCs were expanded and incorporated into IL‐1ra‐loaded/unloaded HA‐sECM. Within every miniature pig, four periodontal defects were randomly treated with IL‐1ra/G‐MSCs/HA‐sECM (test group), G‐MSCs/HA‐sECM (positive‐control), scaling and root planing (SRP; negative control‐1) or left untreated (no‐treatment group; negative control 2). Differences in clinical attachment level (ΔCAL), probing depth (ΔPD), gingival recession (ΔGR), radiographic defect volume (ΔRDV), and changes in bleeding on probing (BOP) between baseline and 16 weeks post‐transplantation, as well as periodontal attachment level (PAL), junctional epithelium length (JE), connective tissue adhesion (CTA), cementum regeneration (CR) and bone regeneration (BR) at 16 weeks post‐transplantation were evaluated.
Results
Isolated G‐MSCs showed stem/progenitor cell characteristics. IL‐1ra loaded and unloaded G‐MSCs/HA‐sECM showed higher ΔCAL, ΔPD, ΔGR, PAL, CR and BR as well as a lower JE compared to their negative controls and improved BOP.
Conclusion
G‐MSCs in conjunction with IL‐1ra‐loaded/unloaded HA‐sECM show a significant periodontal regenerative potential. |
| doi_str_mv | 10.1111/jcpe.12401 |
| format | Article |
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This study investigated the periodontal regenerative potential of gingival margin‐derived stem/progenitor cells (G‐MSCs) in conjunction with IL‐1ra‐releasing hyaluronic acid synthetic extracellular matrix (HA‐sECM).
Materials and Methods
Periodontal defects were induced at four sites in eight miniature pigs in the premolar/molar area (−4 weeks). Autologus G‐MSCs were isolated from the free gingival margin and magnetically sorted, using anti‐STRO‐1 antibodies. Colony formation and multilineage differentiation potential were tested. The G‐MSCs were expanded and incorporated into IL‐1ra‐loaded/unloaded HA‐sECM. Within every miniature pig, four periodontal defects were randomly treated with IL‐1ra/G‐MSCs/HA‐sECM (test group), G‐MSCs/HA‐sECM (positive‐control), scaling and root planing (SRP; negative control‐1) or left untreated (no‐treatment group; negative control 2). Differences in clinical attachment level (ΔCAL), probing depth (ΔPD), gingival recession (ΔGR), radiographic defect volume (ΔRDV), and changes in bleeding on probing (BOP) between baseline and 16 weeks post‐transplantation, as well as periodontal attachment level (PAL), junctional epithelium length (JE), connective tissue adhesion (CTA), cementum regeneration (CR) and bone regeneration (BR) at 16 weeks post‐transplantation were evaluated.
Results
Isolated G‐MSCs showed stem/progenitor cell characteristics. IL‐1ra loaded and unloaded G‐MSCs/HA‐sECM showed higher ΔCAL, ΔPD, ΔGR, PAL, CR and BR as well as a lower JE compared to their negative controls and improved BOP.
