Mode of action of bullatacin: A potent antitumor and pesticidal Annonaceous acetogenin
Bullatacin, a compound isolated from plants of the Annonaceae, and its analogues show in vivo potential as antitumor agents based on their efficacy in normal mice bearing L1210 murine leukemia and athymic mice bearing A2780 conventional ovarian cancer xenografts. These compounds also have interestin...
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| Veröffentlicht in: | Life sciences (1973) 1993, Vol.53 (14), p.1113-1120 |
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| container_title | Life sciences (1973) |
| container_volume | 53 |
| creator | Ahammadsahib, K.I. Hollingworth, R.M. McGovren, J.P. Hui, Y.-H McLaughlin, J.L. |
| description | Bullatacin, a compound isolated from plants of the
Annonaceae, and its analogues show
in vivo potential as antitumor agents based on their efficacy in normal mice bearing L1210 murine leukemia and athymic mice bearing A2780 conventional ovarian cancer xenografts. These compounds also have interesting potential as insecticides and inhibit respiration in insect-derived Sf9 cells with high potency. Their toxicity in both cases probably arises from their strong inhibition of mitochondrial electron transport with a specific action at complex I. |
| doi_str_mv | 10.1016/0024-3205(93)90547-G |
| format | Article |
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Annonaceae, and its analogues show
in vivo potential as antitumor agents based on their efficacy in normal mice bearing L1210 murine leukemia and athymic mice bearing A2780 conventional ovarian cancer xenografts. These compounds also have interesting potential as insecticides and inhibit respiration in insect-derived Sf9 cells with high potency. Their toxicity in both cases probably arises from their strong inhibition of mitochondrial electron transport with a specific action at complex I.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(93)90547-G</identifier><identifier>PMID: 8371627</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Antineoplastic agents ; Antineoplastic Agents, Phytogenic - pharmacology ; Biological and medical sciences ; Cattle ; Chymotrypsin - metabolism ; Furans - pharmacology ; General aspects ; In Vitro Techniques ; Insecticides - pharmacology ; Male ; Medical sciences ; Mice ; Mitochondria - drug effects ; Moths ; NAD(P)H Dehydrogenase (Quinone) - drug effects ; Oxygen Consumption - drug effects ; Pharmacology. Drug treatments ; Plants ; Rats ; Rats, Sprague-Dawley ; Stereoisomerism</subject><ispartof>Life sciences (1973), 1993, Vol.53 (14), p.1113-1120</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-9c3855af9e8aa3c371424fa3fcd44181c39b9c93d91e145a5574da7abf16e92d3</citedby><cites>FETCH-LOGICAL-c483t-9c3855af9e8aa3c371424fa3fcd44181c39b9c93d91e145a5574da7abf16e92d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(93)90547-G$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3801988$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8371627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahammadsahib, K.I.</creatorcontrib><creatorcontrib>Hollingworth, R.M.</creatorcontrib><creatorcontrib>McGovren, J.P.</creatorcontrib><creatorcontrib>Hui, Y.-H</creatorcontrib><creatorcontrib>McLaughlin, J.L.</creatorcontrib><title>Mode of action of bullatacin: A potent antitumor and pesticidal Annonaceous acetogenin</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Bullatacin, a compound isolated from plants of the
Annonaceae, and its analogues show
