4-D spatiotemporal analysis of ultrasound contrast agent dispersion for prostate cancer localization: a feasibility study
Currently, nonradical treatment for prostate cancer is hampered by the lack of reliable diagnostics. Contrastultrasound dispersion imaging (CUDI) has recently shown great potential as a prostate cancer imaging technique. CUDI estimates the local dispersion of intravenously injected contrast agents,...
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| Veröffentlicht in: | IEEE transactions on ultrasonics, ferroelectrics, and frequency control ferroelectrics, and frequency control, 2015-05, Vol.62 (5), p.839-851 |
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| container_title | IEEE transactions on ultrasonics, ferroelectrics, and frequency control |
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| creator | Schalk, Stefan G. Demi, Libertario Smeenge, Martijn Mills, David M. Wallace, Kirk D. de la Rosette, Jean J. M. C. H. Wijkstra, Hessel Mischi, Massimo |
| description | Currently, nonradical treatment for prostate cancer is hampered by the lack of reliable diagnostics. Contrastultrasound dispersion imaging (CUDI) has recently shown great potential as a prostate cancer imaging technique. CUDI estimates the local dispersion of intravenously injected contrast agents, imaged by transrectal dynamic contrast-enhanced ultrasound (DCE-US), to detect angiogenic processes related to tumor growth. The best CUDI results have so far been obtained by similarity analysis of the contrast kinetics in neighboring pixels. To date, CUDI has been investigated in 2-D only. In this paper, an implementation of 3-D CUDI based on spatiotemporal similarity analysis of 4-D DCE-US is described. Different from 2-D methods, 3-D CUDI permits analysis of the entire prostate using a single injection of contrast agent. To perform 3-D CUDI, a new strategy was designed to estimate the similarity in the contrast kinetics at each voxel, and data processing steps were adjusted to the characteristics of 4-D DCE-US images. The technical feasibility of 4-D DCE-US in 3-D CUDI was assessed and confirmed. Additionally, in a preliminary validation in two patients, dispersion maps by 3-D CUDI were quantitatively compared with those by 2-D CUDI and with 12-core systematic biopsies with promising results. |
| doi_str_mv | 10.1109/TUFFC.2014.006907 |
| format | Article |
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M. C. H. ; Wijkstra, Hessel ; Mischi, Massimo</creator><creatorcontrib>Schalk, Stefan G. ; Demi, Libertario ; Smeenge, Martijn ; Mills, David M. ; Wallace, Kirk D. ; de la Rosette, Jean J. M. C. H. ; Wijkstra, Hessel ; Mischi, Massimo</creatorcontrib><description>Currently, nonradical treatment for prostate cancer is hampered by the lack of reliable diagnostics. Contrastultrasound dispersion imaging (CUDI) has recently shown great potential as a prostate cancer imaging technique. CUDI estimates the local dispersion of intravenously injected contrast agents, imaged by transrectal dynamic contrast-enhanced ultrasound (DCE-US), to detect angiogenic processes related to tumor growth. The best CUDI results have so far been obtained by similarity analysis of the contrast kinetics in neighboring pixels. To date, CUDI has been investigated in 2-D only. In this paper, an implementation of 3-D CUDI based on spatiotemporal similarity analysis of 4-D DCE-US is described. Different from 2-D methods, 3-D CUDI permits analysis of the entire prostate using a single injection of contrast agent. To perform 3-D CUDI, a new strategy was designed to estimate the similarity in the contrast kinetics at each voxel, and data processing steps were adjusted to the characteristics of 4-D DCE-US images. The technical feasibility of 4-D DCE-US in 3-D CUDI was assessed and confirmed. Additionally, in a preliminary validation in two patients, dispersion maps by 3-D CUDI were quantitatively compared with those by 2-D CUDI and with 12-core systematic biopsies with promising results.