Surface Modification of Multipass Caliber-Rolled Ti Alloy with Dexamethasone-Loaded Graphene for Dental Applications
Titanium (Ti) and its alloys with a high mechanical strength and a small diameter can be effectively exploited for minimally invasive dental implantation. Here, we report a multipass caliber-rolled Ti alloy of Ti13Nb13Zr (MPCR-TNZ) with a high mechanical strength and strong fatigue characteristics....
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| Veröffentlicht in: | ACS applied materials & interfaces 2015-05, Vol.7 (18), p.9598-9607 |
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| creator | Jung, Ho Sang Lee, Taekyung Kwon, Il Keun Kim, Hyoung Seop Hahn, Sei Kwang Lee, Chong Soo |
| description | Titanium (Ti) and its alloys with a high mechanical strength and a small diameter can be effectively exploited for minimally invasive dental implantation. Here, we report a multipass caliber-rolled Ti alloy of Ti13Nb13Zr (MPCR-TNZ) with a high mechanical strength and strong fatigue characteristics. For further dental applications, MPCR-TNZ was surface-modified with reduced graphene oxide (RGO) and loaded with osteogenic dexamethasone (Dex) via π–π stacking on the graphitic domain of RGO. The Dex-loaded RGO-MPCR-TNZ (Dex/RGO-MPCR-TNZ) resulted in significantly enhanced growth and differentiation of MC3T3-E1 cells into osteoblasts, which was confirmed by Alizarin red staining, alkaline phosphatase activity test, immunocytochemistry, and real-time PCR. Moreover, we could confirm the feasibility of Dex/RGO-MPCR-TNZ from the implantation test of a prototype of a dental implant to an artificial bone block for clinical dental applications. |
| doi_str_mv | 10.1021/acsami.5b03431 |
| format | Article |
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Here, we report a multipass caliber-rolled Ti alloy of Ti13Nb13Zr (MPCR-TNZ) with a high mechanical strength and strong fatigue characteristics. For further dental applications, MPCR-TNZ was surface-modified with reduced graphene oxide (RGO) and loaded with osteogenic dexamethasone (Dex) via π–π stacking on the graphitic domain of RGO. The Dex-loaded RGO-MPCR-TNZ (Dex/RGO-MPCR-TNZ) resulted in significantly enhanced growth and differentiation of MC3T3-E1 cells into osteoblasts, which was confirmed by Alizarin red staining, alkaline phosphatase activity test, immunocytochemistry, and real-time PCR. Moreover, we could confirm the feasibility of Dex/RGO-MPCR-TNZ from the implantation test of a prototype of a dental implant to an artificial bone block for clinical dental applications.</description><identifier>ISSN: 1944-8244</identifier><identifier>EISSN: 1944-8252</identifier><identifier>DOI: 10.1021/acsami.5b03431</identifier><identifier>PMID: 25909563</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Alloys - chemistry ; Animals ; Cell Differentiation - drug effects ; Cell Line ; Cell Survival - drug effects ; Dentistry - methods ; Dexamethasone - pharmacology ; Fluorescent Antibody Technique ; Gene Expression Regulation - drug effects ; Graphite - chemistry ; Mechanical Phenomena ; Mice ; Microscopy, Atomic Force ; Osteoblasts - cytology ; Osteoblasts - drug effects ; Oxidation-Reduction ; Stem Cells - cytology ; Stem Cells - drug effects ; Surface Properties ; Titanium - chemistry</subject><ispartof>ACS applied materials & interfaces, 2015-05, Vol.7 (18), p.9598-9607</ispartof><rights>Copyright © American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a330t-6733f3184f8d8e7466a2c3b5c384196593fee3a0e669b385eb439640609008173</citedby><cites>FETCH-LOGICAL-a330t-6733f3184f8d8e7466a2c3b5c384196593fee3a0e669b385eb439640609008173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsami.5b03431$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsami.5b03431$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27055,27903,27904,56716,56766</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25909563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Ho Sang</creatorcontrib><creatorcontrib>Lee, Taekyung</creatorcontrib><creatorcontrib>Kwon, Il Keun</creatorcontrib><creatorcontrib>Kim, Hyoung Seop</creatorcontrib><creatorcontrib>Hahn, Sei Kwang</creatorcontrib><creatorcontrib>Lee, Chong Soo</creatorcontrib><title>Surface Modification of Multipass Caliber-Rolled Ti Alloy with Dexamethasone-Loaded Graphene for Dental Applications</title><title>ACS applied materials & interfaces</title><addtitle>ACS Appl. Mater. Interfaces</addtitle><description>Titanium (Ti) and its alloys with a high mechanical strength and a small diameter can be effectively exploited for minimally invasive dental implantation. Here, we report a multipass caliber-rolled Ti alloy of Ti13Nb13Zr (MPCR-TNZ) with a high mechanical strength and strong fatigue characteristics. For further dental applications, MPCR-TNZ was surface-modified with reduced graphene oxide (RGO) and loaded with osteogenic dexamethasone (Dex) via π–π stacking on the graphitic domain of RGO. The Dex-loaded RGO-MPCR-TNZ (Dex/RGO-MPCR-TNZ) resulted in significantly enhanced growth and differentiation of MC3T3-E1 cells into osteoblasts, which was confirmed by Alizarin red staining, alkaline phosphatase activity test, immunocytochemistry, and real-time PCR. Moreover, we could confirm the feasibility of Dex/RGO-MPCR-TNZ from the implantation test of a prototype of a dental implant to an artificial bone block for clinical dental applications.