Cholinergic lesions by 192 IgG-saporin and short-term recognition memory: Role of the septohippocampal projection

Two experiments examined the effects of cholinergic basal forebrain lesions by intraventricular and intrahippocampal infusions of the immunotoxin 192 IgG-saporin on recognition memory in an operant delayed-non-matching-to-position task in rats. Intraventricular infusions produced extensive reduction...

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Veröffentlicht in:	Neuroscience 1995-05, Vol.66 (1), p.101-114
Hauptverfasser:	Steckler, T., Keith, A.B., Wiley, R.G., Sahgal, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - toxicity Autonomic Nervous System Diseases - chemically induced Autonomic Nervous System Diseases - pathology Behavioral psychophysiology Biological and medical sciences Choline O-Acetyltransferase - metabolism Cholinergic Agents - administration & dosage Cholinergic Agents - toxicity Cognition Disorders - chemically induced Conditioning, Operant - drug effects Fundamental and applied biological sciences. Psychology Glutamate Decarboxylase - metabolism Hippocampus - cytology Hippocampus - enzymology Hippocampus - physiology Immunotoxins - administration & dosage Immunotoxins - toxicity Injections Injections, Intraventricular Male Memory Disorders - chemically induced N-Glycosyl Hydrolases Neural Pathways - cytology Neural Pathways - physiology Neurotransmission and behavior Parasympathetic Nervous System - physiology Prosencephalon - cytology Prosencephalon - enzymology Prosencephalon - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Ribosome Inactivating Proteins, Type 1 Saporins Scopolamine - pharmacology
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