Bioconcentration of 5,5',6-trichlorobiphenyl and pentachlorophenol in the Midge, Chironomus riparius, as measured by a pharmacokinetic model
Midges were exposed to carbon-14 labelled 5,5',6-trichlorobiphenyl (TCB) and pentachlorophenol (PCP) at nominal concentrations of 2 and 9 ug per litre, respectively for a 16 h static uptake phase. Depuration was measured over 45 h in a flowthrough system. A 2 compartment pharmacokinetic model w...
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| Veröffentlicht in: | Archives of environmental contamination and toxicology 1994-02, Vol.26 (2), p.251-256 |
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| container_title | Archives of environmental contamination and toxicology |
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| creator | LYDY, M. J HAYTON, W. L STAUBUS, A. E FISHER, S. W |
| description | Midges were exposed to carbon-14 labelled 5,5',6-trichlorobiphenyl (TCB) and pentachlorophenol (PCP) at nominal concentrations of 2 and 9 ug per litre, respectively for a 16 h static uptake phase. Depuration was measured over 45 h in a flowthrough system. A 2 compartment pharmacokinetic model was developed to describe the uptake and elimination of both compounds. The uptake clearances were 330 ml per g midge.h for TCB and 55 ml per g midge.h for PCP. The measured bioconcentration factors were 35,900 and 458 for TCB and PCP, which were similar to values of 19, 055 and 758, respectively, obtained from the octanol water partition coefficients. |
| doi_str_mv | 10.1007/BF00224812 |
| format | Article |
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The measured bioconcentration factors were 35,900 and 458 for TCB and PCP, which were similar to values of 19, 055 and 758, respectively, obtained from the octanol water partition coefficients.</description><identifier>ISSN: 0090-4341</identifier><identifier>EISSN: 1432-0703</identifier><identifier>DOI: 10.1007/BF00224812</identifier><identifier>CODEN: AECTCV</identifier><language>eng</language><publisher>Heidelberg: Springer-Verlag</publisher><subject>Animal, plant and microbial ecology ; Applied ecology ; Biological and medical sciences ; chironomidae ; Chironomus riparius ; Diptera ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on protozoa and invertebrates ; Freshwater ; Fundamental and applied biological sciences. 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The measured bioconcentration factors were 35,900 and 458 for TCB and PCP, which were similar to values of 19, 055 and 758, respectively, obtained from the octanol water partition coefficients.</description><subject>Animal, plant and microbial ecology</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>chironomidae</subject><subject>Chironomus riparius</subject><subject>Diptera</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on protozoa and invertebrates</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. 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E</au><au>FISHER, S. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioconcentration of 5,5',6-trichlorobiphenyl and pentachlorophenol in the Midge, Chironomus riparius, as measured by a pharmacokinetic model</atitle><jtitle>Archives of environmental contamination and toxicology</jtitle><date>1994-02-01</date><risdate>1994</risdate><volume>26</volume><issue>2</issue><spage>251</spage><epage>256</epage><pages>251-256</pages><issn>0090-4341</issn><eissn>1432-0703</eissn><coden>AECTCV</coden><abstract>Midges were exposed to carbon-14 labelled 5,5',6-trichlorobiphenyl (TCB) and pentachlorophenol (PCP) at nominal concentrations of 2 and 9 ug per litre, respectively for a 16 h static uptake phase. Depuration was measured over 45 h in a flowthrough system. A 2 compartment pharmacokinetic model was developed to describe the uptake and elimination of both compounds. The uptake clearances were 330 ml per g midge.h for TCB and 55 ml per g midge.h for PCP. 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| ispartof | Archives of environmental contamination and toxicology, 1994-02, Vol.26 (2), p.251-256 |
| issn | 0090-4341 1432-0703 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Animal, plant and microbial ecology Applied ecology Biological and medical sciences chironomidae Chironomus riparius Diptera Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on protozoa and invertebrates Freshwater Fundamental and applied biological sciences. Psychology |
| title | Bioconcentration of 5,5',6-trichlorobiphenyl and pentachlorophenol in the Midge, Chironomus riparius, as measured by a pharmacokinetic model |
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