BDNF plasma levels variations in major depressed patients receiving duloxetine
It has been frequently reported that brain-derived neurotrophic factor (BDNF) plays an important role in the pathophysiology of major depressive disorder (MDD). Objective of the study was to investigate BDNF levels variations in MDD patients during antidepressant treatment with duloxetine. 30 MDD pa...
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| Veröffentlicht in: | Neurological sciences 2015-05, Vol.36 (5), p.729-734 |
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| creator | Fornaro, Michele Escelsior, Andrea Rocchi, Giulio Conio, Benedetta Magioncalda, Paola Marozzi, Valentina Presta, Andrea Sterlini, Bruno Contini, Paola Amore, Mario Fornaro, Pantaleo Martino, Matteo |
| description | It has been frequently reported that brain-derived neurotrophic factor (BDNF) plays an important role in the pathophysiology of major depressive disorder (MDD). Objective of the study was to investigate BDNF levels variations in MDD patients during antidepressant treatment with duloxetine. 30 MDD patients and 32 healthy controls were assessed using Hamilton Depression Scale (HAM-D) and monitored for BDNF plasma levels at baseline, week 6 and week 12 of duloxetine treatment (60 mg/day) and at baseline, respectively. According to early clinical response to duloxetine (defined at week 6 by reduction >50 % of baseline HAM-D score), MDD patients were distinguished in early responders (ER) and early non-responders (ENR), who reached clinical response at week 12. Laboratory analysis showed significant lower baseline BDNF levels among patients compared to controls. During duloxetine treatment, in ENR BDNF levels increased, reaching values not significantly different compared to controls, while in ER BDNF levels remained nearly unchanged. Lower baseline BDNF levels observed in patients possibly confirm an impairment of the NEI stress-adaptation system and neuroplasticity in depression, while BDNF increase and normalization observed only in ENR might suggest differential neurobiological backgrounds in ER vs. ENR within the depressive syndrome. |
| doi_str_mv | 10.1007/s10072-014-2027-7 |
| format | Article |
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Objective of the study was to investigate BDNF levels variations in MDD patients during antidepressant treatment with duloxetine. 30 MDD patients and 32 healthy controls were assessed using Hamilton Depression Scale (HAM-D) and monitored for BDNF plasma levels at baseline, week 6 and week 12 of duloxetine treatment (60 mg/day) and at baseline, respectively. According to early clinical response to duloxetine (defined at week 6 by reduction >50 % of baseline HAM-D score), MDD patients were distinguished in early responders (ER) and early non-responders (ENR), who reached clinical response at week 12. Laboratory analysis showed significant lower baseline BDNF levels among patients compared to controls. During duloxetine treatment, in ENR BDNF levels increased, reaching values not significantly different compared to controls, while in ER BDNF levels remained nearly unchanged. Lower baseline BDNF levels observed in patients possibly confirm an impairment of the NEI stress-adaptation system and neuroplasticity in depression, while BDNF increase and normalization observed only in ENR might suggest differential neurobiological backgrounds in ER vs. ENR within the depressive syndrome.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-014-2027-7</identifier><identifier>PMID: 25501804</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Adolescent ; Adult ; Aged ; Antidepressive Agents - therapeutic use ; Brain-Derived Neurotrophic Factor - blood ; Depressive Disorder, Major - blood ; Depressive Disorder, Major - drug therapy ; Duloxetine Hydrochloride - therapeutic use ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Original Article ; Outpatients ; Psychiatric Status Rating Scales ; Psychiatry ; Time Factors ; Young Adult</subject><ispartof>Neurological sciences, 2015-05, Vol.36 (5), p.729-734</ispartof><rights>Springer-Verlag Italia 2014</rights><rights>Springer-Verlag Italia 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-fba22f0085bd41ae9916faa168819421d1c0dbe0cfe2b654256b62ce6a6b278c3</citedby><cites>FETCH-LOGICAL-c475t-fba22f0085bd41ae9916faa168819421d1c0dbe0cfe2b654256b62ce6a6b278c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10072-014-2027-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10072-014-2027-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25501804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fornaro, Michele</creatorcontrib><creatorcontrib>Escelsior, Andrea</creatorcontrib><creatorcontrib>Rocchi, Giulio</creatorcontrib><creatorcontrib>Conio, Benedetta</creatorcontrib><creatorcontrib>Magioncalda, Paola</creatorcontrib><creatorcontrib>Marozzi, Valentina</creatorcontrib><creatorcontrib>Presta, Andrea</creatorcontrib><creatorcontrib>Sterlini, Bruno</creatorcontrib><creatorcontrib>Contini, Paola</creatorcontrib><creatorcontrib>Amore, Mario</creatorcontrib><creatorcontrib>Fornaro, Pantaleo</creatorcontrib><creatorcontrib>Martino, Matteo</creatorcontrib><title>BDNF plasma levels variations in major depressed patients receiving duloxetine</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><addtitle>Neurol Sci</addtitle><description>It has been frequently reported that brain-derived neurotrophic factor (BDNF) plays an important role in the pathophysiology of major depressive disorder (MDD). Objective of the study was to investigate BDNF levels variations in MDD patients during antidepressant treatment with duloxetine. 