Diffusion-weighted magnetic resonance for assessing ileal Crohn's disease activity
Endoscopy and imaging objectively assess Crohn's disease (CD) activity. Magnetic resonance enterography (MRE) uses no ionizing radiation, carries no significant morbidity, and is highly sensitive in revealing soft tissues inflammation. Diffusion-weighted imaging can distinguish intestinal infla...
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| Veröffentlicht in: | Inflammatory bowel diseases 2014-09, Vol.20 (9), p.1575-1583 |
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| container_title | Inflammatory bowel diseases |
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| creator | Caruso, Antonino DʼIncà, Renata Scarpa, Marco Manfrin, Paolo Rudatis, Massimo Pozza, Anna Angriman, Imerio Buda, Andrea Sturniolo, Giacomo Carlo Lacognata, Carmelo |
| description | Endoscopy and imaging objectively assess Crohn's disease (CD) activity. Magnetic resonance enterography (MRE) uses no ionizing radiation, carries no significant morbidity, and is highly sensitive in revealing soft tissues inflammation. Diffusion-weighted imaging can distinguish intestinal inflammation from a lower diffusion of water molecules giving rise to a reduced apparent diffusion coefficient. The magnetic resonance index of activity score and, more recently, the Clermont score were recently developed for staging CD activity. The aim of this study was to compare the MRE scores and the Simple Endoscopic Score for CD in identifying ileal CD activity.
Fifty-five patients with ileal and ileocolonic CD were consecutively enrolled between June 2012 and June 2013. All patients underwent clinical examination, biochemical tests, MRE, and colonoscopy to assess disease activity.
MRE assessed active ileal disease in 31 patients (56.3%). The Clermont score significantly correlated with the magnetic resonance index of activity score (r = 0.91; P < 0.0001) and the Simple Endoscopic Score for CD (r = 0.76; P < 0.0001). The apparent diffusion coefficient correlated with the Simple Endoscopic Score for CD (r = -0.63; P < 0.0001) especially in unoperated patients.
The Clermont score and the apparent diffusion coefficient value can stage ileal CD, avoiding the need to use contrast agents. |
| doi_str_mv | 10.1097/MIB.0000000000000128 |
| format | Article |
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Fifty-five patients with ileal and ileocolonic CD were consecutively enrolled between June 2012 and June 2013. All patients underwent clinical examination, biochemical tests, MRE, and colonoscopy to assess disease activity.
MRE assessed active ileal disease in 31 patients (56.3%). The Clermont score significantly correlated with the magnetic resonance index of activity score (r = 0.91; P < 0.0001) and the Simple Endoscopic Score for CD (r = 0.76; P < 0.0001). The apparent diffusion coefficient correlated with the Simple Endoscopic Score for CD (r = -0.63; P < 0.0001) especially in unoperated patients.
