Impact of Nanosizing on Solubility and Dissolution Rate of Poorly Soluble Pharmaceuticals

The quantitative determination of solubility and the initial dissolution rate enhancement of crystalline nanoparticles were critically investigated using a separation-based approach (ultracentrifugation and filtration). Four poorly soluble model compounds (griseofulvin, celecoxib, compound-X, and fe...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2015-06, Vol.104 (6), p.2094-2102
Hauptverfasser:	Murdande, Sharad B., Shah, Dhaval A., Dave, Rutesh H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Celecoxib - chemistry dissolution rate Fenofibrate - chemistry Griseofulvin - chemistry Kinetics nanoparticles Nanoparticles - chemistry nanosuspension Nanotechnology Pharmaceutical Preparations - chemistry Solubility Thermodynamics Transition Temperature
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