</description><identifier>ISSN: 0885-3010</identifier><identifier>EISSN: 1525-8955</identifier><identifier>DOI: 10.1109/TUFFC.2014.006907</identifier><identifier>PMID: 25965678</identifier><identifier>CODEN: ITUCER</identifier><language>eng</language><publisher>United States: IEEE</publisher><subject>Cancer ; Contrast agents ; Contrast Media - pharmacokinetics ; Dispersion ; Dispersions ; Estimates ; Feasibility Studies ; Humans ; Imaging ; Imaging, Three-Dimensional - methods ; Kernel ; Male ; Prostate ; Prostate - diagnostic imaging ; Prostate cancer ; Prostatic Neoplasms - diagnostic imaging ; Reproducibility of Results ; Similarity ; Spatio-Temporal Analysis ; Spatiotemporal phenomena ; Speckle ; Three dimensional ; Ultrasonic imaging ; Ultrasonography ; Ultrasound ; Wiener filters</subject><ispartof>IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2015-05, Vol.62 (5), p.839-851</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) May 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-fc9232f3f40fa9c745e1f706524a75198941b868b2189bcc295a90903854fc033</citedby><cites>FETCH-LOGICAL-c458t-fc9232f3f40fa9c745e1f706524a75198941b868b2189bcc295a90903854fc033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/7103524$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,776,780,792,27901,27902,54733</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/7103524$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25965678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schalk, Stefan G.</creatorcontrib><creatorcontrib>Demi, Libertario</creatorcontrib><creatorcontrib>Smeenge, Martijn</creatorcontrib><creatorcontrib>Mills, David M.</creatorcontrib><creatorcontrib>Wallace, Kirk D.</creatorcontrib><creatorcontrib>de la Rosette, Jean J. M. C. H.</creatorcontrib><creatorcontrib>Wijkstra, Hessel</creatorcontrib><creatorcontrib>Mischi, Massimo</creatorcontrib><title>4-D spatiotemporal analysis of ultrasound contrast agent dispersion for prostate cancer localization: a feasibility study</title><title>IEEE transactions on ultrasonics, ferroelectrics, and frequency control</title><addtitle>T-UFFC</addtitle><addtitle>IEEE Trans Ultrason Ferroelectr Freq Control</addtitle><description>Currently, nonradical treatment for prostate cancer is hampered by the lack of reliable diagnostics. Contrastultrasound dispersion imaging (CUDI) has recently shown great potential as a prostate cancer imaging technique. CUDI estimates the local dispersion of intravenously injected contrast agents, imaged by transrectal dynamic contrast-enhanced ultrasound (DCE-US), to detect angiogenic processes related to tumor growth. The best CUDI results have so far been obtained by similarity analysis of the contrast kinetics in neighboring pixels. To date, CUDI has been investigated in 2-D only. In this paper, an implementation of 3-D CUDI based on spatiotemporal similarity analysis of 4-D DCE-US is described. Different from 2-D methods, 3-D CUDI permits analysis of the entire prostate using a single injection of contrast agent. To perform 3-D CUDI, a new strategy was designed to estimate the similarity in the contrast kinetics at each voxel, and data processing steps were adjusted to the characteristics of 4-D DCE-US images. The technical feasibility of 4-D DCE-US in 3-D CUDI was assessed and confirmed. Additionally, in a preliminary validation in two patients, dispersion maps by 3-D CUDI were quantitatively compared with those by 2-D CUDI and with 12-core systematic biopsies with promising results.</description><subject>Cancer</subject><subject>Contrast agents</subject><subject>Contrast Media - pharmacokinetics</subject><subject>Dispersion</subject><subject>Dispersions</subject><subject>Estimates</subject><subject>Feasibility Studies</subject><subject>Humans</subject><subject>Imaging</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Kernel</subject><subject>Male</subject><subject>Prostate</subject><subject>Prostate - diagnostic imaging</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - diagnostic imaging</subject><subject>Reproducibility of Results</subject><subject>Similarity</subject><subject>Spatio-Temporal Analysis</subject><subject>Spatiotemporal phenomena</subject><subject>Speckle</subject><subject>Three dimensional</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><subject>Ultrasound</subject><subject>Wiener filters</subject><issn>0885-3010</issn><issn>1525-8955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAURi1ERYfCAyAkZIkNmwzXf7HNrhoYWqkSm3YdOR4bufLEwXYW4elJOqULNnTlK_nco6vvQ-gdgS0hoD_f3u33uy0FwrcArQb5Am2IoKJRWoiXaANKiYYBgXP0upR7WECu6St0ToVuRSvVBs28-YrLaGpI1R3HlE3EZjBxLqHg5PEUazYlTcMB2zSsc8XmpxsqPoQyulxCGrBPGY85lWqqw9YM1mUckzUx_F7FwxdssHemhD7EUGdc6nSY36Azb2Jxbx_fC3S3_3a7u2pufny_3l3eNJYLVRtvNWXUM8_BG20lF454Ca2g3EhBtNKc9KpVPSVK99ZSLYwGDUwJ7i0wdoE-nbzLhb8mV2p3DMW6GM3g0lQ6oogmTLKW_h-VoKUQwJ-Btgq0UC3TC_rxH_Q-TXnJ-EFING-BrEJyouwSZMnOd2MOR5PnjkC3tt09tN2tbXentpedD4_mqT-6w9PG33oX4P0JCM65p29JgC3xsT_RAa3Q</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Schalk, Stefan G.