Tolcapone, an inhibitor of catechol O-methyltransferase, counteracts memory deficits caused by bilateral cholinotoxin lesions of the basal nuclei of Meynert
Repeated administration of tolcapone, an inhibitor of catechol-O-methyltransferase, was able to partially restore the memory deficits caused by bilateral cholinotoxin (AF64A) lesions in the basal magnocellular nuclei of Meynert. The 2-week tolcapone treatment (3 mg kg, once a day) was started 24 h b...
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| Veröffentlicht in: | Neuroreport 1995-05, Vol.6 (8), p.1219-1222 |
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| container_title | Neuroreport |
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| creator | Khromova, Irina Rauhala, Pekka Zolotov, Nikolai Mannisto, Pekka T |
| description | Repeated administration of tolcapone, an inhibitor of catechol-O-methyltransferase, was able to partially restore the memory deficits caused by bilateral cholinotoxin (AF64A) lesions in the basal magnocellular nuclei of Meynert. The 2-week tolcapone treatment (3 mg kg, once a day) was started 24 h before toxin infusion and the last injection was given 24 h before the first avoidance test. The beneficial action of tolcapone may be related to anti-oxidant properties of nitrocatechols. |
| doi_str_mv | 10.1097/00001756-199505300-00036 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0959-4965 |
| ispartof | Neuroreport, 1995-05, Vol.6 (8), p.1219-1222 |
| issn | 0959-4965 1473-558X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16808206 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Avoidance Learning - drug effects Benzophenones - pharmacology Catechol O-Methyltransferase Inhibitors Male Memory - drug effects Memory Disorders - chemically induced Nitrophenols Rats Rats, Wistar Substantia Innominata - drug effects Time Factors Tolcapone |
| title | Tolcapone, an inhibitor of catechol O-methyltransferase, counteracts memory deficits caused by bilateral cholinotoxin lesions of the basal nuclei of Meynert |
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