Measurement of low amounts of amorphous content in hydrophobic active pharmaceutical ingredients with dynamic organic vapor sorption

[Display omitted] •Organic solvent screening for receiving a high affinity to hydrophobic ciclesonide.•Determination of optimal vapor value (p/p0) for isopropanol.•Investigation of temperature robustness (DoE) and influence of small particle size (

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2015-05, Vol.92, p.102-111
Hauptverfasser:	Müller, Thorsten, Schiewe, Jörg, Smal, Rüdiger, Weiler, Claudius, Wolkenhauer, Markus, Steckel, Hartwig
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Propanol - chemistry Albuterol - administration & dosage Albuterol - chemistry Chemistry, Pharmaceutical - methods Ciclesonide Crystallization Drug Delivery Systems Dry Powder Inhalers Glass transition Gordon–Taylor Humidity Hydrophobic and Hydrophilic Interactions Isopropanol Organic solvent screening Particle Size Pilot Projects Powders Pregnenediones - administration & dosage Pregnenediones - chemistry Salbutamol sulfate Solvents - chemistry Transition Temperature Water - chemistry
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Beschreibung
Zusammenfassung:	[Display omitted] •Organic solvent screening for receiving a high affinity to hydrophobic ciclesonide.•Determination of optimal vapor value (p/p0) for isopropanol.•Investigation of temperature robustness (DoE) and influence of small particle size (
ISSN:	0939-6411 1873-3441
DOI:	10.1016/j.ejpb.2015.02.030