</description><subject>Alloys - chemistry</subject><subject>Animals</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Dentistry - methods</subject><subject>Dexamethasone - pharmacology</subject><subject>Fluorescent Antibody Technique</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Graphite - chemistry</subject><subject>Mechanical Phenomena</subject><subject>Mice</subject><subject>Microscopy, Atomic Force</subject><subject>Osteoblasts - cytology</subject><subject>Osteoblasts - drug effects</subject><subject>Oxidation-Reduction</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - drug effects</subject><subject>Surface Properties</subject><subject>Titanium - chemistry</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFu1DAQQC0EoqXlyrHyEVXKYmdsb3xcbUtB2gqJlnM0ScZaV06c2olg_55Uu_TGaebw5knzGPskxUqKUn7BNmPvV7oRoEC-YefSKlVUpS7fvu5KnbEPOT8JYaAU-j07K7UVVhs4Z9PDnBy2xO9j551vcfJx4NHx-zlMfsSc-RaDbygVP2MI1PFHzzchxAP_7ac9v6E_2NO0xxwHKnYRuwW5SzjuaSDuYlqIYcLAN-MYTvp8yd45DJk-nuYF-_X19nH7rdj9uPu-3ewKBBBTYdYADmSlXNVVtFbGYNlCo1uolLRGW3BEgIKMsQ1UmhoF1ihhhBWikmu4YJ-P3jHF55nyVPc-txQCDhTnXEtTLRmshhd0dUTbFHNO5Oox-R7ToZaifildH0vXp9LLwdXJPTc9da_4v7QLcH0ElsP6Kc5pWF79n-0vpUeISQ</recordid><startdate>20150513</startdate><enddate>20150513</enddate><creator>Jung, Ho Sang</creator><creator>Lee, Taekyung</creator><creator>Kwon, Il Keun</creator><creator>Kim, Hyoung Seop</creator><creator>Hahn, Sei Kwang</creator><creator>Lee, Chong Soo</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150513</creationdate><title>Surface Modification of Multipass Caliber-Rolled Ti Alloy with Dexamethasone-Loaded Graphene for Dental Applications</title><author>Jung, Ho Sang ; Lee, Taekyung ; Kwon, Il Keun ; Kim, Hyoung Seop ; Hahn, Sei Kwang ; Lee, Chong Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a330t-6733f3184f8d8e7466a2c3b5c384196593fee3a0e669b385eb439640609008173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alloys - chemistry</topic><topic>Animals</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Dentistry - methods</topic><topic>Dexamethasone - pharmacology</topic><topic>Fluorescent Antibody Technique</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Graphite - chemistry</topic><topic>Mechanical Phenomena</topic><topic>Mice</topic><topic>Microscopy, Atomic Force</topic><topic>Osteoblasts - cytology</topic><topic>Osteoblasts - drug effects</topic><topic>Oxidation-Reduction</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - drug effects</topic><topic>Surface Properties</topic><topic>Titanium - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Ho Sang</creatorcontrib><creatorcontrib>Lee, Taekyung</creatorcontrib><creatorcontrib>Kwon, Il Keun</creatorcontrib><creatorcontrib>Kim, Hyoung Seop</creatorcontrib><creatorcontrib>Hahn, Sei Kwang</creatorcontrib><creatorcontrib>Lee, Chong Soo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Ho Sang</au><au>Lee, Taekyung</au><au>Kwon, Il Keun</au><au>Kim, Hyoung Seop</au><au>Hahn, Sei Kwang</au><au>Lee, Chong Soo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surface Modification of Multipass Caliber-Rolled Ti Alloy with Dexamethasone-Loaded Graphene for Dental Applications</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><date>2015-05-13</date><risdate>2015</risdate><volume>7</volume><issue>18</issue><spage>9598</spage><epage>9607</epage><pages>9598-9607</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>Titanium (Ti) and its alloys with a high mechanical strength and a small diameter can be effectively exploited for minimally invasive dental implantation. Here, we report a multipass caliber-rolled Ti alloy of Ti13Nb13Zr (MPCR-TNZ) with a high mechanical strength and strong fatigue characteristics. For further dental applications, MPCR-TNZ was surface-modified with reduced graphene oxide (RGO) and loaded with osteogenic dexamethasone (Dex) via π–π stacking on the graphitic domain of RGO. The Dex-loaded RGO-MPCR-TNZ (Dex/RGO-MPCR-TNZ) resulted in significantly enhanced growth and differentiation of MC3T3-E1 cells into osteoblasts, which was confirmed by Alizarin red staining, alkaline phosphatase activity test, immunocytochemistry, and real-time PCR. 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| subjects | Alloys - chemistry Animals Cell Differentiation - drug effects Cell Line Cell Survival - drug effects Dentistry - methods Dexamethasone - pharmacology Fluorescent Antibody Technique Gene Expression Regulation - drug effects Graphite - chemistry Mechanical Phenomena Mice Microscopy, Atomic Force Osteoblasts - cytology Osteoblasts - drug effects Oxidation-Reduction Stem Cells - cytology Stem Cells - drug effects Surface Properties Titanium - chemistry |
| title | Surface Modification of Multipass Caliber-Rolled Ti Alloy with Dexamethasone-Loaded Graphene for Dental Applications |
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