Conclusion
G‐MSCs in conjunction with IL‐1ra‐loaded/unloaded HA‐sECM show a significant periodontal regenerative potential.</description><identifier>ISSN: 0303-6979</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/jcpe.12401</identifier><identifier>PMID: 25875208</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Alveolar Bone Loss - therapy ; Animals ; Bone Regeneration - physiology ; Cell Differentiation - physiology ; Cementogenesis - physiology ; Connective Tissue - pathology ; Dental Scaling - methods ; Dentistry ; Epithelial Attachment - pathology ; Female ; gingiva ; Gingiva - cytology ; Gingival Recession - therapy ; Guided Tissue Regeneration, Periodontal - methods ; Gum disease ; Hyaluronic Acid - chemistry ; hydrogel ; Hydrogels - chemistry ; IL-1ra ; Interleukin 1 Receptor Antagonist Protein - therapeutic use ; Male ; Periodontal Attachment Loss - therapy ; Periodontal Index ; Periodontal Pocket - therapy ; periodontitis ; Periodontitis - therapy ; Random Allocation ; regeneration ; Root Planing - methods ; Stem Cell Transplantation - methods ; stem cells ; Stem Cells - physiology ; Swine ; Swine, Miniature ; Tissue Scaffolds - chemistry</subject><ispartof>Journal of clinical periodontology, 2015-05, Vol.42 (5), p.448-457</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2015 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3951-dc62bf60eda727ab61f52472a6fd8db744e8ff89983023360f78203c70f6409e3</citedby><cites>FETCH-LOGICAL-c3951-dc62bf60eda727ab61f52472a6fd8db744e8ff89983023360f78203c70f6409e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpe.12401$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpe.12401$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25875208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fawzy El-Sayed, Karim M.</creatorcontrib><creatorcontrib>Mekhemar, Mohamed K.</creatorcontrib><creatorcontrib>Beck-Broichsitter, Benedicta E.</creatorcontrib><creatorcontrib>Bähr, Telse</creatorcontrib><creatorcontrib>Hegab, Marwa</creatorcontrib><creatorcontrib>Receveur, Jan</creatorcontrib><creatorcontrib>Heneweer, Carola</creatorcontrib><creatorcontrib>Becker, Stephan T.</creatorcontrib><creatorcontrib>Wiltfang, Joerg</creatorcontrib><creatorcontrib>Dörfer, Christof E.</creatorcontrib><title>Periodontal regeneration employing gingival margin-derived stem/progenitor cells in conjunction with IL-1ra-hydrogel synthetic extracellular matrix</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>Aim
This study investigated the periodontal regenerative potential of gingival margin‐derived stem/progenitor cells (G‐MSCs) in conjunction with IL‐1ra‐releasing hyaluronic acid synthetic extracellular matrix (HA‐sECM).
Materials and Methods
Periodontal defects were induced at four sites in eight miniature pigs in the premolar/molar area (−4 weeks). Autologus G‐MSCs were isolated from the free gingival margin and magnetically sorted, using anti‐STRO‐1 antibodies. Colony formation and multilineage differentiation potential were tested. The G‐MSCs were expanded and incorporated into IL‐1ra‐loaded/unloaded HA‐sECM. Within every miniature pig, four periodontal defects were randomly treated with IL‐1ra/G‐MSCs/HA‐sECM (test group), G‐MSCs/HA‐sECM (positive‐control), scaling and root planing (SRP; negative control‐1) or left untreated (no‐treatment group; negative control 2). Differences in clinical attachment level (ΔCAL), probing depth (ΔPD), gingival recession (ΔGR), radiographic defect volume (ΔRDV), and changes in bleeding on probing (BOP) between baseline and 16 weeks post‐transplantation, as well as periodontal attachment level (PAL), junctional epithelium length (JE), connective tissue adhesion (CTA), cementum regeneration (CR) and bone regeneration (BR) at 16 weeks post‐transplantation were evaluated.
Results
Isolated G‐MSCs showed stem/progenitor cell characteristics. IL‐1ra loaded and unloaded G‐MSCs/HA‐sECM showed higher ΔCAL, ΔPD, ΔGR, PAL, CR and BR as well as a lower JE compared to their negative controls and improved BOP.
Conclusion
