Transcutaneous delivery of leflunomide nanoemulgel: Mechanistic investigation into physicomechanical characteristics, in vitro anti-psoriatic and anti-melanoma activity

[Display omitted] •Mechanistic study of transcutaneous delivery of leflunomide.•Physicomechanical characterization of nanoemulgel using Texture Analyzer.•Ex vivo dermatokinetics for determination of permeation flux.•Enhanced cytotoxicity in HaCaT, A375 and SK-MEL2 cell lines.•Potential therapeutic a...

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Veröffentlicht in:	International journal of pharmaceutics 2015-06, Vol.487 (1-2), p.148-156
Hauptverfasser:	Pund, Swati, Pawar, Satish, Gangurde, Shashikant, Divate, Deepali
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesiveness Administration, Cutaneous Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Cell Line, Tumor Chemistry, Pharmaceutical Drug Stability Emulsions Ex vivo permeation Excipients Gels Hardness Tests Humans Isoxazoles - administration & dosage Isoxazoles - pharmacology Leflunomide Melanoma Melanoma - drug therapy Nanoemulgel Nanostructures Particle Size Psoriasis Psoriasis - drug therapy Skin Absorption Texture profile analysis Viscosity
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