G protein-coupled receptor 43 moderates gut inflammation through cytokine regulation from mononuclear cells

Short-chain fatty acids (SCFAs), which are produced by the fermentation of dietary fiber by intestinal microbiota, may positively influence immune responses and protect against gut inflammation. SCFAs bind to G protein-coupled receptor 43 (GPR43). Here, we show that SCFA-GPR43 interactions profoundl...

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Veröffentlicht in:	Inflammatory bowel diseases 2013-12, Vol.19 (13), p.2848-2856
Hauptverfasser:	Masui, Ryuta, Sasaki, Makoto, Funaki, Yasushi, Ogasawara, Naotaka, Mizuno, Mari, Iida, Akihito, Izawa, Shinya, Kondo, Yoshihiro, Ito, Yoshitsugi, Tamura, Yasuhiro, Yanamoto, Kenichiro, Noda, Hisatsugu, Tanabe, Atsushi, Okaniwa, Noriko, Yamaguchi, Yoshiharu, Iwamoto, Takashi, Kasugai, Kunio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytokines - metabolism Dextran Sulfate - toxicity Enterocolitis - chemically induced Enterocolitis - metabolism Enterocolitis - pathology Enzyme-Linked Immunosorbent Assay Fatty Acids, Volatile - metabolism Female Gastrointestinal Tract - metabolism Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Leukocytes - immunology Leukocytes - metabolism Leukocytes - pathology Mice Mice, Inbred C57BL Mice, Knockout Receptors, G-Protein-Coupled - physiology
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