G‐MSCs in conjunction with IL‐1ra‐loaded/unloaded HA‐sECM show a significant periodontal regenerative potential.</description><subject>Alveolar Bone Loss - therapy</subject><subject>Animals</subject><subject>Bone Regeneration - physiology</subject><subject>Cell Differentiation - physiology</subject><subject>Cementogenesis - physiology</subject><subject>Connective Tissue - pathology</subject><subject>Dental Scaling - methods</subject><subject>Dentistry</subject><subject>Epithelial Attachment - pathology</subject><subject>Female</subject><subject>gingiva</subject><subject>Gingiva - cytology</subject><subject>Gingival Recession - therapy</subject><subject>Guided Tissue Regeneration, Periodontal - methods</subject><subject>Gum disease</subject><subject>Hyaluronic Acid - chemistry</subject><subject>hydrogel</subject><subject>Hydrogels - chemistry</subject><subject>IL-1ra</subject><subject>Interleukin 1 Receptor Antagonist Protein - therapeutic use</subject><subject>Male</subject><subject>Periodontal Attachment Loss - therapy</subject><subject>Periodontal Index</subject><subject>Periodontal Pocket - therapy</subject><subject>periodontitis</subject><subject>Periodontitis - therapy</subject><subject>Random Allocation</subject><subject>regeneration</subject><subject>Root Planing - methods</subject><subject>Stem Cell Transplantation - methods</subject><subject>stem cells</subject><subject>Stem Cells - physiology</subject><subject>Swine</subject><subject>Swine, Miniature</subject><subject>Tissue Scaffolds - chemistry</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAURSMEokNhwwcgS2wQUtpnO7GdJQxtKRqVLopAbCxP4sx4SOzBdtrJd_SH63TaLljghW3pnXv9nm-WvcVwhNM63tRbfYRJAfhZNsMMIIcS_3qezYACzVnFq4PsVQgbAMwppS-zA1IKXhIQs-z2UnvjGmej6pDXK221V9E4i3S_7dxo7Aqt0mauU71XPt3zJkmudYNC1P3x1rskMtF5VOuuC8hYVDu7GWx9b3Nj4hqdL3LsVb4em4nuUBhtXOtoaqR30atJOHTKpweiN7vX2YtWdUG_eTgPsx-nJ1fzr_ni-9n5_NMir2lV4rypGVm2DHSjOOFqyXBbkoITxdpGNEteFFq0ragqQYFQyqDlggCtObSsgErTw-zD3jfN8HfQIcrehKkXZbUbgsRMYMKgYJDQ9_-gGzd4m7qbKGAlpaJK1Mc9VXsXgtet3HqTPm2UGOQUlZyikvdRJfjdg-Ww7HXzhD5mkwC8B25Mp8f_WMlv88uTR9N8rzEpnN2TRvk_knHKS_nz4kxeVb9PL8SXz3JB7wC1ZrCn</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Fawzy El-Sayed, Karim M.</creator><creator>Mekhemar, Mohamed K.</creator><creator>Beck-Broichsitter, Benedicta E.</creator><creator>Bähr, Telse</creator><creator>Hegab, Marwa</creator><creator>Receveur, Jan</creator><creator>Heneweer, Carola</creator><creator>Becker, Stephan T.</creator><creator>Wiltfang, Joerg</creator><creator>Dörfer, Christof E.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201505</creationdate><title>Periodontal regeneration employing gingival margin-derived stem/progenitor cells in conjunction with IL-1ra-hydrogel synthetic extracellular matrix</title><author>Fawzy El-Sayed, Karim M. ; Mekhemar, Mohamed K. ; Beck-Broichsitter, Benedicta E. ; Bähr, Telse ; Hegab, Marwa ; Receveur, Jan ; Heneweer, Carola ; Becker, Stephan T. ; Wiltfang, Joerg ; Dörfer, Christof E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3951-dc62bf60eda727ab61f52472a6fd8db744e8ff89983023360f78203c70f6409e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alveolar Bone Loss - therapy</topic><topic>Animals</topic><topic>Bone Regeneration - physiology</topic><topic>Cell Differentiation - physiology</topic><topic>Cementogenesis - physiology</topic><topic>Connective Tissue - pathology</topic><topic>Dental Scaling - methods</topic><topic>Dentistry</topic><topic>Epithelial Attachment - pathology</topic><topic>Female</topic><topic>gingiva</topic><topic>Gingiva - cytology</topic><topic>Gingival Recession - therapy</topic><topic>Guided Tissue Regeneration, Periodontal - methods</topic><topic>Gum disease</topic><topic>Hyaluronic Acid - chemistry</topic><topic>hydrogel</topic><topic>Hydrogels - chemistry</topic><topic>IL-1ra</topic><topic>Interleukin 1 Receptor Antagonist Protein - therapeutic use</topic><topic>Male</topic><topic>Periodontal Attachment Loss - therapy</topic><topic>Periodontal Index</topic><topic>Periodontal Pocket - therapy</topic><topic>periodontitis</topic><topic>Periodontitis - therapy</topic><topic>Random Allocation</topic><topic>regeneration</topic><topic>Root Planing - methods</topic><topic>Stem Cell Transplantation - methods</topic><topic>stem cells</topic><topic>Stem Cells - physiology</topic><topic>Swine</topic><topic>Swine, Miniature</topic><topic>Tissue Scaffolds - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fawzy El-Sayed, Karim M.