DNA Methyltransferase Inhibitor Zebularine Induces Human Cholangiocarcinoma Cell Death through Alteration of DNA Methylation Status: e0120545

Cholangiocarcinoma (CCA) is a cancer arising from the neoplastic transformation of cholangiocytes. During tumorigenesis, tumor suppressor and cancer-related genes are commonly silenced by aberrant DNA methylation in their promoter regions. Zebularine (1-( beta -D-ribofuranosyl)-1,2-dihydropyrimidin-...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3)
Hauptverfasser:	Nakamura, Kazuaki, Nakabayashi, Kazuhiko, Aung, Kyaw Htet, Aizawa, Kazuko, Hori, Naoko, Yamauchi, Junji, Hata, Kenichiro, Tanoue, Akito
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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