</creator><creator>Demi, Libertario</creator><creator>Smeenge, Martijn</creator><creator>Mills, David M.</creator><creator>Wallace, Kirk D.</creator><creator>de la Rosette, Jean J. M. C. H.</creator><creator>Wijkstra, Hessel</creator><creator>Mischi, Massimo</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. (IEEE)</general><scope>97E</scope><scope>RIA</scope><scope>RIE</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>L7M</scope><scope>7X8</scope><scope>7QO</scope><scope>P64</scope></search><sort><creationdate>201505</creationdate><title>4-D spatiotemporal analysis of ultrasound contrast agent dispersion for prostate cancer localization: a feasibility study</title><author>Schalk, Stefan G. ; Demi, Libertario ; Smeenge, Martijn ; Mills, David M. ; Wallace, Kirk D. ; de la Rosette, Jean J. M. C. H. ; Wijkstra, Hessel ; Mischi, Massimo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-fc9232f3f40fa9c745e1f706524a75198941b868b2189bcc295a90903854fc033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Cancer</topic><topic>Contrast agents</topic><topic>Contrast Media - pharmacokinetics</topic><topic>Dispersion</topic><topic>Dispersions</topic><topic>Estimates</topic><topic>Feasibility Studies</topic><topic>Humans</topic><topic>Imaging</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Kernel</topic><topic>Male</topic><topic>Prostate</topic><topic>Prostate - diagnostic imaging</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - diagnostic imaging</topic><topic>Reproducibility of Results</topic><topic>Similarity</topic><topic>Spatio-Temporal Analysis</topic><topic>Spatiotemporal phenomena</topic><topic>Speckle</topic><topic>Three dimensional</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><topic>Ultrasound</topic><topic>Wiener filters</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schalk, Stefan G.</creatorcontrib><creatorcontrib>Demi, Libertario</creatorcontrib><creatorcontrib>Smeenge, Martijn</creatorcontrib><creatorcontrib>Mills, David M.</creatorcontrib><creatorcontrib>Wallace, Kirk D.</creatorcontrib><creatorcontrib>de la Rosette, Jean J. 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H.</creatorcontrib><creatorcontrib>Wijkstra, Hessel</creatorcontrib><creatorcontrib>Mischi, Massimo</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 2005-present</collection><collection>IEEE All-Society Periodicals Package (ASPP) 1998-Present</collection><collection>IEEE Electronic Library (IEL)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>IEEE transactions on ultrasonics, ferroelectrics, and frequency control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Schalk, Stefan G.</au><au>Demi, Libertario</au><au>Smeenge, Martijn</au><au>Mills, David M.</au><au>Wallace, Kirk D.</au><au>de la Rosette, Jean J. M. C. H.</au><au>Wijkstra, Hessel</au><au>Mischi, Massimo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>4-D spatiotemporal analysis of ultrasound contrast agent dispersion for prostate cancer localization: a feasibility study</atitle><jtitle>IEEE transactions on ultrasonics, ferroelectrics, and frequency control</jtitle><stitle>T-UFFC</stitle><addtitle>IEEE Trans Ultrason Ferroelectr Freq Control</addtitle><date>2015-05</date><risdate>2015</risdate><volume>62</volume><issue>5</issue><spage>839</spage><epage>851</epage><pages>839-851</pages><issn>0885-3010</issn><eissn>1525-8955</eissn><coden>ITUCER</coden><abstract>Currently, nonradical treatment for prostate cancer is hampered by the lack of reliable diagnostics. Contrastultrasound dispersion imaging (CUDI) has recently shown great potential as a prostate cancer imaging technique. 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| subjects | Cancer Contrast agents Contrast Media - pharmacokinetics Dispersion Dispersions Estimates Feasibility Studies Humans Imaging Imaging, Three-Dimensional - methods Kernel Male Prostate Prostate - diagnostic imaging Prostate cancer Prostatic Neoplasms - diagnostic imaging Reproducibility of Results Similarity Spatio-Temporal Analysis Spatiotemporal phenomena Speckle Three dimensional Ultrasonic imaging Ultrasonography Ultrasound Wiener filters |
| title | 4-D spatiotemporal analysis of ultrasound contrast agent dispersion for prostate cancer localization: a feasibility study |
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