Topoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy

Although a number of drugs currently in use for the treatment of human cancers act by stimulating topoisomerase II-mediated DNA breakage, little is known regarding interactions between these agents and the enzyme. To further define the mechanism of drug action, interactions between ellipticine (an i...

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Veröffentlicht in:	The Journal of biological chemistry 1995-06, Vol.270 (25), p.14998-15004
Hauptverfasser:	Froelich-Ammon, S J, Patchan, M W, Osheroff, N, Thompson, R B
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence DNA - chemistry DNA - metabolism DNA Damage DNA Topoisomerases, Type II - chemistry DNA Topoisomerases, Type II - isolation & purification DNA Topoisomerases, Type II - metabolism Ellipticines - chemistry Ellipticines - metabolism Ellipticines - toxicity Hydrogen-Ion Concentration Kinetics Models, Structural Molecular Sequence Data Oligodeoxyribonucleotides - metabolism Protein Binding Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - enzymology Spectrophotometry
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