N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotides

Protected N-branched nucleoside phosphonates containing adenine and thymine bases were prepared as the monomers for the introduction of aza-acyclic nucleotide units into modified oligonucleotides. The phosphotriester and phosphoramidite methods were used for the incorporation of modified and natural...

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Veröffentlicht in:Organic & biomolecular chemistry 2015-04, Vol.13 (15), p.4449-4458
Hauptverfasser: Hocková, Dana, Rosenbergová, Šárka, Ménová, Petra, Páv, Ondřej, Pohl, Radek, Novák, Pavel, Rosenberg, Ivan
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Sprache:eng
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