The Clermont score and the apparent diffusion coefficient value can stage ileal CD, avoiding the need to use contrast agents.</description><identifier>ISSN: 1078-0998</identifier><identifier>EISSN: 1536-4844</identifier><identifier>DOI: 10.1097/MIB.0000000000000128</identifier><identifier>PMID: 25025715</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Colonoscopy ; Contrast Media ; Crohn Disease - pathology ; Diffusion Magnetic Resonance Imaging - methods ; Female ; Follow-Up Studies ; Humans ; Ileitis - diagnosis ; Ileum - pathology ; Image Processing, Computer-Assisted ; Inflammation - diagnosis ; Male ; Middle Aged ; Prognosis ; Retrospective Studies</subject><ispartof>Inflammatory bowel diseases, 2014-09, Vol.20 (9), p.1575-1583</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-158d5284da7a42731928fbe7755b8ccf5fbf26023f6eac522a703e649eac85f63</citedby><cites>FETCH-LOGICAL-c340t-158d5284da7a42731928fbe7755b8ccf5fbf26023f6eac522a703e649eac85f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25025715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caruso, Antonino</creatorcontrib><creatorcontrib>DʼIncà, Renata</creatorcontrib><creatorcontrib>Scarpa, Marco</creatorcontrib><creatorcontrib>Manfrin, Paolo</creatorcontrib><creatorcontrib>Rudatis, Massimo</creatorcontrib><creatorcontrib>Pozza, Anna</creatorcontrib><creatorcontrib>Angriman, Imerio</creatorcontrib><creatorcontrib>Buda, Andrea</creatorcontrib><creatorcontrib>Sturniolo, Giacomo Carlo</creatorcontrib><creatorcontrib>Lacognata, Carmelo</creatorcontrib><title>Diffusion-weighted magnetic resonance for assessing ileal Crohn's disease activity</title><title>Inflammatory bowel diseases</title><addtitle>Inflamm Bowel Dis</addtitle><description>Endoscopy and imaging objectively assess Crohn's disease (CD) activity. Magnetic resonance enterography (MRE) uses no ionizing radiation, carries no significant morbidity, and is highly sensitive in revealing soft tissues inflammation. Diffusion-weighted imaging can distinguish intestinal inflammation from a lower diffusion of water molecules giving rise to a reduced apparent diffusion coefficient. The magnetic resonance index of activity score and, more recently, the Clermont score were recently developed for staging CD activity. The aim of this study was to compare the MRE scores and the Simple Endoscopic Score for CD in identifying ileal CD activity.
Fifty-five patients with ileal and ileocolonic CD were consecutively enrolled between June 2012 and June 2013. All patients underwent clinical examination, biochemical tests, MRE, and colonoscopy to assess disease activity.
MRE assessed active ileal disease in 31 patients (56.3%). The Clermont score significantly correlated with the magnetic resonance index of activity score (r = 0.91; P < 0.0001) and the Simple Endoscopic Score for CD (r = 0.76; P < 0.0001). The apparent diffusion coefficient correlated with the Simple Endoscopic Score for CD (r = -0.63; P < 0.0001) especially in unoperated patients.
The Clermont score and the apparent diffusion coefficient value can stage ileal CD, avoiding the need to use contrast agents.</description><subject>Adult</subject><subject>Colonoscopy</subject><subject>Contrast Media</subject><subject>Crohn Disease - pathology</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Ileitis - diagnosis</subject><subject>Ileum - pathology</subject><subject>Image Processing, Computer-Assisted</subject><subject>Inflammation - diagnosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><issn>1078-0998</issn><issn>1536-4844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo7rr6D0R600vXJE2a9KjrJ6wIoueSppPdSD_WTKvsv7eyq4gXZw4zA-87LzyEHDM6ZTRT5w_3l1P6uxjXO2TMZJLGQguxO-xU6ZhmmR6RA8RXSvnQ2T4ZcUm5VEyOydOVd65H3zbxB_jFsoMyqs2igc7bKAC2jWksRK4NkUEERN8sIl-BqaJZaJfNKUalRzAIkbGdf_fd-pDsOVMhHG3nhLzcXD_P7uL54-397GIe20TQLmZSl5JrURplBFcJy7h2BSglZaGtddIVjqeUJy4FYyXnRtEEUpENl5YuTSbkbPN3Fdq3HrDLa48Wqso00PaYs1RTITMl5P9SKRNFh2g9SMVGakOLGMDlq-BrE9Y5o_kX-HwAn_8FP9hOtgl9UUP5Y_omnXwCQXN92A</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Caruso, Antonino</creator><creator>DʼIncà, Renata</creator><creator>Scarpa, Marco</creator><creator>Manfrin, Paolo</creator><creator>Rudatis, Massimo</creator><creator>Pozza, Anna</creator><creator>Angriman, Imerio</creator><creator>Buda, Andrea</creator><creator>Sturniolo, Giacomo