Atrial fibrillation: A major risk factor for cognitive decline
Atrial fibrillation is a common disease of the elderly, conferring considerable morbidity and mortality related to cardiovascular effects and thromboembolic risks. Anticoagulation, antiarrhythmic medications, and rate control are the cornerstone of contemporary management, whereas ablation and evolv...
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| Veröffentlicht in: | The American heart journal 2015-04, Vol.169 (4), p.448-456 |
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| creator | Hui, Dawn S., MD Morley, John E., MB, BCh Mikolajczak, Peter C., MD Lee, Richard, MD, MBA |
| description | Atrial fibrillation is a common disease of the elderly, conferring considerable morbidity and mortality related to cardiovascular effects and thromboembolic risks. Anticoagulation, antiarrhythmic medications, and rate control are the cornerstone of contemporary management, whereas ablation and evolving surgical techniques continue to play important secondary roles. Growing evidence shows that atrial fibrillation is also a risk factor for significant cognitive decline through a multitude of pathways, further contributing to morbidity and mortality. At the same time, cognitive decline associated with cryptogenic strokes may be the first clue to previously undiagnosed atrial fibrillation. These overlapping associations support the concept of cognitive screening and rhythm monitoring in these populations. New research suggests modulating effects of currently accepted treatments for atrial fibrillation on cognition; however, there remains the need for large multicenter studies to examine the effects of novel oral anticoagulants, rhythm and rate control, and left atrial appendage occlusion on long-term cognitive function. |
| doi_str_mv | 10.1016/j.ahj.2014.12.015 |
| format | Article |
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Anticoagulation, antiarrhythmic medications, and rate control are the cornerstone of contemporary management, whereas ablation and evolving surgical techniques continue to play important secondary roles. Growing evidence shows that atrial fibrillation is also a risk factor for significant cognitive decline through a multitude of pathways, further contributing to morbidity and mortality. At the same time, cognitive decline associated with cryptogenic strokes may be the first clue to previously undiagnosed atrial fibrillation. These overlapping associations support the concept of cognitive screening and rhythm monitoring in these populations. New research suggests modulating effects of currently accepted treatments for atrial fibrillation on cognition; however, there remains the need for large multicenter studies to examine the effects of novel oral anticoagulants, rhythm and rate control, and left atrial appendage occlusion on long-term cognitive function.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/j.ahj.2014.12.015</identifier><identifier>PMID: 25819850</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age ; Atrial Fibrillation - complications ; Atrial Fibrillation - physiopathology ; Biomarkers ; Blood clots ; Cardiac arrhythmia ; Cardiovascular ; Cognition - physiology ; Cognition Disorders - epidemiology ; Cognition Disorders - etiology ; Cognition Disorders - psychology ; Cognitive ability ; Epidemiology ; Flow velocity ; Global Health ; Humans ; Incidence ; Ischemia ; Older people ; Proteins ; Risk Factors ; Sinuses ; Stroke ; Studies</subject><ispartof>The American heart journal, 2015-04, Vol.169 (4), p.448-456</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Apr 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-bbd42db0ea64756aa39fd67b49a740cfdf0707bd76d94a27059008b5cb7f723c3</citedby><cites>FETCH-LOGICAL-c572t-bbd42db0ea64756aa39fd67b49a740cfdf0707bd76d94a27059008b5cb7f723c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1667271710?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993,64383,64385,64387,72239</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25819850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hui, Dawn S., MD</creatorcontrib><creatorcontrib>Morley, John E., MB, BCh</creatorcontrib><creatorcontrib>Mikolajczak, Peter C., MD</creatorcontrib><creatorcontrib>Lee, Richard, MD, MBA</creatorcontrib><title>Atrial fibrillation: A major risk factor for cognitive decline</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Atrial fibrillation is a common disease of the elderly, conferring considerable morbidity and mortality related to cardiovascular effects and thromboembolic risks. Anticoagulation, antiarrhythmic medications, and rate control are the cornerstone of contemporary management, whereas ablation and evolving surgical techniques continue to play important secondary roles. Growing evidence shows that atrial fibrillation is also a risk factor for significant cognitive decline through a multitude of pathways, further contributing to morbidity and mortality. At the same time, cognitive decline associated with cryptogenic strokes may be the first clue to previously undiagnosed atrial fibrillation. These overlapping associations support the concept of cognitive screening and rhythm monitoring in these populations. New research suggests modulating effects of currently accepted treatments for atrial fibrillation on cognition; however, there remains the need for large multicenter studies to examine the effects of novel oral anticoagulants, rhythm and rate control, and left atrial appendage occlusion on long-term cognitive function.