in vivo potential as antitumor agents based on their efficacy in normal mice bearing L1210 murine leukemia and athymic mice bearing A2780 conventional ovarian cancer xenografts. These compounds also have interesting potential as insecticides and inhibit respiration in insect-derived Sf9 cells with high potency. Their toxicity in both cases probably arises from their strong inhibition of mitochondrial electron transport with a specific action at complex I.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Chymotrypsin - metabolism</subject><subject>Furans - pharmacology</subject><subject>General aspects</subject><subject>In Vitro Techniques</subject><subject>Insecticides - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mitochondria - drug effects</subject><subject>Moths</subject><subject>NAD(P)H Dehydrogenase (Quinone) - drug effects</subject><subject>Oxygen Consumption - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Stereoisomerism</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGKFDEQhoMo67j6Bgp9ENFDa9JJdycehGHZHYUVL-o11FSqJdKTjEla8O1NO8McPaWgvvr58zH2XPC3govhHeedamXH-9dGvjG8V2O7e8A2Qo-m5YMUD9nmgjxmT3L-yTnv-1FesSstRzF044Z9_xwdNXFqAIuPYZ32yzxDAfThfbNtjrFQKA2E4styiKlOrjlSLh69g7nZhhADIMUl1wwq8QcFH56yRxPMmZ6d32v27e72683H9v7L7tPN9r5FpWVpDUrd9zAZ0gASaynVqQnkhE4poQVKszdopDOChOqhtlcORthPYiDTOXnNXp1yjyn-Wmore_AZqX4grI2sGDTXousrqE4gpphzoskekz9A-mMFt6tOu7qyqytrpP2n0-7q2Ytz_rI_kLscnf3V_cvzHjLCPCUI6PMFk5oLo3XFPpwwqi5-e0o2o6eA5HwiLNZF__8efwEP4ZEO</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Ahammadsahib, K.I.</creator><creator>Hollingworth, R.M.</creator><creator>McGovren, J.P.</creator><creator>Hui, Y.-H</creator><creator>McLaughlin, J.L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope></search><sort><creationdate>1993</creationdate><title>Mode of action of bullatacin: A potent antitumor and pesticidal Annonaceous acetogenin</title><author>Ahammadsahib, K.I. ; Hollingworth, R.M. ; McGovren, J.P. ; Hui, Y.-H ; McLaughlin, J.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-9c3855af9e8aa3c371424fa3fcd44181c39b9c93d91e145a5574da7abf16e92d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Chymotrypsin - metabolism</topic><topic>Furans - pharmacology</topic><topic>General aspects</topic><topic>In Vitro Techniques</topic><topic>Insecticides - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mitochondria - drug effects</topic><topic>Moths</topic><topic>NAD(P)H Dehydrogenase (Quinone) - drug effects</topic><topic>Oxygen Consumption - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahammadsahib, K.I.</creatorcontrib><creatorcontrib>Hollingworth, R.M.</creatorcontrib><creatorcontrib>McGovren, J.P.</creatorcontrib><creatorcontrib>Hui, Y.-H</creatorcontrib><creatorcontrib>McLaughlin, J.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahammadsahib, K.I.</au><au>Hollingworth, R.M.</au><au>McGovren, J.P.</au><au>Hui, Y.-H</au><au>McLaughlin, J.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mode of action of bullatacin: A potent antitumor and pesticidal Annonaceous acetogenin</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1993</date><risdate>1993</risdate><volume>53</volume><issue>14</issue><spage>1113</spage><epage>1120</epage><pages>1113-1120</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>Bullatacin, a compound isolated from plants of the
Annonaceae, and its analogues show
in vivo potential as antitumor agents based on their efficacy in normal mice bearing L1210 murine leukemia and athymic mice bearing A2780 conventional ovarian cancer xenografts. These compounds also have interesting potential as insecticides and inhibit respiration in insect-derived Sf9 cells with high potency. Their toxicity in both cases probably arises from their strong inhibition of mitochondrial electron transport with a specific action at complex I.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>8371627</pmid><doi>10.1016/0024-3205(93)90547-G</doi><tpages>8</tpages></addata></record> |
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| ispartof | Life sciences (1973), 1993, Vol.53 (14), p.1113-1120 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Cattle Chymotrypsin - metabolism Furans - pharmacology General aspects In Vitro Techniques Insecticides - pharmacology Male Medical sciences Mice Mitochondria - drug effects Moths NAD(P)H Dehydrogenase (Quinone) - drug effects Oxygen Consumption - drug effects Pharmacology. Drug treatments Plants Rats Rats, Sprague-Dawley Stereoisomerism |
| title | Mode of action of bullatacin: A potent antitumor and pesticidal Annonaceous acetogenin |
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