Extraction, characterization of a Ginseng fruits polysaccharide and its immune modulating activities in rats with Lewis lung carcinoma

•A Ginseng fruit polysaccharide (GFP1) is purified and characterized.•GFP1 inhibits the tumor growth of Lewis lung carcinoma (LLC) in C57BL/6 mice.•GFP1 improves anti-tumor immune response in LLC-bearing C57BL/6 mice.•GFP1 could act as anti-tumor agent with immunomodulatory activity. In this study,...

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Veröffentlicht in:	Carbohydrate polymers 2015-08, Vol.127, p.215-221
Hauptverfasser:	Wang, Yingyu, Huang, Miaoyi, Sun, Ruilin, Pan, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antitumor activity Carcinoma, Lewis Lung - drug therapy CD4-CD8 Ratio Cell Line, Tumor Cell Proliferation Fruits Immunologic Factors - chemistry Immunologic Factors - pharmacology Immunologic Factors - therapeutic use Immunological activity Interferon-gamma - genetics Interferon-gamma - metabolism Interleukin-2 - genetics Interleukin-2 - metabolism Lewis lung carcinoma (LLC) Lymphocytes - drug effects Mice Mice, Inbred C57BL Panax - chemistry Panax ginseng Polysaccharides - chemistry Polysaccharides - pharmacology Polysaccharides - therapeutic use Polysacchride Rats
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