</description><subject>Age</subject><subject>Atrial Fibrillation - complications</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Biomarkers</subject><subject>Blood clots</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular</subject><subject>Cognition - physiology</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - psychology</subject><subject>Cognitive ability</subject><subject>Epidemiology</subject><subject>Flow velocity</subject><subject>Global Health</subject><subject>Humans</subject><subject>Incidence</subject><subject>Ischemia</subject><subject>Older people</subject><subject>Proteins</subject><subject>Risk Factors</subject><subject>Sinuses</subject><subject>Stroke</subject><subject>Studies</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1LHTEUhoNU6tX2B7gpA924mfEkM0lmKggXqVYQXGjXIR8nbca5M5rMFfz3zXCtBRddhJzA8x5OnkPIMYWKAhWnfaV_9xUD2lSUVUD5HllR6GQpZNN8ICsAYGUroT4ghyn1-SlYKz6SA8Zb2rUcVuR8Pcegh8IHE8Mw6DlM47diXWx0P8UihvRQeG3nXPt87PRrDHN4xsKhHcKIn8i-10PCz6_3Efl5-f3-4kd5c3t1fbG-KS2XbC6NcQ1zBlCLRnKhdd15J6RpOi0bsN55kCCNk8J1jWYSeAfQGm6N9JLVtj4iJ7u-j3F62mKa1SYki3ngEadtUlS0lPGu7SCjX9-h_bSNY54uU0IySSVdKLqjbJxSiujVYwwbHV8UBbXIVb3KctUiV1Gmstyc-fLaeWs26N4Sf21m4GwHYFbxHDCqZAOOFl2IaGflpvDf9ufv0oviYPXwgC-Y_v1CpRxQd8t2l-VSnivgbf0HyXWc7w</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Hui, Dawn S., MD</creator><creator>Morley, John E., MB, BCh</creator><creator>Mikolajczak, Peter C., MD</creator><creator>Lee, Richard, MD, MBA</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150401</creationdate><title>Atrial fibrillation: A major risk factor for cognitive decline</title><author>Hui, Dawn S., MD ; Morley, John E., MB, BCh ; Mikolajczak, Peter C., MD ; Lee, Richard, MD, MBA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-bbd42db0ea64756aa39fd67b49a740cfdf0707bd76d94a27059008b5cb7f723c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age</topic><topic>Atrial Fibrillation - complications</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Biomarkers</topic><topic>Blood clots</topic><topic>Cardiac arrhythmia</topic><topic>Cardiovascular</topic><topic>Cognition - physiology</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - psychology</topic><topic>Cognitive ability</topic><topic>Epidemiology</topic><topic>Flow velocity</topic><topic>Global Health</topic><topic>Humans</topic><topic>Incidence</topic><topic>Ischemia</topic><topic>Older people</topic><topic>Proteins</topic><topic>Risk Factors</topic><topic>Sinuses</topic><topic>Stroke</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hui, Dawn S., MD</creatorcontrib><creatorcontrib>Morley, John E., MB, BCh</creatorcontrib><creatorcontrib>Mikolajczak, Peter C., MD</creatorcontrib><creatorcontrib>Lee, Richard, MD, MBA</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hui, Dawn S., MD</au><au>Morley, John E., MB, BCh</au><au>Mikolajczak, Peter C., MD</au><au>Lee, Richard, MD, MBA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atrial fibrillation: A major risk factor for cognitive decline</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>169</volume><issue>4</issue><spage>448</spage><epage>456</epage><pages>448-456</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>Atrial fibrillation is a common disease of the elderly, conferring considerable morbidity and mortality related to cardiovascular effects and thromboembolic risks. Anticoagulation, antiarrhythmic medications, and rate control are the cornerstone of contemporary management, whereas ablation and evolving surgical techniques continue to play important secondary roles. Growing evidence shows that atrial fibrillation is also a risk factor for significant cognitive decline through a multitude of pathways, further contributing to morbidity and mortality. At the same time, cognitive decline associated with cryptogenic strokes may be the first clue to previously undiagnosed atrial fibrillation. These overlapping associations support the concept of cognitive screening and rhythm monitoring in these populations. 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| ispartof | The American heart journal, 2015-04, Vol.169 (4), p.448-456 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Age Atrial Fibrillation - complications Atrial Fibrillation - physiopathology Biomarkers Blood clots Cardiac arrhythmia Cardiovascular Cognition - physiology Cognition Disorders - epidemiology Cognition Disorders - etiology Cognition Disorders - psychology Cognitive ability Epidemiology Flow velocity Global Health Humans Incidence Ischemia Older people Proteins Risk Factors Sinuses Stroke Studies |
| title | Atrial fibrillation: A major risk factor for cognitive decline |
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