30 MDD patients and 32 healthy controls were assessed using Hamilton Depression Scale (HAM-D) and monitored for BDNF plasma levels at baseline, week 6 and week 12 of duloxetine treatment (60 mg/day) and at baseline, respectively. According to early clinical response to duloxetine (defined at week 6 by reduction >50 % of baseline HAM-D score), MDD patients were distinguished in early responders (ER) and early non-responders (ENR), who reached clinical response at week 12. Laboratory analysis showed significant lower baseline BDNF levels among patients compared to controls. During duloxetine treatment, in ENR BDNF levels increased, reaching values not significantly different compared to controls, while in ER BDNF levels remained nearly unchanged. Lower baseline BDNF levels observed in patients possibly confirm an impairment of the NEI stress-adaptation system and neuroplasticity in depression, while BDNF increase and normalization observed only in ENR might suggest differential neurobiological backgrounds in ER vs. ENR within the depressive syndrome.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Depressive Disorder, Major - blood</subject><subject>Depressive Disorder, Major - drug therapy</subject><subject>Duloxetine Hydrochloride - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Outpatients</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkctKxDAUhoMoznh5ADcScOOmepJJmnTpbVQQ3eg6pO2pdOjNpB307U3pKCIIbpLA-c53kvyEHDE4YwDq3I8rj4CJiANXkdoicyYTiBZC6e3NmWklZmTP-xVAINlil8y4lMA0iDl5vLx-XNKusr62tMI1Vp6urSttX7aNp2VDa7tqHc2xc-g95rQLJWx6Tx1mWK7L5pXmQ9W-Y182eEB2Clt5PNzs--RlefN8dRc9PN3eX108RJlQso-K1HJeAGiZ5oJZTBIWF9ayWGuWCM5ylkGeImQF8jSWgss4jXmGsY1TrnS22Cenk7dz7duAvjd16TOsKttgO3gTTCAkSCH_gSqlE5BaB_TkF7pqB9eEh4zUeA-WjEI2UZlrvXdYmM6VtXUfhoEZEzFTLib8thlzMSr0HG_MQ1pj_t3xFUQA-AT4UGpe0f0Y_af1E8XFlxY</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Fornaro, Michele</creator><creator>Escelsior, Andrea</creator><creator>Rocchi, Giulio</creator><creator>Conio, Benedetta</creator><creator>Magioncalda, Paola</creator><creator>Marozzi, Valentina</creator><creator>Presta, Andrea</creator><creator>Sterlini, Bruno</creator><creator>Contini, Paola</creator><creator>Amore, Mario</creator><creator>Fornaro, Pantaleo</creator><creator>Martino, Matteo</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150501</creationdate><title>BDNF plasma levels variations in major depressed patients receiving duloxetine</title><author>Fornaro, Michele ; 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Objective of the study was to investigate BDNF levels variations in MDD patients during antidepressant treatment with duloxetine. 30 MDD patients and 32 healthy controls were assessed using Hamilton Depression Scale (HAM-D) and monitored for BDNF plasma levels at baseline, week 6 and week 12 of duloxetine treatment (60 mg/day) and at baseline, respectively. According to early clinical response to duloxetine (defined at week 6 by reduction >50 % of baseline HAM-D score), MDD patients were distinguished in early responders (ER) and early non-responders (ENR), who reached clinical response at week 12. Laboratory analysis showed significant lower baseline BDNF levels among patients compared to controls. During duloxetine treatment, in ENR BDNF levels increased, reaching values not significantly different compared to controls, while in ER BDNF levels remained nearly unchanged. Lower baseline BDNF levels observed in patients possibly confirm an impairment of the NEI stress-adaptation system and neuroplasticity in depression, while BDNF increase and normalization observed only in ENR might suggest differential neurobiological backgrounds in ER vs. ENR within the depressive syndrome.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>25501804</pmid><doi>10.1007/s10072-014-2027-7</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Antidepressive Agents - therapeutic use Brain-Derived Neurotrophic Factor - blood Depressive Disorder, Major - blood Depressive Disorder, Major - drug therapy Duloxetine Hydrochloride - therapeutic use Female Humans Male Medicine Medicine & Public Health Middle Aged Neurology Neuroradiology Neurosciences Neurosurgery Original Article Outpatients Psychiatric Status Rating Scales Psychiatry Time Factors Young Adult |
| title | BDNF plasma levels variations in major depressed patients receiving duloxetine |
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