</creatorcontrib><creatorcontrib>Mekhemar, Mohamed K.</creatorcontrib><creatorcontrib>Beck-Broichsitter, Benedicta E.</creatorcontrib><creatorcontrib>Bähr, Telse</creatorcontrib><creatorcontrib>Hegab, Marwa</creatorcontrib><creatorcontrib>Receveur, Jan</creatorcontrib><creatorcontrib>Heneweer, Carola</creatorcontrib><creatorcontrib>Becker, Stephan T.</creatorcontrib><creatorcontrib>Wiltfang, Joerg</creatorcontrib><creatorcontrib>Dörfer, Christof E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fawzy El-Sayed, Karim M.</au><au>Mekhemar, Mohamed K.</au><au>Beck-Broichsitter, Benedicta E.</au><au>Bähr, Telse</au><au>Hegab, Marwa</au><au>Receveur, Jan</au><au>Heneweer, Carola</au><au>Becker, Stephan T.</au><au>Wiltfang, Joerg</au><au>Dörfer, Christof E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Periodontal regeneration employing gingival margin-derived stem/progenitor cells in conjunction with IL-1ra-hydrogel synthetic extracellular matrix</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>2015-05</date><risdate>2015</risdate><volume>42</volume><issue>5</issue><spage>448</spage><epage>457</epage><pages>448-457</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>Aim
This study investigated the periodontal regenerative potential of gingival margin‐derived stem/progenitor cells (G‐MSCs) in conjunction with IL‐1ra‐releasing hyaluronic acid synthetic extracellular matrix (HA‐sECM).
Materials and Methods
Periodontal defects were induced at four sites in eight miniature pigs in the premolar/molar area (−4 weeks). Autologus G‐MSCs were isolated from the free gingival margin and magnetically sorted, using anti‐STRO‐1 antibodies. Colony formation and multilineage differentiation potential were tested. The G‐MSCs were expanded and incorporated into IL‐1ra‐loaded/unloaded HA‐sECM. Within every miniature pig, four periodontal defects were randomly treated with IL‐1ra/G‐MSCs/HA‐sECM (test group), G‐MSCs/HA‐sECM (positive‐control), scaling and root planing (SRP; negative control‐1) or left untreated (no‐treatment group; negative control 2). Differences in clinical attachment level (ΔCAL), probing depth (ΔPD), gingival recession (ΔGR), radiographic defect volume (ΔRDV), and changes in bleeding on probing (BOP) between baseline and 16 weeks post‐transplantation, as well as periodontal attachment level (PAL), junctional epithelium length (JE), connective tissue adhesion (CTA), cementum regeneration (CR) and bone regeneration (BR) at 16 weeks post‐transplantation were evaluated.
Results
Isolated G‐MSCs showed stem/progenitor cell characteristics. IL‐1ra loaded and unloaded G‐MSCs/HA‐sECM showed higher ΔCAL, ΔPD, ΔGR, PAL, CR and BR as well as a lower JE compared to their negative controls and improved BOP.
Conclusion
G‐MSCs in conjunction with IL‐1ra‐loaded/unloaded HA‐sECM show a significant periodontal regenerative potential.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25875208</pmid><doi>10.1111/jcpe.12401</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of clinical periodontology, 2015-05, Vol.42 (5), p.448-457 |
| issn | 0303-6979 1600-051X |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alveolar Bone Loss - therapy Animals Bone Regeneration - physiology Cell Differentiation - physiology Cementogenesis - physiology Connective Tissue - pathology Dental Scaling - methods Dentistry Epithelial Attachment - pathology Female gingiva Gingiva - cytology Gingival Recession - therapy Guided Tissue Regeneration, Periodontal - methods Gum disease Hyaluronic Acid - chemistry hydrogel Hydrogels - chemistry IL-1ra Interleukin 1 Receptor Antagonist Protein - therapeutic use Male Periodontal Attachment Loss - therapy Periodontal Index Periodontal Pocket - therapy periodontitis Periodontitis - therapy Random Allocation regeneration Root Planing - methods Stem Cell Transplantation - methods stem cells Stem Cells - physiology Swine Swine, Miniature Tissue Scaffolds - chemistry |
| title | Periodontal regeneration employing gingival margin-derived stem/progenitor cells in conjunction with IL-1ra-hydrogel synthetic extracellular matrix |
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