Carlo</creator><creator>Lacognata, Carmelo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20140901</creationdate><title>Diffusion-weighted magnetic resonance for assessing ileal Crohn's disease activity</title><author>Caruso, Antonino ; DʼIncà, Renata ; Scarpa, Marco ; Manfrin, Paolo ; Rudatis, Massimo ; Pozza, Anna ; Angriman, Imerio ; Buda, Andrea ; Sturniolo, Giacomo Carlo ; Lacognata, Carmelo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-158d5284da7a42731928fbe7755b8ccf5fbf26023f6eac522a703e649eac85f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Colonoscopy</topic><topic>Contrast Media</topic><topic>Crohn Disease - pathology</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Ileitis - diagnosis</topic><topic>Ileum - pathology</topic><topic>Image Processing, Computer-Assisted</topic><topic>Inflammation - diagnosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caruso, Antonino</creatorcontrib><creatorcontrib>DʼIncà, Renata</creatorcontrib><creatorcontrib>Scarpa, Marco</creatorcontrib><creatorcontrib>Manfrin, Paolo</creatorcontrib><creatorcontrib>Rudatis, Massimo</creatorcontrib><creatorcontrib>Pozza, Anna</creatorcontrib><creatorcontrib>Angriman, Imerio</creatorcontrib><creatorcontrib>Buda, Andrea</creatorcontrib><creatorcontrib>Sturniolo, Giacomo Carlo</creatorcontrib><creatorcontrib>Lacognata, Carmelo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Inflammatory bowel diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caruso, Antonino</au><au>DʼIncà, Renata</au><au>Scarpa, Marco</au><au>Manfrin, Paolo</au><au>Rudatis, Massimo</au><au>Pozza, Anna</au><au>Angriman, Imerio</au><au>Buda, Andrea</au><au>Sturniolo, Giacomo Carlo</au><au>Lacognata, Carmelo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diffusion-weighted magnetic resonance for assessing ileal Crohn's disease activity</atitle><jtitle>Inflammatory bowel diseases</jtitle><addtitle>Inflamm Bowel Dis</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>20</volume><issue>9</issue><spage>1575</spage><epage>1583</epage><pages>1575-1583</pages><issn>1078-0998</issn><eissn>1536-4844</eissn><abstract>Endoscopy and imaging objectively assess Crohn's disease (CD) activity. Magnetic resonance enterography (MRE) uses no ionizing radiation, carries no significant morbidity, and is highly sensitive in revealing soft tissues inflammation. Diffusion-weighted imaging can distinguish intestinal inflammation from a lower diffusion of water molecules giving rise to a reduced apparent diffusion coefficient. The magnetic resonance index of activity score and, more recently, the Clermont score were recently developed for staging CD activity. The aim of this study was to compare the MRE scores and the Simple Endoscopic Score for CD in identifying ileal CD activity.
Fifty-five patients with ileal and ileocolonic CD were consecutively enrolled between June 2012 and June 2013. All patients underwent clinical examination, biochemical tests, MRE, and colonoscopy to assess disease activity.
MRE assessed active ileal disease in 31 patients (56.3%). The Clermont score significantly correlated with the magnetic resonance index of activity score (r = 0.91; P < 0.0001) and the Simple Endoscopic Score for CD (r = 0.76; P < 0.0001). The apparent diffusion coefficient correlated with the Simple Endoscopic Score for CD (r = -0.63; P < 0.0001) especially in unoperated patients.
The Clermont score and the apparent diffusion coefficient value can stage ileal CD, avoiding the need to use contrast agents.</abstract><cop>England</cop><pmid>25025715</pmid><doi>10.1097/MIB.0000000000000128</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Colonoscopy Contrast Media Crohn Disease - pathology Diffusion Magnetic Resonance Imaging - methods Female Follow-Up Studies Humans Ileitis - diagnosis Ileum - pathology Image Processing, Computer-Assisted Inflammation - diagnosis Male Middle Aged Prognosis Retrospective Studies |
| title | Diffusion-weighted magnetic resonance for assessing ileal Crohn's disease activity |
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