Apoptotic cells ameliorate chronic intestinal inflammation by enhancing regulatory B-cell function

Apoptosis is a programmed physiological death of unwanted cells, and handling of apoptotic cells (ACs) is thought to have profound effects on immune-mediated disorders. However, there is scant information regarding the role of ACs in intestinal inflammation, in which immune homeostasis is a major co...

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Veröffentlicht in:	Inflammatory bowel diseases 2014-12, Vol.20 (12), p.2308-2320
Hauptverfasser:	Ansary, Md Mesbah Uddin, Ishihara, Shunji, Oka, Akihiko, Kusunoki, Ryusaku, Oshima, Naoki, Yuki, Takafumi, Kawashima, Kousaku, Maegawa, Hidetaka, Kashiwagi, Nobuhito, Kinoshita, Yoshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - immunology Arthritis, Experimental - immunology Arthritis, Experimental - metabolism Arthritis, Experimental - pathology B-Lymphocytes, Regulatory - immunology B-Lymphocytes, Regulatory - metabolism B-Lymphocytes, Regulatory - pathology Cells, Cultured Chronic Disease Colitis - immunology Colitis - metabolism Colitis - pathology Enzyme-Linked Immunosorbent Assay Flow Cytometry Immunoenzyme Techniques Inflammation - immunology Inflammation - metabolism Inflammation - pathology Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Mice Mice, Inbred AKR Mice, Inbred C57BL Mice, Knockout Mice, SCID Neutrophils - immunology Neutrophils - metabolism Neutrophils - pathology Rabbits Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics
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